LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway

2018 ◽  
Vol 120 (3) ◽  
pp. 4172-4179 ◽  
Author(s):  
Yong‐Fa Zheng ◽  
Xiao‐Yu Zhang ◽  
Yan‐Zhi Bu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Akt Pathway

scholarly journals LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway

2013 ◽  
Vol 12 (1) ◽  
pp. 114 ◽  
Author(s):  
Xuan Song ◽  
Jiabei Wang ◽  
Tongsen Zheng ◽  
Ruipeng Song ◽  
Yingjian Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Akt Pathway ◽  
Proliferation And Metastasis

scholarly journals Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells

2017 ◽  
Vol 41 (4) ◽  
pp. 1519-1531 ◽  
Author(s):  
Beibei Bie ◽  
Jin Sun ◽  
Jun Li ◽  
Ying Guo ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Mirna Expression ◽  
Expression Profiles ◽  
Akt Pathway ◽  
Qrt Pcr ◽  
Cycle Arrest ◽  
Mirna Expression Profiles

Background/Aims: Baicalein has been shown to possess significant anti-hepatoma activity by inhibiting cell proliferation. Whether the anti-proliferative effect of baicalein is related to its modulation of miRNA expression in hepatocellular carcinoma (HCC) is still unknown. Methods: The anti-proliferative effects of baicalein on HCC cell line Bel-7402 was assessed by detecting the proliferation activity, cell cycle distribution, expression changes of p21/CDKN1A, P27/CDKN1B, total Akt and phosphoryted AKT. Microarray analysis was conducted to determine the miRNA expression profiles in baicalein-treated or untreated Bel-7402 cells and then validated by qRT-PCR in two HCC cell lines (Bel-7402 and Hep3B). The gain-of-function of miR-3127-5p was performed by detecting anti-proliferative effects after transfecting miRNA mimics in cells. Finally, the expression level of miR-3127-5p in different HCC cell lines was determined by qRT-PCR. Results: Baicalein was able to inhibit the proliferation of Bel-7402 cells by inducing cell cycle arrest at the S and G2/M phase via up-regulating the expression of p21/CDKN1A and P27/CDKN1B and suppressing the PI3K/Akt pathway. Baicalein could alter the miRNA expression profiles in Bel-7402 cells. Putative target genes for differentially expressed miRNAs could be enriched in terms of cell proliferation regulation, cell cycle arrest and were mainly involved in MAPK, PI3K-Akt, Wnt, Hippo and mTOR signaling pathways. MiR- 3127-5p, one of up-regulated miRNAs, exhibits low expression level in several HCC cell lines and its overexpression could inhibit cell growth of Bel-7402 and Hep3B cell lines by inducing S phase arrest by up-regulating the expression of p21and P27 and repressing the PI3K/Akt pathway. Conclusions: Modulation of miRNA expression may be an important mechanism underlying the anti-hepatoma effects of baicalein.

scholarly journals MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma

Hepatology ◽  
2012 ◽  
Vol 55 (6) ◽  
pp. 1852-1862 ◽  
Author(s):  
YuXiang Fang ◽  
Jing-Lun Xue ◽  
Qi Shen ◽  
Jinzhong Chen ◽  
Ling Tian
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Akt Pathway ◽  
Tumor Growth And Metastasis ◽  
Phosphoinositide 3 Kinase

LINC00707 promotes hepatocellular carcinoma progression through activating ERK/JNK/AKT pathway signaling pathway

2018 ◽  
Vol 234 (5) ◽  
pp. 6908-6916 ◽  
Author(s):  
Jianchu Wang ◽  
Zongjiang Luo ◽  
Tianwei Yao ◽  
Wenchuan Li ◽  
Jian Pu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Akt Pathway

PES1 enhances proliferation and tumorigenesis in hepatocellular carcinoma via the PI3K/AKT pathway

Life Sciences ◽  
2019 ◽  
Vol 219 ◽  
pp. 182-189 ◽  
Author(s):  
Jing Wang ◽  
Jie Sun ◽  
Na Zhang ◽  
Renjun Yang ◽  
Huixian Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Akt Pathway

scholarly journals miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hua Li ◽  
Shen Shen ◽  
Xiaolong Chen ◽  
Zhigang Ren ◽  
Zhiqin Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Akt Pathway
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