Nuclear clusterin accumulation during heat shock response: Implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells

2006 ◽  
Vol 207 (1) ◽  
pp. 208-219 ◽  
Author(s):  
Alessandro E. Caccamo ◽  
Silvia Desenzani ◽  
Lucia Belloni ◽  
Angelo F. Borghetti ◽  
Saverio Bettuzzi
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Cell Survival ◽  
Cancer Cells ◽  
Heat Shock Response ◽  
Tolerance Induction ◽  
Prostate Cancer Cells ◽  
Shock Response

Cytochrome P450 17A1 Inhibitor Abiraterone Acetate Counteracts the Heat Shock Protein 27's Cell Survival Properties in Prostate Cancer Cells

2016 ◽  
Vol 97 (1) ◽  
pp. 112-117 ◽  
Author(s):  
Martin Weiss ◽  
Hannes Ahrend ◽  
Hannah Grossebrummel ◽  
Patrick Ziegler ◽  
Lars-Ove Brandenburg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cytochrome P450 ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Survival ◽  
Cancer Cells ◽  
Heat Shock Protein 27 ◽  
Abiraterone Acetate ◽  
Prostate Cancer Cells

scholarly journals Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

2009 ◽  
Vol 124 (7) ◽  
pp. 1675-1684 ◽  
Author(s):  
Vinita Singh-Gupta ◽  
Hao Zhang ◽  
Sanjeev Banerjee ◽  
Dejuan Kong ◽  
Julian J. Raffoul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Soy Isoflavones ◽  
Prostate Cancer Cells ◽  
Survival Pathway ◽  
Radiation Induced

scholarly journals Cisplatin and Paclitaxel Modulated the Cell Survival Potential of Prostate Cancer Cells

Proceedings ◽  
2020 ◽  
Vol 40 (1) ◽  
pp. 42
Author(s):  
Kashani ◽  
Kilbas ◽  
Yerlikaya ◽  
Gurkan ◽  
Arisan
Keyword(s):  
Prostate Cancer ◽  
Cell Viability ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Dependent Manner ◽  
Prostate Cancer Cells ◽  
Cell Viability Assay ◽  
Chemotherapy Drugs

Prostate cancer is the second common cause of death among men worldwide. In the treatment of prostate cancer, conventional chemotherapeutics are commonly used. The plant alkaloid Paclitaxel and platinum-based cisplatin are the most common chemotherapy drugs. The transcription factor p53 has a potential target in the regulation of cell response to DNA damage of prostate cancer. Although the effectiveness of these drugs on prostate cancer cell progression had been proved, the mechanistic action of these drugs on the progression of the disease is not detailed explained. In this study, we aim to examine the function of p53 overexpression in prostate cancer cell survival. Therefore, we treated wild type (wt) and p53 overexpressed PC3 (p53+) prostate cancer cells with cisplatin or paclitaxel. According to the MTT Cell Viability assay, cisplatin (12.5–25–50 µM) was found to be more effective decreasing PC3 and PC3 p53+ cell viability in a dose-dependent manner compared to paclitaxel (12.5–25–50 nM). Colony formation assay showed that treatment of cells with cisplatin or paclitaxel caused the loss of colony forming ability of PC3 and PC3 p53+ cells. In addition, the critical apoptotic markers Caspase-3 and Caspase-9 expressions were altered with cisplatin or paclitaxel treated PC3 wt and p53+ cells.

scholarly journals Heat shock protein 70 inhibitors suppress androgen receptor expression in LNC aP95 prostate cancer cells

2017 ◽  
Vol 108 (9) ◽  
pp. 1820-1827 ◽  
Author(s):  
Kazuaki Kita ◽  
Masayuki Shiota ◽  
Masako Tanaka ◽  
Asuka Otsuka ◽  
Masaki Matsumoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Heat Shock Protein 70 ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Prostate Cancer Cells

scholarly journals KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90α in Prostate Cancer Cells

2015 ◽  
Vol 88 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Weiya Liu ◽  
George A. Vielhauer ◽  
Jeffrey M. Holzbeierlein ◽  
Huiping Zhao ◽  
Suman Ghosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Protein Inhibitor ◽  
Prostate Cancer Cells ◽  
Isoform Selectivity
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