Childhood trauma, parental bonding, and social cognition in patients with schizophrenia and healthy adults

2020 ◽  
Vol 77 (1) ◽  
pp. 241-253 ◽  
Author(s):  
Karolina I. Rokita ◽  
Maria R. Dauvermann ◽  
David Mothersill ◽  
Laurena Holleran ◽  
Jessica Holland ◽  
...  
Keyword(s):  
Social Cognition ◽  
Childhood Trauma ◽  
Parental Bonding ◽  
Healthy Adults

scholarly journals S80. CHILDHOOD TRAUMA AND SOCIAL COGNITION IN DELUSIONAL PSYCHOSES

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S64-S65
Author(s):  
Covadonga Díaz-Caneja ◽  
Marcos González-Iglesias ◽  
Victoria Del Amo ◽  
Ignacio García-Cabeza ◽  
Celso Arango ◽  
...  
Keyword(s):  
Working Memory ◽  
Executive Function ◽  
Social Cognition ◽  
Childhood Trauma ◽  
Neuropsychological Functioning ◽  
Attributional Bias ◽  
Cohen’S D ◽  
Dsm Iv ◽  
The Difference ◽  
Cohen's D

Abstract Background Deficits in social cognition could be involved in the pathogenesis of delusions in psychotic disorders (Bentall et al., 2009). Childhood trauma (CT) has been associated with an increased risk for psychosis (Varese et al., 2012). Neurocognitive and social cognition deficits could mediate in the association between CT and psychosis (Mansueto et al., 2019). Social cognition and childhood trauma have been understudied so far in delusional disorder (DD). We aimed to assess social cognition in a sample of patients with delusional psychoses (i.e., DD and schizophrenia) and healthy controls (HC) and to explore the potential effect of childhood trauma on social cognition and delusion. Methods This cross-sectional, transdiagnostic study included 69 patients with a DSM-IV-TR-confirmed diagnosis of DD (mean age 44.06 ± 11.39 years, 53.6% female), 77 with DSM-IV-TR-confirmed schizophrenia (mean age 38.12 ± 9.27 years, 27.3% female), and 63 HC (mean age 43.6 ± 13.0 years, 68.3% female). Attributional bias was assessed with the “Internal, Personal, and Situational Attributions Questionnaire.” Theory of Mind (ToM) performance was assessed with the “Reading the Mind in the Eyes Test” and the “Faux Pas Recognition Test.” Childhood trauma was measured with the “Childhood Trauma Questionnaire.” Neuropsychological functioning was measured with a comprehensive battery assessing attention, verbal learning, working memory, and executive function. We used ANCOVAs and linear regression analyses to assess the association between the three measures of social cognition and i) diagnosis, ii) dimensional measures of delusion proneness (Peters Delusion Inventory, PDI) and intensity (Maudsley Assessment of Delusion Schedule, MADS), and iii) childhood trauma; after controlling for potential confounders (age, sex, socioeconomic status, and estimated premorbid intelligence quotient). Results Patients with DD showed significantly poorer performance on the “Eyes Test” than HC (Cohen’s d=-0.44, p=0.037), after controlling for potential confounding variables. The difference was no longer significant after controlling for verbal memory. Patients with schizophrenia (d=-1.54, p<0.001) and DD (Cohen’s d=-0.60, p=0.002) showed significantly poorer performance than HC on the “Faux Pas Test,” after controlling for potential confounders. The difference between patients with schizophrenia and HC remained significant after controlling for neuropsychological functioning (Cohen’s d=-1.09, p<0.001), while differences between patients with DD and HC were no longer significant after controlling for executive function and working memory performance (Cohen’s d=-0.23, p=0.596). No significant differences were found between diagnostic groups in externalizing or personalizing attributional bias. In the fully adjusted models, intensity of the delusional idea was significantly associated with performance in the “Faux Pas Test” in DD, and with externalizing and personalizing attributional bias in schizophrenia. A positive history of CT was significantly associated with lower performance on the “Faux Pas Test” (Cohen’s d=-0.40, p=.022) and higher delusional proneness scores in the delusional psychosis samples (Cohen’s d=-0.49, p=.006), but not in HC. Discussion Social cognition deficits are associated with delusional intensity in delusional psychoses. Childhood trauma could increase the risk of psychosis through its effect on social cognition.

scholarly journals Neural correlates of childhood trauma with executive function in young healthy adults

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 79843-79853 ◽  
Author(s):  
Shaojia Lu ◽  
Fen Pan ◽  
Weijia Gao ◽  
Zhaoguo Wei ◽  
Dandan Wang ◽  
...  
Keyword(s):  
Executive Function ◽  
Childhood Trauma ◽  
Neural Correlates ◽  
Healthy Adults

scholarly journals Gender differences in the associations between childhood trauma and parental bonding in panic disorder

2009 ◽  
Vol 31 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Ana Carolina Gaspar Seganfredo ◽  
Mariana Torres ◽  
Giovanni Abrahão Salum ◽  
Carolina Blaya ◽  
Jandira Acosta ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Childhood Trauma ◽  
Emotional Abuse ◽  
Parental Bonding ◽  
The Other ◽  
Childhood Trauma Questionnaire ◽  
Parental Bonding Instrument ◽  
Different Types ◽  
Highly Correlated

