scholarly journals Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells

2017 ◽  
Vol 37 (6) ◽  
pp. 3459-3466 ◽  
Author(s):  
Wei Li ◽  
Ying Zhou ◽  
Jin Yang ◽  
Haining Li ◽  
Huanhuan Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells

2013 ◽  
Vol 59 ◽  
pp. 703-708 ◽  
Author(s):  
Mei-Ying Xu ◽  
Dong Hwa Lee ◽  
Eun Ji Joo ◽  
Kun Ho Son ◽  
Yeong Shik Kim
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals MHY218-induced apoptotic cell death is enhanced by the inhibition of autophagy in AGS human gastric cancer cells

2015 ◽  
Vol 47 (2) ◽  
pp. 563-572 ◽  
Author(s):  
PYOUNG RAK CHOI ◽  
YONG JUNG KANG ◽  
BOKYUNG SUNG ◽  
JAE HYUN KIM ◽  
HYUNG RYONG MOON ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Protein kinase Cα promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage

Oncogene ◽  
1999 ◽  
Vol 18 (40) ◽  
pp. 5604-5609 ◽  
Author(s):  
Hiroyuki Okuda ◽  
Masaaki Adachi ◽  
Masaaki Miyazawa ◽  
Yuji Hinoda ◽  
Kohzoh Imai
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Gastric Cancer Cells ◽  
Protein Kinase Cα

scholarly journals Silencing of acetyl-CoA carboxylase-α gene in human gastric cancer cells inhibits proliferation via induction of apoptosis, autophagy and suppression of cell invasion

2021 ◽  
Vol 18 (10) ◽  
pp. 2025-2030
Author(s):  
Chunsong Yu ◽  
Xuehong Wu ◽  
Bihua Yao ◽  
Huaxing Tao
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Annexin V ◽  
Migration And Invasion ◽  
Human Gastric Cancer ◽  
Acetyl Coa Carboxylase ◽  
Gastric Cancer Cells ◽  
Acetyl Coa

Purpose: To study the role and therapeutic potential of acetyl-CoA-carboxylase-α (ACC) in the management of gastric cancer. Methods: Expression of ACC in gastric cancer cell lines was determined using quantitative real-time polymerase chain reaction (qRT-PCR). Lipofectamine 2000 reagent was used for transfection, while cell viability was determined by MTT assay. Apoptotic cell death was assayed with 4′, 6-diamidino-2- phenylindole (DAPI) and acridine orange/ethidium bromide (AO/EB) staining. The proportion of apoptotic cells was estimated with Annexin V/PI staining. Wound healing and Transwell assays were employed to monitor cell migration and invasion, while protein expression was determined using western blotting. Results: The results showed that ACC was significantly enhanced in SNU-1 gastric cancer cells (4.2- fold). Silencing of ACC in SNU-1 gastric cancer cells caused significant decrease in cell proliferation (p < 0.05). Electron microscopy examination showed that ACC silencing triggered autophagic cell death in SNU-1 cells, and increased expression of LC3 II. Results from DAPI and AO/EB assays demonstrated that ACC silencing also promoted apoptosis in SNU-1 gastric cancer cells. Annexin V/PI assay results revealed that apoptotic cell population increased from 2.7 to 13.8 % due to ACC silencing (p < 0.05). Moreover, Bax expression increased, while Bcl-2 expression decreased upon ACC silencing. Transwell assay results indicate that ACC silencing caused marked decrease in the invasion of the SNU-1 cells and downregulation of the expressions of MMP-2 and MMP-9 (p < 0.05). Conclusion: ACC is likely to be an important therapeutic target for gastric cancer.

Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death

2004 ◽  
Vol 32 (3) ◽  
pp. 274-285 ◽  
Author(s):  
Christof Seidl ◽  
Hedwig Schr�ck ◽  
Sabine Seidenschwang ◽  
Roswitha Beck ◽  
Ernst Schmid ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Gastric Cancer Cells
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