Synergistic antitumor activity of oridonin and valproic acid on HL‐60 leukemia cells

2018 ◽  
Vol 120 (4) ◽  
pp. 5620-5627 ◽  
Author(s):  
Wei Li ◽  
LiEn Ma
Keyword(s):  
Valproic Acid ◽  
Antitumor Activity ◽  
Leukemia Cells ◽  
Synergistic Antitumor Activity

scholarly journals In VitroAntileukemic Activity ofXanthosoma sagittifolium(Taioba) Leaf Extract

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Marina L. C. Caxito ◽  
Rachell R. Correia ◽  
Anne Caroline C. Gomes ◽  
Graça Justo ◽  
Marsen G. P. Coelho ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Leaf Extract ◽  
Leukemia Cells ◽  
No Production ◽  
3T3 Fibroblasts ◽  
Griess Reaction ◽  
Xanthosoma Sagittifolium ◽  
M Phase ◽  
Nih 3T3

Xanthosoma sagittifoliumSchott is a herb of the Araceae family, popularly known as taioba, which is consumed as food in some regions of Brazil, Africa, and Asia. This species has already been evaluated for the antifungal activities. However, based on its potential antitumor activity, the present study further aimed to examine the antitumor, as well as chelation, activity ofX. sagittifoliumleaf extract. Results showed that hydroethanolic extract ofX. sagittifoliumleaves (HEXs-L) exhibits cytotoxic effects against the immortalized line of human T-lymphocytic (Jurkat) and myelogenous (K562) leukemia cells, but not nontumor RAW 264.7 macrophages or NIH/3T3 fibroblasts. HEXs-L inhibited 50.3% of Jurkat cell proliferation, reducing by 20% cells in G2/M phase, but increasing cells in sub-G1 phase, thereby inducing apoptosis by 54%. In addition, HEXs-L inhibited NO production by 59%, as determined by Griess reaction, and chelated 93.8% of free Fe(II), as demonstrated by ferrozine assay. Phytochemical studies were carried out by ESI-MS, identifying apigenin di-C-glycosides as major compounds. Overall, this work revealed that leaf extract ofXanthosoma sagittifoliumpresented chelating activity andin vitroantitumor activity, arresting cell cycle and inducing apoptosis of leukemia cells, thus providing evidence that taioba leaves may have practical application in cancer therapy.

Intracellular Responses of Hybrid Liposomes against Leukemia Cells Related to Apoptosis with Antitumor Activity

1999 ◽  
Vol 28 (1) ◽  
pp. 53-54 ◽  
Author(s):  
Yoko Matsumoto ◽  
Toshihiro Kato ◽  
Yoshinori Kemura ◽  
Makoto Tsuchiya ◽  
Megumi Yamamoto ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Leukemia Cells

Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells

2010 ◽  
Vol 41 (2) ◽  
pp. 210-218 ◽  
Author(s):  
Jie Chen ◽  
Guiying Wang ◽  
Libing Wang ◽  
Jiuhong Kang ◽  
Jianmin Wang
Keyword(s):  
Valproic Acid ◽  
Anticancer Activity ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells
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