Potential role for SNAIL family transcription factors in the etiology of Crohnʼs disease-associated fistulae

2011 ◽  
Vol 17 (9) ◽  
pp. 1907-1916 ◽  
Author(s):  
Michael Scharl ◽  
Achim Weber ◽  
Alois Fürst ◽  
Stefan Farkas ◽  
Ekkehard Jehle ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Potential Role ◽  
Snail Family

668 Vitamin D receptor and colon cancer: effect of the Snail family of transcription factors

2010 ◽  
Vol 8 (5) ◽  
pp. 169
Author(s):  
M.J. Larriba ◽  
F. Pereira ◽  
A. Barbáchano ◽  
H.G. Pálmer ◽  
F. Bonilla ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Vitamin D ◽  
Transcription Factors ◽  
Vitamin D Receptor ◽  
Snail Family

scholarly journals New functions for the Snail family of transcription factors: Two-faced proteins

Cell Cycle ◽  
2010 ◽  
Vol 9 (14) ◽  
pp. 2731-2739 ◽  
Author(s):  
Jesús Pérez-Losada ◽  
Isidro Sanchez-García
Keyword(s):  
Transcription Factors ◽  
Snail Family

scholarly journals Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila

PLoS Genetics ◽  
2019 ◽  
Vol 15 (11) ◽  
pp. e1008487
Author(s):  
Ying Liu ◽  
Hong Bao ◽  
Weidong Wang ◽  
Hui-Ying Lim
Keyword(s):  
Transcription Factors ◽  
Lipid Metabolism ◽  
Snail Family

scholarly journals The emerging role of C/EBPs in glucocorticoid signaling: lessons from the lung

2011 ◽  
Vol 212 (3) ◽  
pp. 291-305 ◽  
Author(s):  
Abraham B Roos ◽  
Magnus Nord
Keyword(s):  
Transcription Factors ◽  
Potential Role ◽  
Current Knowledge ◽  
Inflammatory Diseases ◽  
Steroid Resistance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Glucocorticoid Signaling ◽  
Enhancer Binding Protein

Glucocorticoids (GCs) have been successfully used in the treatment of inflammatory diseases for decades. However, there is a relative GC resistance in several inflammatory lung disorders, such as chronic obstructive pulmonary disease (COPD), but still the mechanism(s) behind this unresponsiveness remains unknown. Interaction between transcription factors and the GC receptor contribute to GC effects but may also provide mechanisms explaining steroid resistance. CCAAT/enhancer-binding protein (C/EBP) transcription factors are important regulators of pulmonary gene expression and have been implicated in inflammatory lung diseases such as asthma, pulmonary fibrosis, cystic fibrosis, sarcoidosis, and COPD. In addition, several studies have indicated a role for C/EBPs in mediating GC effects. In this review, we discuss the different mechanisms of GC action as well as the function of the lung-enriched members of the C/EBP transcription factor family. We also summarize the current knowledge of the role of C/EBP transcription factors in mediating the effects of GCs, with emphasis on pulmonary effects, and their potential role in mediating GC resistance.

The Potential Role of Sterol Regulatory Element Binding Protein Transcription Factors in Renal Injury

2007 ◽  
Vol 17 (1) ◽  
pp. 62-65 ◽  
Author(s):  
Marek Szolkiewicz ◽  
Michal Chmielewski ◽  
Anna Nogalska ◽  
Ewa Stelmanska ◽  
Julian Swierczynski ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Renal Injury ◽  
Potential Role ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Protein Transcription

scholarly journals Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription

Blood ◽  
1993 ◽  
Vol 81 (12) ◽  
pp. 3234-3241 ◽  
Author(s):  
LI Zon ◽  
Y Yamaguchi ◽  
K Yee ◽  
EA Albee ◽  
A Kimura ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Gene Transcription ◽  
Butyric Acid ◽  
Binding Proteins ◽  
Potential Role ◽  
Interleukin 5

The expression of the hematopoietic transcription factors GATA-1, GATA- 2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins.

Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo

Development ◽  
1998 ◽  
Vol 125 (16) ◽  
pp. 3111-3121 ◽  
Author(s):  
M. Sefton ◽  
S. Sanchez ◽  
M.A. Nieto
Keyword(s):  
Transcription Factors ◽  
Amino Acid ◽  
Chick Embryo ◽  
Neural Crest ◽  
Family Member ◽  
Zinc Finger ◽  
Mouse Embryo ◽  
Amino Acid Sequences ◽  
Mouse Homologue ◽  
Snail Family

The members of the Snail family of zinc-finger transcription factors have been implicated in the formation of distinct tissues within the developing vertebrate and invertebrate embryo. Two members of this family have been described in higher vertebrates, Snail (Sna) and Slug (Slu), where they have been implicated in the formation of tissues such as the mesoderm and the neural crest. We have isolated the mouse homologue of the Slu gene enabling us to analyse and compare the amino acid sequences and the patterns of expression of both Sna and Slu in the chick and mouse. We have detected features in the sequences that allow the unequivocal ascription of any family member to the Sna or Slu subfamilies and we have observed that, during early stages of development, many of the sites of Slu and Sna expression in the mouse and chick embryo are swapped. Later in development, the sites of expression of Slu and Sna are conserved between these two species. These data, together with the data available in other species, lead us to propose that Slu and Sna arose as a duplication of an ancestor gene and that an extra duplication in the fish lineage has given rise to two Sna genes. Furthermore, several early sites of Slu and Sna expression have been swapped in the avian lineage. Our analysis of the Snail family may also shed new light on the origin of the neural crest.

scholarly journals Ethanol differentially regulates snail family of transcription factors and invasion of premalignant and malignant pancreatic ductal cells

2011 ◽  
Vol 112 (10) ◽  
pp. 2966-2973 ◽  
Author(s):  
Sarah T. Ward ◽  
Surabhi Dangi-Garimella ◽  
Mario A. Shields ◽  
Brett A. Collander ◽  
Mohammed A.Q. Siddiqui ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Ductal Cells ◽  
Pancreatic Ductal Cells ◽  
Snail Family
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