scholarly journals Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion

2016 ◽  
Vol 31 (5) ◽  
pp. e22106 ◽  
Author(s):  
Fan Zhang ◽  
Lijuan Hu ◽  
Junjun Wang ◽  
Jian Chen ◽  
Jie Chen ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Clinical Value

The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion

Respirology ◽  
2003 ◽  
Vol 8 (4) ◽  
pp. 487-491 ◽  
Author(s):  
Jeong-Seon RYU ◽  
Hun-Jae LEE ◽  
Jae-Hwa CHO ◽  
Hye-Seung HAN ◽  
Hong-Lyeol LEE
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Antigen Level

Limited Additive Value of Pleural Fluid Carcinoembryonic Antigen Level in Malignant Pleural Effusion

Respiration ◽  
2000 ◽  
Vol 67 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Pratheep Riantawan ◽  
Piamlarp Sangsayan ◽  
Kittima Bangpattanasiri ◽  
Prapant Rojanaraweewong
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Antigen Level

scholarly journals A retrospective study on the combined biomarkers and ratios in serum and pleural fluid to distinguish the multiple types of pleural effusion

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liyan Lin ◽  
Shuguang Li ◽  
Qiao Xiong ◽  
Hui Wang
Keyword(s):  
Differential Diagnosis ◽  
Retrospective Study ◽  
Pleural Effusion ◽  
Decision Tree ◽  
Pleural Fluid ◽  
Diagnostic Performance ◽  
Connective Tissue Diseases ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Diagnostic Strategy

Abstract Purpose Pleural effusion (PE) is a common clinical manifestation, and millions of people suffer from pleural disease. Herein, this retrospective study was performed to evaluate the biomarkers and ratios in serum and pleural fluid (PF) for the differential diagnosis of the multiple types of PE and search for a new diagnostic strategy for PE. Methods In-patients, who developed tuberculous PE (TPE), malignant PE (MPE), complicated parapneumonic effusion (CPPE), uncomplicated PPE (UPPE), or PE caused by connective tissue diseases (CTDs) and underwent thoracentesis at Peking University People’s Hospital from November 2016 to April 2019, were included in this study. Eleven biomarkers and their ratios in serum and PF were investigated and compared between pairs of the different PE groups, and a decision-tree was developed. Results Totally 112 PE cases, including 25 MPE, 33 TPE, 19 CPPE, 27 UPPE, and 8 PE caused by CTDs, were reviewed. Biomarkers and ratios showed good diagnostic performance with high area under the curve values, sensitivities, and specificities for the differential diagnosis of the multiple types of PE. According to the decision-tree analysis, the combination of adenosine deaminase (ADA), serum albumin, serum lactate dehydrogenase, total protein, PF-LDH/ADA, and PF-LDH/TP provided the best predictive capacity with an overall accuracy of 84.8%; the sensitivity and specificity for TPE diagnosis were 100% and 98.7%, respectively. Conclusion The biomarkers and ratios showed good diagnostic performance, and a decision-tree with an overall accuracy of 84.8% was developed to differentiate the five types of PE in clinical settings.

scholarly journals Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion

2019 ◽  
Vol 11 ◽  
pp. 175883591985034 ◽  
Author(s):  
Klaus Hackner ◽  
Peter Errhalt ◽  
Sabin Handzhiev
Keyword(s):  
Pleural Effusion ◽  
Carcinoembryonic Antigen ◽  
Pleural Fluid ◽  
Predictive Value ◽  
Malignant Pleural Effusion ◽  
Diagnostic Value ◽  
Tumour Markers ◽  
Operating Characteristics ◽  
Characteristics Analysis ◽  
Individual Marker

Background: Tumour markers in pleural fluid and their diagnostic value are subject to debate. Although there are several studies on this topic, standardized cut-off values do not exist. In this study we investigated the potential of a ratio of carcinoembryonic antigen (CEA) in pleural fluid and serum, serving as an individual marker for pleural cancer manifestation. Methods: A total of 201 consecutive patients with unclear pleural effusion were included in the study; 98 were diagnosed with malignant pleural effusion and 103 had an effusion due to other, benign reasons. CEA levels in pleural fluid and serum were measured. Results: By using receiver operating characteristics analysis, at the cut-off of 1.0, the CEA ratio showed a specificity of 92% and sensitivity of 85%, with a positive predictive value of 91% and a negative predictive value of 87%. These results are higher than in previous investigations on different pleural tumour markers and their combination. Conclusions: The CEA ratio is a useful tool in predicting pleural carcinosis. Elevated results in cytology-negative patients should lead to further investigations, such as repeated cytological examination or thoracoscopy.

Pleural Fluid Adenosine Deaminase (ADA) Predicts Survival in Patients with Malignant Pleural Effusion

Lung ◽  
2016 ◽  
Vol 194 (4) ◽  
pp. 681-686 ◽  
Author(s):  
Ricardo Mingarini Terra ◽  
Leila Antonangelo ◽  
Alessandro Wasum Mariani ◽  
Ricardo Lopes Moraes de Oliveira ◽  
Lisete Ribeiro Teixeira ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Adenosine Deaminase ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion
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