Retinol (vitamin A) maintains self-renewal of pluripotent male germline stem cells (mGSCs) from adult mouse testis

2011 ◽  
Vol 112 (4) ◽  
pp. 1009-1021 ◽  
Author(s):  
Shanshan Zhang ◽  
Junwei Sun ◽  
Shaohui Pan ◽  
Haijing Zhu ◽  
Long Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Vitamin A ◽  
Adult Mouse ◽  
Mouse Testis ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Male Germline ◽  
Male Germline Stem Cells

scholarly journals Functional Assessment of Self-Renewal Activity of Male Germline Stem Cells Following Cytotoxic Damage and Serial Transplantation1

2003 ◽  
Vol 68 (5) ◽  
pp. 1801-1807 ◽  
Author(s):  
Mito Kanatsu-Shinohara ◽  
Shinya Toyokuni ◽  
Takeshi Morimoto ◽  
Shigeyuki Matsui ◽  
Tasuku Honjo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Functional Assessment ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Male Germline ◽  
Male Germline Stem Cells

scholarly journals Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells

2012 ◽  
Vol 23 (8) ◽  
pp. 1524-1532 ◽  
Author(s):  
Therese M. Roth ◽  
C.-Y. Ason Chiang ◽  
Mayu Inaba ◽  
Hebao Yuan ◽  
Viktoria Salzmann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Stem Cell Regulation ◽  
Male Germline ◽  
Male Germline Stem Cells ◽  
Nutrient Conditions

Drosophila male germline stem cells (GSCs) divide asymmetrically, balancing self-renewal and differentiation. Although asymmetric stem cell division balances between self-renewal and differentiation, it does not dictate how frequently differentiating cells must be produced. In male GSCs, asymmetric GSC division is achieved by stereotyped positioning of the centrosome with respect to the stem cell niche. Recently we showed that the centrosome orientation checkpoint monitors the correct centrosome orientation to ensure an asymmetric outcome of the GSC division. When GSC centrosomes are not correctly oriented with respect to the niche, GSC cell cycle is arrested/delayed until the correct centrosome orientation is reacquired. Here we show that induction of centrosome misorientation upon culture in poor nutrient conditions mediates slowing of GSC cell proliferation via activation of the centrosome orientation checkpoint. Consistently, inactivation of the centrosome orientation checkpoint leads to lack of cell cycle slowdown even under poor nutrient conditions. We propose that centrosome misorientation serves as a mediator that transduces nutrient information into stem cell proliferation, providing a previously unappreciated mechanism of stem cell regulation in response to nutrient conditions.

Pluripotent Male Germline Stem Cells from Goat Fetal Testis and Their Survival in Mouse Testis

2011 ◽  
Vol 13 (2) ◽  
pp. 133-144 ◽  
Author(s):  
Jinlian Hua ◽  
Haijing Zhu ◽  
Shaohui Pan ◽  
Chao Liu ◽  
Junwei Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mouse Testis ◽  
Germline Stem Cells ◽  
Fetal Testis ◽  
Male Germline ◽  
Male Germline Stem Cells

scholarly journals p38 MAPK pathway is essential for self-renewal of mouse male germline stem cells (mGSCs)

2016 ◽  
Vol 50 (1) ◽  
pp. e12314 ◽  
Author(s):  
Zhiwei Niu ◽  
Hailong Mu ◽  
Haijing Zhu ◽  
Jiang Wu ◽  
Jinlian Hua
Keyword(s):  
Stem Cells ◽  
P38 Mapk ◽  
Mapk Pathway ◽  
Germline Stem Cells ◽  
Self Renewal ◽  
Male Germline ◽  
P38 Mapk Pathway ◽  
Male Germline Stem Cells
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