Amyloid Precursor Protein Underwent Proteolytic Cleavage by ADAM10 and Mediated Breast Cancer Growth and Migration

2018 ◽  
Author(s):  
Julia Y. S. Tsang ◽  
Michelle A. Lee ◽  
Tsz-Hei Chan ◽  
Joshua Li ◽  
Yun-Bi Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amyloid Precursor Protein ◽  
Proteolytic Cleavage ◽  
Precursor Protein ◽  
Cancer Growth ◽  
And Migration ◽  
Breast Cancer Growth

scholarly journals Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer

EBioMedicine ◽  
2018 ◽  
Vol 38 ◽  
pp. 89-99 ◽  
Author(s):  
Julia Y.S. Tsang ◽  
Michelle A. Lee ◽  
Tsz-Hei Chan ◽  
Joshua Li ◽  
Yun-Bi Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amyloid Precursor Protein ◽  
Proteolytic Cleavage ◽  
Precursor Protein ◽  
And Migration ◽  
Proliferation And Migration

221 FER Kinase Promotes Breast Cancer Growth and Metastasis by Regulating Cell Adhesion and Migration

2012 ◽  
Vol 48 ◽  
pp. S54
Author(s):  
I.A. Ivanova ◽  
J.F. Vermeulen ◽  
C. Ercan ◽  
J.M. Houthuijzen ◽  
F. Al Saig ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Growth ◽  
Cell Adhesion And Migration ◽  
And Migration ◽  
Breast Cancer Growth

Negative role of trihydrophobin 1 in breast cancer growth and migration

2010 ◽  
Vol 101 (10) ◽  
pp. 2156-2162 ◽  
Author(s):  
Weiying Zou ◽  
Yanzhong Yang ◽  
Yihong Wu ◽  
Linlin Sun ◽  
Yayun Chi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Growth ◽  
Negative Role ◽  
And Migration ◽  
Breast Cancer Growth

scholarly journals A New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF-κB-Dependent TNFαProduction in Macrophages

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Sang-Mi Woo ◽  
Youn Kyung Choi ◽  
Sung-Gook Cho ◽  
Sunju Park ◽  
Seong-Gyu Ko
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Pulmonary Metastasis ◽  
Astragalus Membranaceus ◽  
Cancer Growth ◽  
Xenograft Tumor ◽  
Angelica Gigas ◽  
And Migration ◽  
Breast Cancer Growth ◽  
Proliferation And Migration

Tumor-associated macrophages (TAMs) in tumor microenvironment regulate cancer progression and metastases. In breast cancer, macrophage infiltration is correlated with a poor prognosis. While metastatic breast cancer is poor prognostic with a severe mortality, therapeutic options are still limited. In this study, we demonstrate that KSG-002, a new herbal composition of radicesAstragalus membranaceusandAngelica gigas, suppresses breast cancer via inhibiting TAM recruitment. KSG-002, an extract of radicesAstragalus membranaceusandAngelica gigasat 3 : 1 ratio, respectively, inhibited MDA-MB-231 xenograft tumor growth and pulmonary metastasis in nude mice, while KSG-001, another composition (1 : 1 ratio,w/w), enhanced tumor growth, angiogenesis, and pulmonary metastasis,in vivo. KSG-002 further decreased the infiltrated macrophage numbers in xenograft tumor cohorts. In Raw264.7 cells, KSG-002 but not KSG-001 inhibited cell proliferation and migration and reduced TNF-alpha (TNFα) production by inhibiting NF-κB pathway. Furthermore, a combinatorial treatment of KSG-002 with TNFαinhibited a proliferation and migration of both MDA-MB-231 and Raw264.7 cells. Taken together, we conclude that KSG-002 suppresses breast cancer growth and metastasis through targeting NF-κB-mediated TNFαproduction in macrophages.

Combined Treatment with Exendin-4 and Metformin Attenuates Breast Cancer Growth

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1227-P
Author(s):  
CHIKAYO IWAYA ◽  
TAKASHI NOMIYAMA ◽  
TAKAKO KAWANAMI ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Combined Treatment ◽  
Cancer Growth ◽  
Breast Cancer Growth
Sign in / Sign up

Export Citation Format

Share Document