scholarly journals Diagnostic and prognostic values of Club cell protein 16 (CC16) in critical care patients with acute respiratory distress syndrome

2017 ◽  
Vol 32 (2) ◽  
pp. e22262 ◽  
Author(s):  
Jinle Lin ◽  
Wenwu Zhang ◽  
Lijun Wang ◽  
Fang Tian
Keyword(s):  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Cell Protein ◽  
Club Cell ◽  
Critical Care Patients

scholarly journals Club Cell Protein, CC10, Attenuates Acute Respiratory Distress Syndrome Induced by Smoke Inhalation

Shock ◽  
2020 ◽  
Vol 53 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Ernesto Lopez ◽  
Osamu Fujiwara ◽  
Christina Nelson ◽  
Melissa E. Winn ◽  
Richard S. Clayton ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Smoke Inhalation ◽  
Cell Protein ◽  
Club Cell

A Pneumatic Compression Vest for Transthoracic Manipulation of Ventilation-Perfusion in Critical Care Patients with Acute Respiratory Distress Syndrome Caused by COVID-19

2020 ◽  
Author(s):  
Alexander B. Ambrose ◽  
Lucas Tiziani ◽  
Donald J. Ward ◽  
Maxwell Weinmann ◽  
Frank L. Hammond
Keyword(s):  
Blood Flow ◽  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Gas Exchange ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Exchange Process ◽  
Significant Risk ◽  
Critical Care Patients

Abstract Critical Care patients who experience symptoms of Acute Respiratory Distress Syndrome (ARDS) are commonly placed on mechanical ventilators to increase the oxygen being supplied to their pulmonary system. If patients’ pulmonary inflammation is severe, they can experience ventilation-perfusion mismatch (V/Q mismatch) where blood flow and gas exchange are mismatched such that oxygen uptake is greatly impaired. In these cases, patients are typically rotated into a prone position to facilitate improved blood flow to segments of the lung that were not previously participating in the gas exchange process. However, proning a patient has a significant risk of complications. The low-cost vest presented in this work is designed to be used as a surrogate to patient proning while also requiring less hospital staff to operate than the proning process. The vest was preliminarily tested on 6 patients with Coronavirus disease 2019 (COVID-19) who experienced ARDS and presumptive V/Q mismatch. The results from this preliminary testing show that 5 out of 6 patients showed a significant increase in ventilation-perfusion similar to the effects of proning.

Glucocorticoid Rescue for Late-Phase Acute Respiratory Distress Syndrome in Trauma/Surgical Critical Care Patients

2006 ◽  
Vol 72 (7) ◽  
pp. 644-648
Author(s):  
Curt S. Koontz ◽  
K. Kye Higdon ◽  
Troy L. Ploger ◽  
Benjamin W. Dart ◽  
Charles M. Richart ◽  
...  
Keyword(s):  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Critically Ill ◽  
Distress Syndrome ◽  
High Dose ◽  
Surgical Critical Care ◽  
Before And After ◽  
Critical Care Patients

High-dose glucocorticoid therapy (GCT) for the late fibroproliferative phase of acute respiratory distress syndrome (ARDS) is controversial and has shown mixed results in medical patients. No studies have evaluated GCT in trauma/surgical critical care patients. The purpose of this study is to review the outcomes of trauma/surgical critical care patients with refractory ARDS treated with GCT. From January 2001 through September 2005, a pharmacy log was used to identify critically ill trauma/surgical patients in refractory ARDS (7 males and 2 females) who received GCT in an attempt to salvage them. GCT consisted of 200 mg intravenous methylprednisolone bolus for one dose and then 3 mg/kg per day divided every 6 hours for 6 weeks or until weaned off the ventilator. All patients as well as the survivors were analyzed. Outcome data was analyzed with SPSS (Chicago, IL) and the paired sample test. A P value ≤0.05 was considered significant. Data is presented as mean ± standard deviation. The Institutional Review Board approved this retrospective chart review. Seven patients (6 males and 1 female; age, 31 ± 16 years) survived (78%), weaned off of the ventilator, and were discharged from the hospital. The 2 deaths were secondary to refractory respiratory failure as well as cardiac arrest (n = 1) and anoxic brain injury from septic hypotension (n = 1). In survivors (n = 7), hospital length of stay (LOS) and intensive care unit LOS was 71 ± 30 days and 53 ± 16 days, respectively. Duration of GCT administration was 17 ± 6.4 days (range, 11–30 days). Ventilator time before GCT, during GCT, and after GCT was 22 ± 8.4, 15 ± 7.5, and 1.6 ± 6.0 days, respectively. During GCT, 8 patients developed pneumonia, 5 had urinary tract infection, and 3 had bacteremia. All infections were effectively treated with broad-spectrum antibiotics, except in one patient who died of sepsis. PaO2/FIO2 ratio just before and after GCT was 100 ± 36 and 247 ± 56, respectively (n = 7; P < 0.001). Sequential organ failure assessment score just before and after GCT was 9.1 ± 2.3 and 5.0 ± 1.6, respectively (n = 7; P < 0.001). GCT rescue may have a role in salvaging critically ill trauma/surgical critical care patients in late-stage ARDS. More patients, however, need to be studied.

Acute respiratory distress syndrome, the critical care paradigm: what we learned and what we forgot

2004 ◽  
Vol 10 (4) ◽  
pp. 272-278 ◽  
Author(s):  
Luciano Gattinoni ◽  
Eleonora Carlesso ◽  
Franco Valenza ◽  
Davide Chiumello ◽  
Maria Luisa Caspani
Keyword(s):  
Critical Care ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome
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