scholarly journals Asian multicenter trials on urinary type IV collagen in patients with diabetic nephropathy

2001 ◽  
Vol 15 (4) ◽  
pp. 188-192 ◽  
Author(s):  
Yasuhiko Tomino ◽  
Shigenobu Suzuki ◽  
Chieko Azushima ◽  
Ichiyu Shou ◽  
Toshihiko Iijima ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Type Iv Collagen ◽  
Multicenter Trials ◽  
Type Iv

Synthesis of type III Collagen and type IV collagen by tubular epithelial cells in diabetic nephropathy

1995 ◽  
Vol 191 (11) ◽  
pp. 1099-1104 ◽  
Author(s):  
M.S. Razzaque ◽  
T. Koji ◽  
Y. Horita ◽  
M. Nishihara ◽  
T. Harada ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Epithelial Cells ◽  
Type Iv Collagen ◽  
Type Iii Collagen ◽  
Tubular Epithelial Cells ◽  
Type Iii ◽  
Type Iv

scholarly journals Advanced Glycation End Products Increase Collagen-specific Chaperone Protein in Mouse Diabetic Nephropathy

2004 ◽  
Vol 279 (19) ◽  
pp. 19816-19823 ◽  
Author(s):  
Seiji Ohashi ◽  
Hideharu Abe ◽  
Toshikazu Takahashi ◽  
Yasuhiko Yamamoto ◽  
Masayoshi Takeuchi ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Advanced Glycation End Products ◽  
Type Iv Collagen ◽  
Advanced Glycation ◽  
Type Iv ◽  
Insulin Promoter ◽  
Mesangial Area ◽  
Glycation End Products ◽  
End Products

Advanced glycation end products (AGEs) appear to contribute to the diabetic complications. This study reports the inhibitory effect of OPB-9195 (OPB), an inhibitor of AGEs formation, and the role of a collagen-specific molecular chaperone, a 47-kDa heat shock protein (HSP47) in diabetic nephropathy. Transgenic mice carrying nitric-oxide synthase cDNA fused with insulin promoter (iNOSTg) leads to diabetes mellitus. The iNOSTg mice at 6 months of age represented diffuse glomerulosclerosis, and the expression of HSP47 was markedly increased in the mesangial area in parallel with increased expression of types I and IV collagens. OPB treatment ameliorated glomerulosclerosis in the iNOSTg mice associated with the decreased expression of HSP47 and types I and IV collagens. The expression of transforming growth factor-β (TGF-β) was increased in glomeruli of iNOSTg mice and decreased after treatment with OPB. To confirm these mechanisms, cultured mesangial cells were stimulated with AGEs. AGEs significantly increased the expression of HSP47, type IV collagen, and TGF-β mRNA. Neutralizing antibody for TGF-β inhibited the overexpression of both HSP47 and type IV collagenin vitro. In conclusion, AGEs increase the expression of HSP47 in association with collagens, bothin vivoandin vitro. The processes may be mediated by TGF-β.

scholarly journals Follow-up study on urinary type IV collagen in patients with early stage diabetic nephropathy

1998 ◽  
Vol 12 (6) ◽  
pp. 378-382 ◽  
Author(s):  
Toshihiko Iijima ◽  
Shigenobu Suzuki ◽  
Keiko Sekizuka ◽  
Toshimasa Hishiki ◽  
Mitsunori Yagame ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Type Iv Collagen ◽  
Early Stage ◽  
Follow Up Study ◽  
Type Iv

Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy

2012 ◽  
Vol 302 (5) ◽  
pp. F606-F613 ◽  
Author(s):  
Kyung Don Ju ◽  
Eun Kyoung Shin ◽  
Eun Jin Cho ◽  
Hyun Bae Yoon ◽  
Hyo Sang Kim ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nadph Oxidase ◽  
Type Iv Collagen ◽  
Transforming Growth Factor ◽  
Ethyl Pyruvate ◽  
Reactive Oxygen Species Generation ◽  
Diabetic Rats ◽  
Protective Mechanism ◽  
Type Iv

Pyruvate is an endogenous antioxidant and anti-inflammatory substance. The present study was implemented to investigate the protective effect of ethyl pyruvate (EP) against the development and progression of diabetic nephropathy in an in vivo and in vitro model. Diabetic rats were prepared by injecting streptozotocin (65 mg/kg). Those that developed diabetes after 72 h were treated with EP (40 mg/kg) intraperitoneally. Diabetic rats without pyruvate treatment and nondiabetic rats were used for control. As an in vitro experiment, rat mesangial cells cultured primarily from Sprague-Dawley rats were treated in high-glucose (HG; 50 mM) or normal-glucose (NG; 5 mM) conditions and with or without pyruvate. Pyruvate-treated diabetic rats exhibited decreased albuminuria and attenuated NADPH-dependent reactive oxygen species generation. Immunohistochemistry showed reduced laminin, type IV collagen, and fibronectin deposition in the glomeruli compared with nontreated diabetic rats. Parallel changes were shown in tissue mRNA and protein expression levels of monocyte chemoattractant protein-1, transforming growth factor-β1, laminin, fibronectin, and type IV collagen in the kidney. Concordantly, protective effects were also exhibited in the mesangial cell culture system. These findings suggest that pyruvate protects against kidney injury via NADPH oxidase inhibition. The present study established that activation of NADPH oxidase plays a crucial role in diabetes-induced oxidative stress, glomerular hypertrophy, and ECM molecule expression. Pyruvate exhibited a renoprotective effect in the progression of experimental diabetic nephropathy. Future research is warranted to investigate the protective mechanism of pyruvate more specifically in relation to NADPH oxidase in diabetic nephropathy.

Urinary type IV collagen as a marker for early diabetic nephropathy

1996 ◽  
Vol 31 (1-3) ◽  
pp. 103-108 ◽  
Author(s):  
Seijiro Kado ◽  
Akira Aoki ◽  
Seiki Wada ◽  
Yasuyuki Katayama ◽  
Nobuo Kugai ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Type Iv Collagen ◽  
Type Iv ◽  
Early Diabetic Nephropathy

In situ localization of type III and type IV collagen-expressing cells in human diabetic nephropathy

1994 ◽  
Vol 174 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Mohammed S. Razzaque ◽  
Takehiko Koji ◽  
Takashi Taguchi ◽  
Takashi Harada ◽  
Paul K. Nakane
Keyword(s):  
Diabetic Nephropathy ◽  
Type Iv Collagen ◽  
Type Iii ◽  
Type Iv
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