scholarly journals Long non‑coding RNA AWPPH interacts with ROCK2 and regulates the proliferation and apoptosis of cancer cells in pediatric T‑cell acute lymphoblastic leukemia

2020 ◽  
Vol 20 (5) ◽  
pp. 1-1 ◽  
Author(s):  
Xiaohui Li ◽  
Feifei Song ◽  
Hongqiang Sun
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Cancer Cells ◽  
Lymphoblastic Leukemia ◽  
Non Coding Rna ◽  
Proliferation And Apoptosis ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Long Non Coding Rna

scholarly journals The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Haematologica ◽  
2014 ◽  
Vol 99 (12) ◽  
pp. 1808-1816 ◽  
Author(s):  
K. Durinck ◽  
A. Wallaert ◽  
I. Van de Walle ◽  
W. Van Loocke ◽  
P.-J. Volders ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Non Coding Rna ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Long Non Coding Rna

scholarly journals Prognostic significance of protein-coding and long non-coding RNA expression profile in T-cell acute lymphoblastic leukemia

2021 ◽  
Author(s):  
Deepak Verma ◽  
Shruti Kapoor ◽  
Disha Sharma ◽  
Jay Singh ◽  
Gunjan Sharma ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Expression Profile ◽  
Lymphoblastic Leukemia ◽  
High Expression ◽  
Protein Coding ◽  
Non Coding Rna ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Long Non Coding Rna

T-acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy associated with poor outcome. To unravel gene-expression profile of immunophenotypic subtypes of T-ALL, we did transcriptome analysis in 35 cases. We also analyzed the prognostic relevance of 23 targets: protein-coding genes, histone modifiers and long non-coding RNA (lncRNA) expression profile, identified on RNA sequencing, on an independent cohort of 99 T-ALL cases. We found high expression of MEF2C to be associated with prednisolone resistance (p=0.048) and CD34 expression (p=0.012). BAALC expression was associated with expression of CD34 (p=0.032) and myeloid markers (p=0.021). XIST and KDM6a expression levels were higher in females (p=0.047 and 0.011, respectively). Post-induction minimal residual disease (MRD) positivity was associated with high lncRNA PCAT18 (p=0.04), HHEX (p=0.027) and MEF2C (p=0.007). Early thymic precursor (ETP-ALL) immunophenotype was associated with high expression of MEF2C (p=0.003), BAALC (p=0.003), LYL1 (p=0.01), LYN (p=0.01), XIST (p=0.02) and low levels of ST20 (p=0.007) and EML4 (p=0.03). On survival analysis, MEF2C high expression emerged as significant predictor of 3-year event free survival (EFS) (low 71.78+6.58% vs high 36.57+10.74%, HR 3.5, p=0.0003) and overall survival (OS) (low 94.77+2.96% vs high 78.75+8.45%, HR 4.88, p=0.016) in our patients. LncRNA MALAT1 low expression also emerged as predictor inferior OS (low 76.02+10.48 vs high 94.11+3.31, HR 0.22, p=0.027). Keywords: RNA-Sequencing, T-cell acute lymphoblastic Leukemia, Early thymic precursor, LncRNA, Gene expression profile.

scholarly journals Bone marrow ectopic expression of a non-coding RNA in childhood T-cell acute lymphoblastic leukemia with a novel t(2;11)(q11.2;p15.1) translocation

2008 ◽  
Vol 7 (1) ◽  
pp. 80 ◽  
Author(s):  
Maria Guastadisegni ◽  
Angelo Lonoce ◽  
Luciana Impera ◽  
Francesco Albano ◽  
Pietro D'Addabbo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Ectopic Expression ◽  
Non Coding Rna ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals LINC00511 exacerbated T-cell acute lymphoblastic leukemia via miR-195-5p/LRRK1 axis

2020 ◽  
Vol 40 (5) ◽  
Author(s):  
Shengli Li ◽  
Wenwen Guo ◽  
Huayun Geng ◽  
Chao Wang ◽  
Shuige Yang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Mediated Effects ◽  
Proliferation And Apoptosis ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Series Of Experiments ◽  
Non Coding Rnas

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a malignant disease arising from the abnormal proliferation of T lymphocyte in marrow. Long non-coding RNAs (lncRNAs) are one kind of non-coding RNAs (ncRNAs), which were reported to modulate the initiation or progression of diverse cancers. However, the role of LINC00511 in T-ALL was unknown. To figure out the function and mechanism of LINC00511 in T-ALL, a series of experiments were carried out. Based on the experimental results, we discovered that LINC00511 boosted cell proliferation and invasion, but hindered cell apoptosis in T-ALL cells. Besides, based on bio-informatics tool, miR-195-5p was selected for further exploration. Then, miR-195-5p was validated to bind with LINC00511. Hereafter, LRRK1 was testified to serve as a target gene of miR-195-5p. At last, rescue assays suggested that LRRK1 overexpression restored sh-LINC00511#1-mediated effects on cell proliferation and apoptosis. All in all, LINC00511 exacerbated T-ALL progression via miR-195-5p/LRRK1 axis, implying a potential therapeutic clue for the patients with T-ALL.

scholarly journals Ultraconserved long non-coding RNA uc.112 is highly expressed in childhood T versus B-cell acute lymphoblastic leukemia

2020 ◽  
Author(s):  
Pablo Ferreira das Chagas ◽  
Graziella Ribeiro de Sousa ◽  
Márcio Hideki Kodama ◽  
Carlos Alberto Oliveira de Biagi Junior ◽  
José Andres Yunes ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Non Coding Rna ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Long Non Coding Rna
Sign in / Sign up

Export Citation Format

Share Document