Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases

2002 ◽  
Vol 88 (2) ◽  
pp. 227-233 ◽  
Author(s):  
Luciano Adorini ◽  
Giuseppe Penna ◽  
Nadia Giarratana ◽  
Milan Uskokovic
Keyword(s):  
Vitamin D ◽  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Autoimmune Diseases ◽  
Vitamin D Receptor ◽  
Allograft Rejection ◽  
Receptor Ligands ◽  
Tolerogenic Dendritic Cells

scholarly journals Emerging Cellular Therapies for Anti-myeloperoxidase Vasculitis and Other Autoimmune Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Dragana Odobasic ◽  
Stephen R. Holdsworth
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Dendritic Cells ◽  
Autoimmune Disease ◽  
Regulatory T Cells ◽  
Adverse Effects ◽  
Autoimmune Diseases ◽  
Cellular Therapies ◽  
Tolerogenic Dendritic Cells ◽  
Life Threatening

Anti-myeloperoxidase vasculitis (MPO-AAV) is a life-threatening autoimmune disease which causes severe inflammation of small blood vessels, mainly in the kidney. As for many other autoimmune diseases, current treatments, which consist of general immunosuppressants, are partially effective, toxic and broadly immunosuppressive, causing significant and serious adverse effects in many patients. Therefore, there is an urgent need for more targeted and less harmful therapies. Tolerogenic dendritic cells, regulatory T cells and stem cells have emerged as attractive, new and safer options for the treatment for various autoimmune diseases due to their unique and selective immunosuppressive capacity. In this review, we will discuss how these cellular therapies offer potential to become novel and safer treatments for MPO-AAV.

scholarly journals Co-delivery of allergen epitope fragments and R848 inhibits food allergy by inducing tolerogenic dendritic cells and regulatory T cells

2019 ◽  
Vol Volume 14 ◽  
pp. 7053-7064 ◽  
Author(s):  
Jingyi Hong ◽  
Xiaojun Xiao ◽  
Qichan Gao ◽  
Shanshan Li ◽  
Bei Jiang ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Food Allergy ◽  
Regulatory T Cells ◽  
Tolerogenic Dendritic Cells
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