Upregulated long noncoding RNA LINC01296 indicates a dismal prognosis for pancreatic ductal adenocarcinoma and promotes cell metastatic properties by affecting EMT

2018 ◽  
Vol 120 (1) ◽  
pp. 552-561 ◽  
Author(s):  
Qihua Yuan ◽  
Yuxia Zhang ◽  
Lijun Feng ◽  
Yuehong Jiang
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma ◽  
Dismal Prognosis

scholarly journals Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Huakai Wang ◽  
Shiyong Yu ◽  
Huan Peng ◽  
Yijun Shu ◽  
Wenjie Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma ◽  
Regulation Mechanism ◽  
Clinical Value ◽  
Dismal Prognosis

Abstract Background Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance and role in pancreatic ductal adenocarcinoma (PDAC) progression remains largely unknown. Methods Multiple approaches such as bioinformatic analysis, Transfection, quantitative real-time-PCR, Western blotting, animal studies, RNA-immunoprecipitation (RIP), RNA-pulldown and RNA-Fluorescence in situ hybridization (RNA-FISH) and were utilized to explore the role of Linc00337 in PDAC. Results Here we identified Linc00337 is an oncogenic lncRNA during PDAC progression. We found that the expression of Linc00337 is elevated in PDAC tissues and the higher Linc00337 predicts dismal prognosis. Functionally, Linc00337 promotes PDAC cell proliferation and cell cycle transition both in vitro and in vivo. Mechanistically, Linc00337 binds to E2F1 and functions as an E2F1 coactivator to trigger the targets expression during PDAC progression. Conclusion Our results demonstrate a reciprocal regulation mechanism between Linc00337 and E2F1 in PDAC progression and report the clinical value of Linc00337 for PDAC prognosis and treatment.

Long noncoding RNA DLEU1 aggravates pancreatic ductal adenocarcinoma carcinogenesis via the miR-381/CXCR4 axis

2018 ◽  
Vol 234 (5) ◽  
pp. 6746-6757 ◽  
Author(s):  
Song Gao ◽  
Yunyun Cai ◽  
Hu Zhang ◽  
Fei Hu ◽  
Lengchen Hou ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma ◽  
Cxcr4 Axis

scholarly journals Analysis of distinct long noncoding RNA transcriptional fingerprints in pancreatic ductal adenocarcinoma

2017 ◽  
Vol 6 (3) ◽  
pp. 673-680 ◽  
Author(s):  
Xiang Yu ◽  
Yang Lin ◽  
Wu Sui ◽  
Yanfen Zou ◽  
Zhongchuan Lv
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma

scholarly journals Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma

2018 ◽  
Vol 9 (2) ◽  
pp. 389-399 ◽  
Author(s):  
Ling Ma ◽  
Xiaodong Tian ◽  
Huahu Guo ◽  
Zhengkui Zhang ◽  
Chong Du ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma

scholarly journals Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96

2019 ◽  
Vol 110 (9) ◽  
pp. 2760-2772 ◽  
Author(s):  
Yufeng Zhang ◽  
Haiyan Yang ◽  
Yong Du ◽  
Pingping Liu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma
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