Comparison between modifications of lens proteins resulted from glycation with methylglyoxal, glyoxal, ascorbic acid, and fructose

2002 ◽  
Vol 16 (3) ◽  
pp. 140-145 ◽  
Author(s):  
Mariana Argirova ◽  
Winrich Breipohl
Keyword(s):  
Ascorbic Acid ◽  
Lens Proteins

scholarly journals Reaction of tyrosine oxidation products with proteins of the lens

1968 ◽  
Vol 109 (2) ◽  
pp. 301-305 ◽  
Author(s):  
Antoinette Pirie
Keyword(s):  
Ascorbic Acid ◽  
Fluorescence Spectra ◽  
Ferrous Sulphate ◽  
Oxidation Products ◽  
Thiol Groups ◽  
Lens Proteins ◽  
Bovine Lens ◽  
Tyrosine Oxidation ◽  
Cataractous Lens

Oxidation of tyrosine in the presence of bovine lens proteins leads to the formation of brown or black melanoproteins. Both tyrosinase and the oxidizing system of ferrous sulphate–ascorbic acid–EDTA are effective. The fluorescence of the lens proteins is both altered and enhanced by the tyrosine-oxidizing systems. Their fluorescence spectra resemble those of urea-insoluble proteins of human cataractous lens and of 1,2-naphthaquinone–proteins of naphthalene cataract. The lens proteins lose their thiol groups and, in acid hydrolysates of treated β-and γ-crystallins, a substance has been detected chromatographically that behaves similarly to a compound formed when 3,4-dihydroxyphenylalanine (dopa) is oxidized by tyrosinase in the presence of cysteine. Analysis and behaviour of this substance from hydrolysates of lens proteins suggest that it is a compound of cysteine and dopa.

The extent of Nϵ-(carboxymethyl)lysine formation in lens proteins and polylysine by the autoxidation products of ascorbic acid

1992 ◽  
Vol 1117 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Simon H. Slight ◽  
Malladi Prabhakaram ◽  
Dong Bum Shin ◽  
Milton S. Feather ◽  
Beryl J. Ortwerth
Keyword(s):  
Ascorbic Acid ◽  
Lens Proteins ◽  
Carboxymethyl Lysine

scholarly journals Glycation by ascorbic acid oxidation products leads to the aggregation of lens proteins

2008 ◽  
Vol 1782 (1) ◽  
pp. 22-34 ◽  
Author(s):  
Mikhail Linetsky ◽  
Ekaterina Shipova ◽  
Rongzhu Cheng ◽  
Beryl J. Ortwerth
Keyword(s):  
Ascorbic Acid ◽  
Oxidation Products ◽  
Acid Oxidation ◽  
Lens Proteins

ASCORBIC ACID GLYCATION OF LENS PROTEINS PRODUCES UVA SENSITIZERS SIMILAR TO THOSE IN HUMAN LENS

1995 ◽  
Vol 62 (3) ◽  
pp. 454-462 ◽  
Author(s):  
B. J. Ortwerth ◽  
Mikhail Linetsky ◽  
Paul R. Olesen
Keyword(s):  
Ascorbic Acid ◽  
Human Lens ◽  
Lens Proteins
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