Tolerogenic dendritic cells suppress murine corneal allograft rejection by modulating CD28/CTLA-4 expression on regulatory T cells

2014 ◽  
Vol 38 (7) ◽  
pp. 835-848 ◽  
Author(s):  
Feng Yan ◽  
Li Cai ◽  
Yannian Hui ◽  
Suihua chen ◽  
Hao Meng ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Corneal Allograft ◽  
Tolerogenic Dendritic Cells ◽  
Corneal Allograft Rejection

scholarly journals The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Shang Li ◽  
Jing Yu ◽  
Chungang Guo ◽  
Ying Jie ◽  
Zhiqiang Pan
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Aqueous Humor ◽  
Allograft Rejection ◽  
Corneal Transplantation ◽  
Allograft Survival ◽  
Survival Group ◽  
Corneal Allograft ◽  
Group 3 ◽  
Corneal Allograft Rejection

Purpose. CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs). The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. Methods. A total of 65 mice received orthotopic penetrating transplantation. According to the survival scores of the grafts, the mice were divided into the rejection group and the survival group 3 weeks after transplantation. Th1, Th2, Th17, and regulatory T cells in the ipsilateral drainage lymph nodes and spleens were measured with flow cytometry. The related cytokines in aqueous humor were also analyzed. Results. The frequencies of Foxp3+Tregs, GARP+Tregs, and LAP+Tregs in the survival group were significantly higher than those in the rejection group. And the expression trend of CD4+LAP+ T cells and CD4+GARP+ T cells was consistent. The level of IFN-γ, TNF, IL-6, and IL-17A markedly increased in aqueous humor during corneal allograft rejection. The ratio of Th1/Th2 and Th17/LAP+Tregs significantly increased in the rejection group at the 3rd week after corneal transplantation. Conclusion. LAP+Tregs might be regarded as substitute for Foxp3+Tregs. The balance of Th1/Th2 and LAP+Tregs/Th17 is crucial for corneal allograft survival.

In vitro-expanded CD4+CD25highFoxp3+ regulatory T cells controls corneal allograft rejection

2012 ◽  
Vol 73 (11) ◽  
pp. 1061-1067 ◽  
Author(s):  
Xuming Guo ◽  
Ying Jie ◽  
Dong Ren ◽  
Hui Zeng ◽  
Yingnan Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Allograft Rejection ◽  
Corneal Allograft ◽  
Corneal Allograft Rejection

scholarly journals Co-delivery of allergen epitope fragments and R848 inhibits food allergy by inducing tolerogenic dendritic cells and regulatory T cells

2019 ◽  
Vol Volume 14 ◽  
pp. 7053-7064 ◽  
Author(s):  
Jingyi Hong ◽  
Xiaojun Xiao ◽  
Qichan Gao ◽  
Shanshan Li ◽  
Bei Jiang ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Food Allergy ◽  
Regulatory T Cells ◽  
Tolerogenic Dendritic Cells
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