scholarly journals Ethanol differentially regulates snail family of transcription factors and invasion of premalignant and malignant pancreatic ductal cells

2011 ◽  
Vol 112 (10) ◽  
pp. 2966-2973 ◽  
Author(s):  
Sarah T. Ward ◽  
Surabhi Dangi-Garimella ◽  
Mario A. Shields ◽  
Brett A. Collander ◽  
Mohammed A.Q. Siddiqui ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Ductal Cells ◽  
Pancreatic Ductal Cells ◽  
Snail Family

Ductal Cell Reprogramming to Insulin-Producing Beta-Like Cells as a Potential Beta Cell Replacement Source for Chronic Pancreatitis

2019 ◽  
Vol 14 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Aravinth P. Jawahar ◽  
Siddharth Narayanan ◽  
Gopalakrishnan Loganathan ◽  
Jithu Pradeep ◽  
Gary C. Vitale ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Beta Cell ◽  
Lineage Tracing ◽  
Clinical Tool ◽  
Glucose Levels ◽  
Ductal Cells ◽  
Pancreatic Ductal Cells ◽  
Insulin Producing Cells ◽  
Ductal Cell ◽  
Recent Advances

Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic pancreatitis (CP). Despite the many recent advances associated with this therapy, obtaining a good yield of islet infusate still remains a pressing challenge. Reprogramming technology, by making use of the pancreatic exocrine compartment, can open the possibility of generating novel insulin-producing cells. Several lineage-tracing studies present evidence that exocrine cells undergo dedifferentiation into a progenitor-like state from which they can be manipulated to form insulin-producing cells. This review will present an overview of recent reports that demonstrate the potential of utilizing pancreatic ductal cells (PDCs) for reprogramming into insulin- producing cells, focusing on the recent advances and the conflicting views. A large pool of ductal cells is released along with islets during the human islet isolation process, but these cells are separated from the pure islets during the purification process. By identifying and improving existing ductal cell culture methods and developing a better understanding of mechanisms by which these cells can be manipulated to form hormone-producing islet-like cells, PDCs could prove to be a strong clinical tool in providing an alternative beta cell source, thus helping CP patients maintain their long-term glucose levels.

Endocrine pancreatic tissue plasticity in obese humans is associated with cytoplasmic expression of PBX-1 in pancreatic ductal cells

2005 ◽  
Vol 333 (4) ◽  
pp. 1153-1159 ◽  
Author(s):  
Ghaffar Muharram ◽  
Anthony Beucher ◽  
Ericka Moerman ◽  
Sandrine Belaı¨ch ◽  
Valéry Gmyr ◽  
...  
Keyword(s):  
Pancreatic Tissue ◽  
Cytoplasmic Expression ◽  
Ductal Cells ◽  
Pancreatic Ductal Cells

Potential role for SNAIL family transcription factors in the etiology of Crohnʼs disease-associated fistulae

2011 ◽  
Vol 17 (9) ◽  
pp. 1907-1916 ◽  
Author(s):  
Michael Scharl ◽  
Achim Weber ◽  
Alois Fürst ◽  
Stefan Farkas ◽  
Ekkehard Jehle ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Potential Role ◽  
Snail Family

Allelic regulation of CK19 during maturation of pancreatic ductal cells

2021 ◽  
Author(s):  
J Krüger ◽  
M Breunig ◽  
T Seufferlein ◽  
M Hohwieler ◽  
A Kleger
Keyword(s):  
Ductal Cells ◽  
Pancreatic Ductal Cells ◽  
Allelic Regulation

668 Vitamin D receptor and colon cancer: effect of the Snail family of transcription factors

2010 ◽  
Vol 8 (5) ◽  
pp. 169
Author(s):  
M.J. Larriba ◽  
F. Pereira ◽  
A. Barbáchano ◽  
H.G. Pálmer ◽  
F. Bonilla ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin D ◽  
Transcription Factors ◽  
Vitamin D Receptor ◽  
Snail Family
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