Surface modifications affect iron oxide nanoparticles' biodistribution after multiple‐dose administration in rats

2020 ◽  
Author(s):  
Heba M. Fahmy ◽  
Taiseer M. Abd El‐Daim ◽  
Omnia A. Ali ◽  
Asmaa A. Hassan ◽  
Faten F. Mohammed ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Multiple Dose ◽  
Surface Modifications ◽  
Oxide Nanoparticles ◽  
Dose Administration ◽  
Multiple Dose Administration

Subcellular distributions of iron oxide nanoparticles in rat brains affected by different surface modifications

2019 ◽  
Vol 107 (9) ◽  
pp. 1988-1998 ◽  
Author(s):  
Sheng Wang ◽  
Baolin Zhang ◽  
Lichao Su ◽  
Wan Nie ◽  
Dong Han ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Modifications ◽  
Oxide Nanoparticles

Correlation between physicochemical properties of superparamagnetic iron oxide nanoparticles and their reactivity with hydrogen peroxide

2020 ◽  
Vol 98 (10) ◽  
pp. 601-608
Author(s):  
Taraneh Javanbakht ◽  
Sophie Laurent ◽  
Dimitri Stanicki ◽  
Mathieu Frenette
Keyword(s):  
Hydrogen Peroxide ◽  
Iron Oxide ◽  
Physicochemical Properties ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Surface Modifications ◽  
Oxide Nanoparticles ◽  
Amine Groups ◽  
The Comparative Study ◽  
Positively Charged

The present study focuses on the effects of the physicochemical properties of superparamagnetic PEG-modified, positively charged, and negatively charged iron oxide nanoparticles (SPIONs) on their reactivity with hydrogen peroxide. Our hypothesis was that the reactivity of SPIONs in this reaction would depend on their surface properties. The comparative study of the nanoparticles with DLS and TEM revealed the average sizes of PEG-modified, positively charged, and negatively charged SPIONs. We observed that the reactivity of negatively charged SPIONs with hydrogen peroxide was less than that of positively charged SPIONs and that of these second nanoparticles was less than that of PEG-modified SPIONs. This difference in the reactivity of these SPIONs with hydrogen peroxide was attributed to the presence of carboxyl or amine groups on their surface. However, the values of the rate constants of the reactions of PEG-modified, positively charged, and negatively charged SPIONs with hydrogen peroxide showed that the reaction of negatively charged SPIONs with hydrogen peroxide was more rapid than that of PEG-modified SPIONs and the reaction of these second SPIONs with hydrogen peroxide was more rapid than that of positively charged SPIONs. The surface study of the SPIONs using XPS showed that the high-resolution spectra of these nanoparticles changed after reaction with hydrogen peroxide, which indicates their surface modifications. These investigations can help develop more appropriate nanoparticles with controlled physicochemical properties.

scholarly journals Multifunctional magnetic iron oxide nanoparticles: diverse synthetic approaches, surface modifications, cytotoxicity towards biomedical and industrial applications

BMC Materials ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Subramanian Natarajan ◽  
Kannan Harini ◽  
Gnana Prakash Gajula ◽  
Bruno Sarmento ◽  
Maria Teresa Neves-Petersen ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Modifications ◽  
Synthetic Methods ◽  
Biomedical Science ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Cytotoxic Effects ◽  
Magnetic Iron Oxide

AbstractMagnetic iron oxide nanoparticles (MIONPs) play a major role in the emerging fields of nanotechnology to facilitate rapid advancements in biomedical and industrial platforms. The superparamagnetic properties of MIONPs and their environment friendly synthetic methods with well-defined particle size have become indispensable to obtain their full potential in a variety of applications ranging from cellular to diverse areas of biomedical science. Thus, the broadened scope and need for MIONPs in their demanding fields of applications required to be highlighted for a comprehensive understanding of their state-of-the-art. Many synthetic methods, however, do not entirely abolish their undesired cytotoxic effects caused by free radical production and high iron dosage. In addition, the agglomeration of MIONPs has also been a major problem. To alleviate these issues, suitable surface modification strategies adaptive to MIONPs has been suggested not only for the effective cytotoxicity control but also to minimize their agglomeration. The surface modification using inorganic and organic polymeric materials would represent an efficient strategy to utilize the diagnostic and therapeutic potentials of MIONPs in various human diseases including cancer. This review article elaborates the structural and magnetic properties of MIONPs, specifically magnetite, maghemite and hematite, followed by the important synthetic methods that can be exploited for biomedical approaches. The in vivo cytotoxic effects and the possible surface modifications employed to eliminate the cytotoxicity thereby enhancing the nanoparticle efficacy are also critically discussed. The roles and applications of surface modified MIONPs in medical and industrial platforms have been described for the benefits of global well-being.

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