d ‐Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells

2021 ◽  
Author(s):  
Long Lv ◽  
Nan Yang ◽  
Youhong Cao ◽  
Junqiang Dang ◽  
Likun Cheng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Signaling Pathway ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Ags Cells ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells

2013 ◽  
Vol 59 ◽  
pp. 703-708 ◽  
Author(s):  
Mei-Ying Xu ◽  
Dong Hwa Lee ◽  
Eun Ji Joo ◽  
Kun Ho Son ◽  
Yeong Shik Kim
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer

2011 ◽  
Vol 11 (2) ◽  
pp. 277-287 ◽  
Author(s):  
Jing Chen ◽  
Jieqiong Wang ◽  
Lei Lin ◽  
Lijun He ◽  
Yuanyuan Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Human Gastric Cancer ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells

2015 ◽  
Vol 47 (2) ◽  
pp. 563-572 ◽  
Author(s):  
PYOUNG RAK CHOI ◽  
YONG JUNG KANG ◽  
BOKYUNG SUNG ◽  
JAE HYUN KIM ◽  
HYUNG RYONG MOON ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells

2017 ◽  
Vol 37 (6) ◽  
pp. 3459-3466 ◽  
Author(s):  
Wei Li ◽  
Ying Zhou ◽  
Jin Yang ◽  
Haining Li ◽  
Huanhuan Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

STAM2 knockdown inhibits proliferation, migration, and invasion by affecting the JAK2/STAT3 signaling pathway in gastric cancer

2021 ◽  
Author(s):  
Yang Yang ◽  
Q i Zhang ◽  
Jiakui Liang ◽  
Meiyuan Yang ◽  
Zheng Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Mammalian Cells ◽  
Migration And Invasion ◽  
Boyden Chamber ◽  
Pathway Enrichment Analysis ◽  
Stat3 Signaling ◽  
Advanced Tumor ◽  
Stat3 Signaling Pathway ◽  
Tumor Node Metastasis Stage

Abstract Signal transducing adaptor molecule 2 (STAM2) is a phosphotyrosine protein, which regulates receptor signaling and trafficking of mammalian cells. However, its role in gastric cancer (GC) remains undiscovered. In this study, we aimed to investigate the functions of STAM2 in GC. The mRNA and protein expression levels of STAM2 were measured by quantitative real-time PCR, western blot analysis, and immunohistochemistry. STAM2 was stably silenced in AGS and HGC-27 cells using small interfering RNA. The function of STAM2 in GC cells was further investigated by CCK-8 assay, EdU incorporation assay, flow cytometry, and scratch wound healing and Boyden chamber assays. Additionally, we conducted biological pathway enrichment analysis and rescue assays to explore the effects of STAM2 on JAK/STAT signaling pathway. Our results showed that STAM2 is remarkably highly expressed in GC tissues and cells, and overexpressed STAM2 is correlated with tumor size, advanced tumor node metastasis stage, and poor prognosis. In addition, STAM2 knockdown could significantly inhibit proliferation, block cell cycle, and restrain migration and invasion capabilities of GC cells. Mechanistically, we found that STAM2 knockdown effectively decreased the expressions of MMP2 and MMP9 and the phosphorylation levels of JAK2 and STAT3. Taken together, this study revealed that STAM2 knockdown could suppress malignant process by targeting the JAK2/STAT3 signaling pathway in GC.

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