Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8‐AS1‐N

2018 ◽  
Vol 119 (8) ◽  
pp. 6842-6856 ◽  
Author(s):  
Xiaolan Yu ◽  
Yong Cao ◽  
Li Tang ◽  
Yingcheng Yang ◽  
Feng Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yujuan Kang ◽  
Lin Wan ◽  
Qin Wang ◽  
Yanling Yin ◽  
Jiena Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Malignant Tumors ◽  
Inhibitory Effect ◽  
Positive Role ◽  
Breast Cancer Growth ◽  
Tert Expression

Abstract Background Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a positive role in the progression of human malignant tumors. However, the molecular mechanism of SNHG1 remains elusive in breast cancer. Results LncRNA SNHG1 was upregulated and had a positive relationship with poor prognosis according to bioinformatics analysis in pan-cancer including breast cancer. Silencing SNHG1 inhibited tumorigenesis in breast cancer both in vitro and in vivo. Mechanistically, SNHG1 functioned as a competing endogenous RNA (ceRNA) to promote TERT expression by sponging miR-18b-5p in breast cancer. miR-18b-5p acted as a tumor repressor in breast cancer. Moreover, the combination of SNHG1 knockdown and TERT inhibitor administration showed a synergistic inhibitory effect on breast cancer growth in vivo. Finally, E2F1 as a transcription factor, binding to SNHG1 promoter and enhanced SNHG1 transcription in breast cancer. Conclusions Our results provide a comprehensive understanding of the oncogenic mechanism of lncRNA SNHG1 in breast cancer. Importantly, we identified a novel E2F1–SNHG1–miR-18b-5p–TERT axis, which may be a potential therapeutic target for breast cancer. Our results also provided a potential treatment for breast cancer when knockdown SNHG1 and TERT inhibitor administration simultaneously.

Combined Treatment with Exendin-4 and Metformin Attenuates Breast Cancer Growth

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1227-P
Author(s):  
CHIKAYO IWAYA ◽  
TAKASHI NOMIYAMA ◽  
TAKAKO KAWANAMI ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combined Treatment ◽  
Cancer Growth ◽  
Breast Cancer Growth
Sign in / Sign up

Export Citation Format

Share Document