scholarly journals The impact of an URAT1 polymorphism on the losartan treatment of hypertension and hyperuricemia

2021 ◽  
Author(s):  
Liting Wu ◽  
Yingchao Fan ◽  
Yuan Wang ◽  
Zhumeng Li ◽  
Delong Mao ◽  
...  
Keyword(s):  
Treatment Of Hypertension ◽  
The Impact ◽  
Losartan Treatment

New drugs for hypertension – variations on old themes

1991 ◽  
Vol 29 (6) ◽  
pp. 21-22
Keyword(s):  
Calcium Antagonists ◽  
Plasma Lipids ◽  
Arterial Disease ◽  
New Drugs ◽  
Converting Enzyme ◽  
First Line ◽  
Treatment Of Hypertension ◽  
Adrenergic Blockers ◽  
The Impact

Alpha-adrenergic blockers, calcium antagonists and some angiotensin-converting enzyme (ACE) inhibitors are now promoted as first-line drugs for the treatment of hypertension, competing with the traditional choices of β-adrenergic blockers and diuretics. The older drugs have established long-term benefits, but have some theoretical disadvantages and sometimes unwanted effects. No trials have looked at the impact of these new drugs on cardiovascular disease; studies of their efficacy have examined only immediate outcome measures such as blood pressure, and their effects on other risk factors for arterial disease such as plasma lipids. Choosing a drug for the initial treatment of hypertension has therefore become more difficult. We discuss here a new α-blocker and three recently marketed calcium antagonists.

scholarly journals Burning issues in the prevention of heart failure

2019 ◽  
Vol 61 (4) ◽  
pp. 11-12
Author(s):  
J. A. Ker ◽  
K. Outhoff
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Lifestyle Interventions ◽  
Clinical Question ◽  
Type Ii ◽  
Treatment Of Hypertension ◽  
Lack Of Exercise ◽  
The Impact

Chronic heart failure is common, debilitating, and often the culmination of pervasive cardiovascular insults that systematically undermine the heart’s circulatory capacity and invoke counterproductive neuro-hormonal compensatory changes. Prevention of chronic heart failure therefore requires minimising the impact of traditional cardiovascular risk factors with incisive treatment of hypertension and type II Diabetes Mellitus (T2DM) and prompt lifestyle interventions for smoking, lack of exercise, obesity and hypercholesterolemia. This review is narrative, with selected emphasis on major studies, rather than structured on a specific clinical question, and should be read as such.

scholarly journals Adherence to non-pharmacological treatment: Analysis of the impact of three health educational and nutritional strategies in hypertensive patients

2016 ◽  
Vol 29 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Juliana Costa MACHADO ◽  
Rosângela Minardi Mitre COTTA ◽  
Tiago Ricardo MOREIRA ◽  
Luciana Saraiva da SILVA
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Pharmacological Treatment ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Treatment Of Hypertension ◽  
The Impact ◽  
Nutritional Strategies

ABSTRACT Objective: To evaluate adherence to non-pharmacological treatment of hypertension by comparing biochemical, clinical, anthropometric, and dietary parameters before and after three health educational and nutritional strategies. Methods: This longitudinal clinical trial included 212 hypertensive individuals who met the inclusion criteria. The participants were allocated to three groups to assess the impact of monthly intervention methods over twelve months. Results: Waist circumference decreased significantly in all groups. Weight and body mass index decreased significantly in Groups 2 and 3. Blood glucose, total cholesterol, and low-density lipoprotein cholesterol decreased significantly in Groups 1 and 2. The interventions also reduced the mean per capita intakes of oil, sugar, and salt in all groups. Conclusion: Educational interventions promoted adherence to non-pharmacological treatment of treatment of hypertension evidenced by anthropometric (weight, body mass index, and waist circumference), biochemical (blood glucose, total cholesterol, and low-density lipoprotein cholesterol), and dietary (meanper capita intake of oil, sugar, and salt) parameters.

Effectiveness of Valsartan for Treatment of Hypertension: Patient Profiling and Hierarchical Modeling of Determinants and Outcomes (the Preview Study)

2009 ◽  
Vol 43 (5) ◽  
pp. 849-861 ◽  
Author(s):  
Patricia Van Der Niepen ◽  
Annemie Woestenburg ◽  
Heidi Brié ◽  
Stefaan Vancayzeele ◽  
Karen Macdonald ◽  
...  
Keyword(s):  
Hierarchical Modeling ◽  
Antihypertensive Agents ◽  
Diabetic Patients ◽  
Related Factors ◽  
Hypertensive Patients ◽  
Therapeutic Benefits ◽  
Treatment Of Hypertension ◽  
Patient Profiling ◽  
Pharmacologic Effect ◽  
The Impact

