scholarly journals Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

2009 ◽  
Vol 124 (7) ◽  
pp. 1675-1684 ◽  
Author(s):  
Vinita Singh-Gupta ◽  
Hao Zhang ◽  
Sanjeev Banerjee ◽  
Dejuan Kong ◽  
Julian J. Raffoul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Soy Isoflavones ◽  
Prostate Cancer Cells ◽  
Survival Pathway ◽  
Radiation Induced

Membrane Fluidity, Invasiveness and Dynamic Phenotype of Metastatic Prostate Cancer Cells after Treatment with Soy Isoflavones

2013 ◽  
Vol 246 (4) ◽  
pp. 307-314 ◽  
Author(s):  
Vladimir Ajdžanović ◽  
Marija Mojić ◽  
Danijela Maksimović-Ivanić ◽  
Mirna Bulatović ◽  
Sanja Mijatović ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Membrane Fluidity ◽  
Metastatic Prostate Cancer ◽  
Soy Isoflavones ◽  
Prostate Cancer Cells

scholarly journals Cisplatin and Paclitaxel Modulated the Cell Survival Potential of Prostate Cancer Cells

Proceedings ◽  
2020 ◽  
Vol 40 (1) ◽  
pp. 42
Author(s):  
Kashani ◽  
Kilbas ◽  
Yerlikaya ◽  
Gurkan ◽  
Arisan
Keyword(s):  
Prostate Cancer ◽  
Cell Viability ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Dependent Manner ◽  
Prostate Cancer Cells ◽  
Cell Viability Assay ◽  
Chemotherapy Drugs

Prostate cancer is the second common cause of death among men worldwide. In the treatment of prostate cancer, conventional chemotherapeutics are commonly used. The plant alkaloid Paclitaxel and platinum-based cisplatin are the most common chemotherapy drugs. The transcription factor p53 has a potential target in the regulation of cell response to DNA damage of prostate cancer. Although the effectiveness of these drugs on prostate cancer cell progression had been proved, the mechanistic action of these drugs on the progression of the disease is not detailed explained. In this study, we aim to examine the function of p53 overexpression in prostate cancer cell survival. Therefore, we treated wild type (wt) and p53 overexpressed PC3 (p53+) prostate cancer cells with cisplatin or paclitaxel. According to the MTT Cell Viability assay, cisplatin (12.5–25–50 µM) was found to be more effective decreasing PC3 and PC3 p53+ cell viability in a dose-dependent manner compared to paclitaxel (12.5–25–50 nM). Colony formation assay showed that treatment of cells with cisplatin or paclitaxel caused the loss of colony forming ability of PC3 and PC3 p53+ cells. In addition, the critical apoptotic markers Caspase-3 and Caspase-9 expressions were altered with cisplatin or paclitaxel treated PC3 wt and p53+ cells.

scholarly journals Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells

2010 ◽  
Vol 235 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Anna Hsu ◽  
Tammy M Bray ◽  
William G Helferich ◽  
Daniel R Doerge ◽  
Emily Ho
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Soy Isoflavones ◽  
Prostate Cancer Cells ◽  
Differential Effects
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