OBJECTIVE: The aim of this study is to evaluate the association between childhood trauma and the quality of parental bonding in panic disorder compared to non-clinical controls. METHOD: 123 patients and 123 paired controls were evaluated with the Mini International Neuropsychiatric Interview, the Childhood Trauma Questionnaire and the Parental Bonding Instrument. RESULTS: The Parental Bonding Instrument and the Childhood Trauma Questionnaire were highly correlated. Panic disorder patients presented higher rates of emotional abuse (OR = 2.54, p = 0.001), mother overprotection (OR = 1.98, p = 0.024) and father overprotection (OR = 1.84, p = 0.041) as compared to controls. Among men with panic disorder, only mother overprotection remained independently associated with panic disorder (OR = 3.28, p = 0.032). On the other hand, higher father overprotection (OR = 2.2, p = 0.017) and less father warmth (OR = 0.48, p = 0.039) were independently associated with panic disorder among female patients. CONCLUSION: Higher rates of different types of trauma, especially emotional abuse, are described in panic disorder patients as compared to controls. The differences regarding gender and parental bonding could be explained in the light of the psychodynamic theory.

scholarly journals Evidence for an Interaction Between NEDD4 and Childhood Trauma on Clinical Characters of Schizophrenia With Family History of Psychosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiao-Jiao Bi ◽  
Lei Hu ◽  
Dong-Dong Qiao ◽  
Chao Han ◽  
Meng-Meng Sun ◽  
...  
Keyword(s):  
Working Memory ◽  
Social Cognition ◽  
Family History ◽  
Learning And Memory ◽  
Childhood Trauma ◽  
Visual Learning ◽  
Environment Interaction ◽  
Memory Score ◽  
History Of ◽  
Physical Neglect

Background: Neural precursor cell-expressed developmentally downregulated 4 (NEDD4) polymorphisms and childhood trauma (CT) are associated with schizophrenia. However, whether NEDD4 interacts with CT on symptoms of schizophrenia remains unknown. This study aimed to investigate the gene–environment interaction effect.Methods: We recruited 289 schizophrenia patients and 487 controls and genotyped rs2303579, rs3088077, rs7162435, rs11550869, and rs62043855 in their NEDD4 gene.Results: We found significant differences in the rs2303579 and rs3088077 between the two groups. Patients with the rs2303579 CC genotype had higher scores compared with other genotype (P = 0.026) in the test of positive schizophrenia syndrome scores, whereas patients with the rs3088077 TT (P = 0.037) and rs7162435 CC genotypes (P = 0.009) had higher scores compared with the other genotypes in the test of excitement factor. Patients with a family history of psychosis (FH+) reported higher negative scores (P = 0.012) than those without. Patients exposed to physical abuse (PA) reported a lower language learning and memory score (P = 0.017) and working memory score (P = 0.047) than those not. Patients exposed to sexual abuse (SA) reported a lower reasoning and problem-solving skills score (P = 0.025); those exposed to emotional neglect (EN) reported a lower social cognition score (P = 0.044); and those exposed to physical neglect reported a lower social cognition score (P = 0.036) but higher visual learning and memory score (P = 0.032). Rs3088077 could interact with EN to increase risk for schizophrenia. Optimal model rs62043855 × EA, rs3088077 × rs7162435 × rs11550869 × SA × EN and rs2303579 × rs7162435 × rs11550869 × rs62043855 × EA × PA could explain positive symptom, excitement symptom and working memory, respectively, in FH+ group.Conclusion: The study highlighted that the combined interaction of NEDD4 and CT may be associated with symptoms of schizophrenia especially for those with FH+.

Association between different types of childhood trauma and parental bonding with antisocial traits in adulthood: A systematic review

2020 ◽  
Vol 107 ◽  
pp. 104621
Author(s):  
Manuela Teixeira Schorr ◽  
Bárbara Tietbohl-Santos ◽  
Lucas Mendes de Oliveira ◽  
Luciana Terra ◽  
Lisieux Elaine de Borba Telles ◽  
...  
Keyword(s):  
Systematic Review ◽  
Childhood Trauma ◽  
Parental Bonding ◽  
Different Types

scholarly journals F76. CHILDHOOD TRAUMA RELATED TO ABNORMAL SOCIAL COGNITION IN SCHIZOPHRENIA

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S249-S249
Author(s):  
Aldara Alvarez Astorga ◽  
Alba Lubeiro Juárez ◽  
Eva Sotelo ◽  
Mercedes Vaquero ◽  
Vicente Molina Rodriguez
Keyword(s):  
Social Cognition ◽  
Childhood Trauma

scholarly journals Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task

2015 ◽  
Vol 10 (1) ◽  
pp. 124-135 ◽  
Author(s):  
Noah S. Philip ◽  
Lawrence H. Sweet ◽  
Audrey R. Tyrka ◽  
S. Louisa Carpenter ◽  
Sarah E. Albright ◽  
...  
Keyword(s):  
Working Memory ◽  
Childhood Trauma ◽  
Memory Task ◽  
Healthy Adults ◽  
And Performance
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