Background Patient- and clinician-related factors may explain variability in blood pressure (BP) outcomes and the differences between real-world effectiveness and efficacy seen in randomized trials of antihypertensive agents. Objective To examine the effectiveness of 90 days of second-line valsartan treatment and identify patient- and physician-level determinants that impact BP outcomes. Methods A prospective, multicenter, multilevel pharmacoepidemiologic study was conducted in 3194 hypertensive patients (systolic BP [SBP] ≥140 mm Hg, diastolic BP [DBP] ≥90 mm Hg; for diabetic patients, ≥130 and ≥80 mm Hg, respectively) treated by 504 general practitioners (GPs). Statistical analysis included heuristic data mining, and hierarchical linear and logistic modeling. Results With valsartan treatment, mean ± SD SBP decreased from 154.4 ± 15.5 mm Hg to 139.0 ± 12.0 mm Hg and mean DBP decreased from 91.3 ± 9.2 mm Hg to 82.6 ± 7.4 mm Hg. SBP control rates increased from 9.0% to 38.6%, DBP from 25.5% to 65.5%, and combined SBP/DBP from 7.3% to 34.4%. A highly vulnerable cohort (n = 1063;35.4%) of patients was identified. Twenty-four percent of variability in SBP and 25% of variability in DBP at 90 days were attributable to physician-related variables: guideline-compliant BP management, hypertension, practice patterns, hypertensive patient volume, and years in practice. The remaining 76% and 75% of variability in SBP and DBP, respectively, were due to patient factors, notably diabetes and related complications, vulnerability to uncontrolled BP, nonadherence, cardiovascular risk, and age. Simitar factors increased the odds of treatment nonresponse, with diabetes being the single largest determinant of uncontrolled SBP (OR 8.99), DBP (OR 20.35), and combined SBP/DBP (OR = 18.64). Conclusions Valsartan is effective and well tolerated in a broad range of patients in whom first-line antihypertensive treatment failed or was not tolerated. Mitigating the impact of BP-elevating variables and optimizing the effect of BP-lowering factors provides therapeutic benefits incremental to valsartan's pharmacologic effect. Improving outcomes in hypertensive patients involves 3 steps: (1) identifying, intuitively rather than formally, patients less likely to achieve BP control; (2) targeting modifiable or manageable patient- and physician-level determinants with BP-elevating or BP-lowering effects; and (3) managing variables that increase the odds and optimizing those that lower the odds of uncontrolled BP.

scholarly journals Losartan Mitigates Oxidative Stress in the Brains of Aged IL10-/- Mice

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 684-684
Author(s):  
Nazaneen Saleh ◽  
Caglar Cosarderelioglu ◽  
Peter M Abadir ◽  
Ramya Vajapey ◽  
Jeremy D Walston
Keyword(s):  
Oxidative Stress ◽  
Chronic Inflammation ◽  
Renin Angiotensin System ◽  
Tau Proteins ◽  
Oxidative Stress Marker ◽  
Contributory Factor ◽  
Angiotensin System ◽  
Hippocampal Tissue ◽  
The Impact ◽  
Losartan Treatment

Abstract Chronic inflammation has been linked to frailty and declined cognition in older adults. Activation of the renin-angiotensin system (RAS) through the angiotensin Type1 receptor (AT1R) has been suggested as a contributory factor that links both inflammation and aging. Here we examined the impact of 4 weeks of oral Losartan treatment on IL10-/- mice brains, a mouse model of chronic inflammation and frailty. Frontal cortex, cerebellar, and hippocampal tissue of aged (100 weeks old) male IL10-/- mice were studied. Western blot techniques were employed to quantify changes in brain AT1R, nitrotyrosine (NT) as an oxidative stress marker, and Tau proteins. Our data show that aged IL-10 mice have significantly higher levels of AT1R in the cortex tissue but not in cerebellar or hippocampal tissue compared to age and sex-matched WT mice (0.63 + 0.35 vs 1.5 + 0.54, WT vs IL10, respectively, P<0.004). When treated with LOS, brain cortical tissue of IL10 -/- mice showed significant decreases in levels of AT1R (1.5 + 0.54 vs 0.98 + 0.50, IL10 vs LOS treated IL10, respectively, P<0.04), NT (0.72 + 0.12 vs 0.42 + 0.10, IL10 vs LOS treated IL10, respectively, P<0.009), and Tau protein (1.3 + 0.31 vs 0.15 + 0.08, IL10 vs LOS treated IL10, respectively, P<0.004) as compared to control IL10-/- mice. Losartan treatment had no significant effect on hippocampal AT1R or NT levels. Our results highlight the impact of Losartan, a drug commonly prescribed for the treatment of high blood pressure, on the brain-specific angiotensin system and its downstream effects on brain oxidative stress and Tau pathology.

