Downregulation of long noncoding RNA SNHG14 suppresses cell proliferation and invasion by regulating EZH2 in pancreatic ductal adenocarcinoma (PDAC)

2020 ◽  
Vol 27 (3) ◽  
pp. 357-364 ◽  
Author(s):  
Fang Xie ◽  
Qiang Huang ◽  
Cheng Wang ◽  
Sanwei Chen ◽  
Chenhai Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma ◽  
Proliferation And Invasion

scholarly journals Long noncoding RNA H19 derived miR-675 regulates cell proliferation by down-regulating E2F-1 in human pancreatic ductal adenocarcinoma

2018 ◽  
Vol 9 (2) ◽  
pp. 389-399 ◽  
Author(s):  
Ling Ma ◽  
Xiaodong Tian ◽  
Huahu Guo ◽  
Zhengkui Zhang ◽  
Chong Du ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma

scholarly journals The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma

2016 ◽  
Vol 17 (10) ◽  
pp. 1051-1061 ◽  
Author(s):  
Ling Ma ◽  
Xiaodong Tian ◽  
Feng Wang ◽  
Zhengkui Zhang ◽  
Chong Du ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma

scholarly journals Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Huakai Wang ◽  
Shiyong Yu ◽  
Huan Peng ◽  
Yijun Shu ◽  
Wenjie Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma ◽  
Regulation Mechanism ◽  
Clinical Value ◽  
Dismal Prognosis

Abstract Background Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance and role in pancreatic ductal adenocarcinoma (PDAC) progression remains largely unknown. Methods Multiple approaches such as bioinformatic analysis, Transfection, quantitative real-time-PCR, Western blotting, animal studies, RNA-immunoprecipitation (RIP), RNA-pulldown and RNA-Fluorescence in situ hybridization (RNA-FISH) and were utilized to explore the role of Linc00337 in PDAC. Results Here we identified Linc00337 is an oncogenic lncRNA during PDAC progression. We found that the expression of Linc00337 is elevated in PDAC tissues and the higher Linc00337 predicts dismal prognosis. Functionally, Linc00337 promotes PDAC cell proliferation and cell cycle transition both in vitro and in vivo. Mechanistically, Linc00337 binds to E2F1 and functions as an E2F1 coactivator to trigger the targets expression during PDAC progression. Conclusion Our results demonstrate a reciprocal regulation mechanism between Linc00337 and E2F1 in PDAC progression and report the clinical value of Linc00337 for PDAC prognosis and treatment.

Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6801-6812 ◽  
Author(s):  
Su-xiu Chen ◽  
Jun-feng Yin ◽  
Bao-chai Lin ◽  
Hua-fang Su ◽  
Zhen Zheng ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Proliferation And Invasion

Long noncoding RNA DLEU1 aggravates pancreatic ductal adenocarcinoma carcinogenesis via the miR-381/CXCR4 axis

2018 ◽  
Vol 234 (5) ◽  
pp. 6746-6757 ◽  
Author(s):  
Song Gao ◽  
Yunyun Cai ◽  
Hu Zhang ◽  
Fei Hu ◽  
Lengchen Hou ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Ductal Adenocarcinoma ◽  
Cxcr4 Axis

scholarly journals Long Noncoding RNA RC3H2 Facilitates Cell Proliferation and Invasion by Targeting MicroRNA-101-3p/EZH2 Axis in OSCC

2020 ◽  
Vol 20 ◽  
pp. 97-110 ◽  
Author(s):  
Kun Wu ◽  
Yingying Jiang ◽  
Wenkai Zhou ◽  
Bolin Zhang ◽  
Yan Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Proliferation And Invasion
Sign in / Sign up

Export Citation Format

Share Document