scholarly journals Correlation analysis of long non‐coding RNA TUG1 with disease risk, clinical characteristics, treatment response, and survival profiles of adult Ph − Acute lymphoblastic leukemia

2021 ◽  
Author(s):  
Pengyun Zeng ◽  
Ye Chai ◽  
Chongge You ◽  
Lingling Yue ◽  
Chongyang Wu ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Correlation Analysis ◽  
Treatment Response ◽  
Clinical Characteristics ◽  
Disease Risk ◽  
Lymphoblastic Leukemia ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Oncotarget ◽  
2016 ◽  
Vol 7 (45) ◽  
pp. 73769-73780 ◽  
Author(s):  
Farzaneh Ghazavi ◽  
Barbara De Moerloose ◽  
Wouter Van Loocke ◽  
Annelynn Wallaert ◽  
Hetty H. Helsmoortel ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Rna Expression ◽  
Cell Precursor ◽  
Expression Signature ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Haematologica ◽  
2014 ◽  
Vol 99 (12) ◽  
pp. 1808-1816 ◽  
Author(s):  
K. Durinck ◽  
A. Wallaert ◽  
I. Van de Walle ◽  
W. Van Loocke ◽  
P.-J. Volders ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Non Coding Rna ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Long Non Coding Rna

scholarly journals MAGI2-AS3 Modulates Proliferation, Apoptosis and Glycolysis in Acute Lymphoblastic Leukemia via miR-452-5p/FOXN3 Axis

2021 ◽  
Author(s):  
Xiao-Guang Chen ◽  
Bing-Hua Dou ◽  
Jin-Dou An ◽  
Song Feng ◽  
Na Liu ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Lactate Production ◽  
Xenograft Model ◽  
Luciferase Reporter ◽  
Protein Levels ◽  
Non Coding Rna ◽  
Underlying Mechanisms ◽  
Long Non Coding Rna

Abstract Background: Long non-coding RNA MAGI2 antisense RNA 3 (MAGI2-AS3) has been identified as a tumor suppressor in various cancers. Acute lymphoblastic leukemia (ALL) is a prevalent kind of leukemia among children. In this study, we aimed at evaluate the role of MAGI2-AS3 in ALL and its underlying mechanisms.Methods: qPCR was adopted to determine MAGI2-AS3, miR-452-5p, and FOXN3 expression. The malignant properties of ALL cells were assessed by CCK8 assay and flow cytometry analysis. The glucose uptake, lactate production, and ATP level were measured to evaluate glycolysis. Western blotting was performed to detect PCNA, Bcl-2, Bax, and HK2 protein levels. The interaction between MAGI2-AS3/FOXN3 and miR-452-5p was validated by luciferase reporter assay. The in vivo growth of ALL cells was determined in xenograft model.Results: MAGI2-AS3 was strikingly down-regulated in ALL samples and cells. Overexpression of MAGI2-AS3 restrained growth, glycolysis and triggered apoptosis of ALL cells. Mechanistically, MAGI2-AS3 could sponge miR-452-5p to up-regulate FOXN3. Silencing of FOXN3 abolished the anti-tumor effect of MAGI2-AS3. Finally, MAGI2-AS3 suppressed the in vivo growth of ALL cells via modulating miR-452-5p/FOXN3 axis. Conclusions: Our findings demonstrate that MAGI2-AS3 delays the progression of ALL by regulating miR-452-5p/FOXN3 signaling pathway.

scholarly journals Prognostic significance of protein-coding and long non-coding RNA expression profile in T-cell acute lymphoblastic leukemia

2021 ◽  
Author(s):  
Deepak Verma ◽  
Shruti Kapoor ◽  
Disha Sharma ◽  
Jay Singh ◽  
Gunjan Sharma ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Expression Profile ◽  
Lymphoblastic Leukemia ◽  
High Expression ◽  
Protein Coding ◽  
Non Coding Rna ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Long Non Coding Rna

T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy associated with poor outcome. To unravel gene-expression profile of immunophenotypic subtypes of T-ALL, we did transcriptome analysis in 35 cases. We also analyzed the prognostic relevance of 23 targets: protein-coding genes, histone modifiers and long non-coding RNA (lncRNA) expression profile, identified on RNA sequencing, on an independent cohort of 99 T-ALL cases. We found high expression of MEF2C to be associated with prednisolone resistance (p=0.048) and CD34 expression (p=0.012). BAALC expression was associated with expression of CD34 (p=0.032) and myeloid markers (p=0.021). XIST and KDM6a expression levels were higher in females (p=0.047 and 0.011, respectively). Post-induction minimal residual disease (MRD) positivity was associated with high lncRNA PCAT18 (p=0.04), HHEX (p=0.027) and MEF2C (p=0.007). Early thymic precursor (ETP-ALL) immunophenotype was associated with high expression of MEF2C (p=0.003), BAALC (p=0.003), LYL1 (p=0.01), LYN (p=0.01), XIST (p=0.02) and low levels of ST20 (p=0.007) and EML4 (p=0.03). On survival analysis, MEF2C high expression emerged as significant predictor of 3-year event free survival (EFS) (low 71.78+6.58% vs high 36.57+10.74%, HR 3.5, p=0.0003) and overall survival (OS) (low 94.77+2.96% vs high 78.75+8.45%, HR 4.88, p=0.016) in our patients. LncRNA MALAT1 low expression also emerged as predictor inferior OS (low 76.02+10.48 vs high 94.11+3.31, HR 0.22, p=0.027). Keywords: RNA-Sequencing, T-cell acute lymphoblastic Leukemia, Early thymic precursor, LncRNA, Gene expression profile.

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