scholarly journals Pendidikan Kesehatan tentang Hipertensi dan Perawatannya pada Anggota PKK RT 01 RW 06 Pedurungan Tengah Semarang

2021 ◽  
Vol 2 (2) ◽  
pp. 170-175
Author(s):  
Maria Agustina Ermi Tri Sulistiyowati ◽  
Raimonda Amayu Ida Vitani ◽  
Dian Puspitasari ◽  
Florentina Niken Widyastuti
Keyword(s):  
Blood Pressure ◽  
Health Education ◽  
Cause Of Death ◽  
Healthy Lifestyle ◽  
Heart Attacks ◽  
Prevention And Treatment ◽  
Treatment Of Hypertension ◽  
Education Activity ◽  
Asking Questions ◽  
The Impact

Abstrak: Hipertensi merupakan suatu penyakit yang banyak dijumpai dan sangat sering menyebabkan serangan jantung yang mematikan. Penyakit ini menempati urutan pertama penyebab kematian di seluruh dunia, termasuk di Indonesia. Hipertensi merupakan silent killer sehingga pengobatannya sering terlambat. Hipertensi  dan komplikasinya dapat dicegah dengan menerapkan pola hidup sehat.  Pendidikan kesehatan dilaksanakan kepada anggota PKK RT 01 RW 06 Pedurungan Tengah dengan memberikan materi tentang hipertensi dan perawatannya. Setelah pemberian materi dan diskusi, dilanjutkan dengan pemeriksaan tekanan darah. Peserta antusias mengikuti penyuluhan dari awal sampai akhir. Dari hasil evaluasi dengan memberikan pertanyaan terkait materi yang diberikan, mereka dapat menyebutkan kembali pengertian, penyebab, tanda gejala, pencegahan serta perawatan hipertensi dengan benar. Dampak dari kegiatan pendidikan kesehatan ini adalah meningkatnya pengetahuan anggota PKK RT 01 RW 06 Pedurungan Tengah tentang hipertensi dan  perawatannya.Abstract: Hypertension is a disease that is common and very often causes deadly heart attacks. This disease ranks as the first cause of death worldwide, including in Indonesia. Hypertension is a silent killer, so treatment is often late. Hypertension and its complications can be prevented by adopting a healthy lifestyle. Health education is carried out to members of the PKK RT 01 RW 06 Pedurungan Tengah by providing material about hypertension and its treatment. After providing material and discussion, it was followed by blood pressure checks. Participants were enthusiastic about attending the counseling from beginning to end. From the results of the evaluation by asking questions related to the material given, they can recite the meaning, causes, symptoms, prevention and treatment of hypertension correctly. The impact of this health education activity is to increase the knowledge of PKK RT 01 RW 06 Pedurungan Tengah members about hypertension and its treatment.

Considering Circadian Pattern of Blood Pressure in the Treatment of Hypertension via Chronotherapy: A Conducive or Maladroit Approach

2019 ◽  
Vol 20 (12) ◽  
pp. 1244-1254
Author(s):  
Rina Das ◽  
Dinesh Kumar Mehta
Keyword(s):  
Blood Pressure ◽  
Hormone Secretion ◽  
Circadian Pattern ◽  
Disease States ◽  
Therapeutic Outcomes ◽  
Treatment Of Hypertension ◽  
Health And Disease ◽  
Night And Day ◽  
Underlying Mechanisms ◽  
The Impact

Medical chronobiology deals with the way body’s rhythm influences a person’s health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeostasis has been the base for the treatment of diseases. Little importance has been given in understanding biologic rhythms and their underlying mechanisms. Designing of cardiovascular drug is done to achieve a constant or near-constant effect throughout the 24-hour with the prescribed dose. However in many cases, medication requirement during night and day time are not the same. Body rhythms may have profound effect on the treatment outcomes. It is a wrongful approach to assume that a drug dosed in the morning or evening will have the same antihypertensive effect. The vast literature record of circadian variations in Blood Pressure (BP), heart rate, hormone secretion, and platelet aggregation are examples of the impact of chronobiology. In this study we analyze the effect of circadian pattern of blood pressure on action of various antihypertensives and investigate the perspective of chronotherapeutics- whether it is a fruitful approach and rationalize its utility in the treatment of hypertension.

scholarly journals The Impact of Medicare Part D on Medication Treatment of Hypertension

2010 ◽  
Vol 46 (1p1) ◽  
pp. 185-198 ◽  
Author(s):  
Yuting Zhang ◽  
Julie M. Donohue ◽  
Judith R. Lave ◽  
Walid F. Gellad
Keyword(s):  
Medicare Part D ◽  
Medicare Part ◽  
Part D ◽  
Medication Treatment ◽  
Treatment Of Hypertension ◽  
The Impact
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