Antilipoperoxidative and antioxidant effects of S-allyl cysteine sulfoxide on isoproterenol-induced myocardial infarction in wistar rats

2006 ◽  
Vol 20 (4) ◽  
pp. 167-173 ◽  
Author(s):  
T. Sangeetha ◽  
S. Darlin Quine
Keyword(s):  
Myocardial Infarction ◽  
Wistar Rats ◽  
Antioxidant Effects ◽  
Cysteine Sulfoxide

scholarly journals Differences in the expression of the renin angiotensin system and the kallikrein-kinin system during the course of myocardial infarction in male and female Wistar rats

2020 ◽  
Vol 21 (2) ◽  
pp. 147032031990003
Author(s):  
Jazmín Flores-Monroy ◽  
Diego Lezama-Martínez ◽  
Salvador Fonseca-Coronado ◽  
Luisa Martínez-Aguilar
Keyword(s):  
Myocardial Infarction ◽  
Angiotensin Converting Enzyme ◽  
Wistar Rats ◽  
Renin Angiotensin System ◽  
Converting Enzyme ◽  
Kinin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Female Wistar Rats ◽  
Kallikrein Kinin System

Background: There is some evidence that components of the renin-angiotensin system and kallikrein-kinin system are not similarly regulated in both sexes. The aim of this work was to analyze the expression of angiotensin-converting enzyme, angiotensin-converting enzyme 2, angiotensin 1 receptor, angiotensin 2 receptor, beta-1 receptor, and beta-2 receptor during the evolution of myocardial infarction. Methods: Thirty-six male and 36 female Wistar rats were used. Myocardial infarction was induced. Six groups of both sexes were formed, ( n=6): (a) sham; (b) 48 h myocardial infarction; (c) one week myocardial infarction; (d) two weeks myocardial infarction; (e) three weeks myocardial infarction and (f) four weeks myocardial infarction. The expression was evaluated by real-time polymerase chain reaction on the penumbra of left ventricle. Results: The mRNA expression of most biomarkers was lower in females than in males. During acute infarction, an increase of all protein expression was found in female and at two weeks while in the male only biomarker changes occurred at three weeks. In addition, in male biomarkers mRNA expression decreased during chronic infarction while in females it did not. Conclusions: The renin-angiotensin system and kallikrein-kinin system biomarkers expression occurs at earlier times in the female than in the male rat. In addition, during chronic myocardial infarction these biomarkers remained unchanged in females while in males they decreased.

Cardioprotective effect of ‘Marutham’ a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats

Fitoterapia ◽  
2008 ◽  
Vol 79 (6) ◽  
pp. 433-438 ◽  
Author(s):  
Ponnian Stanely Mainzen Prince ◽  
Selvaraju Suman ◽  
Periyathambi Thangappan Devika ◽  
Muthukumarasamy Vaithianathan
Keyword(s):  
Myocardial Infarction ◽  
Wistar Rats ◽  
Cardioprotective Effect ◽  
Polyherbal Formulation

scholarly journals Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats

Redox Report ◽  
2012 ◽  
Vol 17 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Khalid S. Al Numair ◽  
Govindasamy Chandramohan ◽  
Mohammed A. Alsaif ◽  
Arul Albert Baskar
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Mitochondrial Function ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet

2019 ◽  
Vol 56 (2) ◽  
pp. 337-340
Author(s):  
Daniela Miricescu ◽  
Daniela Gabriela Balan ◽  
Catalina Radulescu ◽  
Radu Radulescu ◽  
Iulia-Ioana Stanescu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Drug Delivery Systems ◽  
Wistar Rats ◽  
Male Rats ◽  
Control Group ◽  
Daily Dose ◽  
Hypercaloric Diet ◽  
Antioxidant Effects ◽  
Wistar Male Rats ◽  
Biomarkers Of Oxidative Stress

PLGA (Poli-lactic-co-glycolic acid) nanoparticles (NPs) are curently used as drug delivery systems for many types of drugs including antioxidants such as vitamin E. The main aim of our study was to test the antioxidant effects of PLGA-vitamin E on Wistar male rats. Two groups of Wistar rats received a hypercaloric diet for 21 days: the first group received besides the hypercaloric diet a daily dose of PLGA loaded with vitamin E and the control group received only the hypercaloric diet. Spleen cellular lysate has been used to detect biomarkers of oxidative stress such as malondialdehyde, glutathione, advanced human oxidative protein and vitamin E. After 3 weeks of treatment, statistical significant changes have been detected between the two groups.

scholarly journals Features of cellular and molecular inflammatory mechanisms involvement in hormone-mediated myocardial experimental injury

2013 ◽  
Vol 94 (5) ◽  
pp. 723-726
Author(s):  
N N Mayanskaya ◽  
L D Hidirova ◽  
S D Mayanskaya
Keyword(s):  
Myocardial Infarction ◽  
Lipid Peroxidation ◽  
Tumor Necrosis ◽  
Wistar Rats ◽  
Biocidal Activity ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Tetrazolium Test ◽  
Pro Inflammatory Cytokines

Aim. To study the features of inflammatory effector mechanisms variation in Wistar rats with metabolic non-coronary myocardial infarction. Methods. Metabolic myocardial infarction was reproduced in Wistar rats by adrenalin injection. Metabolic myocardial infarction was verified by electrocardiography and histological examination. Biocidal activity of blood neutrophils was determined by nitro blue tetrazolium test and chemiluminescence, cytokine serum levels (interleukin-1β, interleukin 6 and tumor necrosis factor alpha) were determined by ELISA. Lipid peroxidation was assessed by measuring malondialdehyde, diene conjugates and diketones blood concentrations. Catalase activity and reduced glutathione level were determined in erythrocyte hemolysate, serum activity of superoxide dismutase was also measured. Intact animals were examined as a control group. Results. In rats with metabolic myocardial infarction, oxygen-dependent leukocyte biocidity (determined by nitro blue tetrazolium test and chemiluminescence) increased dramatically from the first day of the adrenalin administration and continued to increase until the end of the experiment (day 14). Accordingly, the production of active oxygen metabolites, which intensified the lipid peroxidation, was increasing. Simultaneously an imbalance between pro-and antioxidant system parameters was detected. Serum concentration of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1β, interleukin-6) increased. Conclusion. Long-term administration of adrenalin to experimental animals causes an increase in the neutrophils biocidal activity, accompanied by release of reactive oxygen species, pro-inflammatory cytokines, lipid peroxidation intensifying and decreased compensation by antioxidant defense system, which together can be a powerful trigger of myocardial damage.

scholarly journals Cardio Protective Action of Cilostazol, Milrinone and Their Combination over Isoproterenol Induced Myocardial Infarction in Wistar Rats

2017 ◽  
Vol 5 (1) ◽  
pp. 8-14
Author(s):  
Prashant Kumar Dhakad ◽  
Pramod Kumar Sharma ◽  
Sokindra Kumar ◽  
Ashish Kr. Sharma ◽  
Raghav Mishra ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wistar Rats ◽  
Protective Action
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