Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line

1991 ◽  
Vol 45 (2) ◽  
pp. 196-206 ◽  
Author(s):  
Jaime F. Modiano ◽  
Yasuo Kokai ◽  
David B. Weiner ◽  
Mark J. Pykett ◽  
Peter C. Nowell ◽  
...  
1988 ◽  
Vol 116 (3) ◽  
pp. 451-455 ◽  
Author(s):  
R. Kurokawa ◽  
S. Kyakumoto ◽  
M. Ota

ABSTRACT The treatment of a human submandibular gland adenocarcinoma cell line (HSG cell line) for 48 h with triamcinolone acetonide (TA; 1–100 nmol/l) reduced the secretion of epidermal growth factor (EGF) in a closely related manner to a maximum of 66%. The reduction in the level of EGF secreted resulted in the suppression of DNA synthesis in the HSG cells to a similar extent. When the cells were incubated with TA and exogenous human EGF (hEGF), DNA synthesis was 1·7-fold higher than that without added hEGF. The removal of EGF by the addition of hEGF antibody reduced DNA synthesis in HSG cell cultures to the same extent as did TA. These results suggest that the growth inhibition of HSG cells by TA is due to the reduction in the amount of EGF secreted. J. Endocr. (1988) 116, 451–455


1984 ◽  
Vol 2 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Pier-Luigi Lollini ◽  
Carla De Giovanni ◽  
Vincenzo Eusebi ◽  
Giordano Nicoletti ◽  
Giorgio Prodi ◽  
...  

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