scholarly journals Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS

2011 ◽  
Vol 26 (8) ◽  
pp. 1802-1807 ◽  
Author(s):  
M Kassim Javaid ◽  
Daniel Prieto-Alhambra ◽  
Li-Yung Lui ◽  
Peggy Cawthon ◽  
Nigel K Arden ◽  
...  
Keyword(s):  
Volumetric Bmd ◽  
Femoral Size

scholarly journals Anatomical variation of the distal femur - a CT data analysis of 24,042 knees

2018 ◽  
Vol 6 (4_suppl2) ◽  
pp. 2325967118S0003
Author(s):  
Cornelia Merz ◽  
Andre Steinert ◽  
Wiliam Kurtz ◽  
Franz Xaver Köck ◽  
Johannes Beckmann
Keyword(s):  
Distal Femur ◽  
External Rotation ◽  
Anatomical Variation ◽  
Data Sets ◽  
Medial Condyle ◽  
First Results ◽  
The Difference ◽  
Ct Data ◽  
The Individual ◽  
Femoral Size

Based on a large quantity of CT data, variations in distal femoral geometry was examined and evaluated for TKA. A retrospective study was performed on 24,042 data sets generated during the process of designing individual knee implants. Following parameters were recorded for the distal femur: Femoral absolute anterior-posterior (AP) and medial-lateral (ML) extent, lateral and medial condyle and trochlea size, distal condylar offset (DCO) between lateral and medial condyle, and the difference between medial and lateral posterior condylar offset (PCO) measured in AP direction. Variable patient geometry was found with analysis of the AP and ML extent. Approximately one-third of the patients would experience size conflicts of +/- 3 mm with standard arthroplasty systems. 62% of the knees had a DCO> 1 mm. 83% of the distal femur had a mediolateral difference in PCO> 2 mm, which corresponds to about 3° external rotation and does not correlate with the femoral size. There is a distinct variability of femoral AP and ML extent as well as offsets / asymmetries. Medial and lateral PCOs are different and do not correlate with femoral size. This first results in mismatches between size of implant and individual knee anatomy and secondly in possible softtissue release and different femoral external rotations to adapt systems with fixed distal geometry to the individual situation.

scholarly journals High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men

2009 ◽  
Vol 24 (12) ◽  
pp. 2039-2049 ◽  
Author(s):  
Laura M Yerges ◽  
Lambertus Klei ◽  
Jane A Cauley ◽  
Kathryn Roeder ◽  
Candace M Kammerer ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Association Study ◽  
Candidate Genes ◽  
Older Men ◽  
High Density ◽  
Volumetric Bmd

scholarly journals Effects of Genes, Sex, Age, and Activity on BMC, Bone Size, and Areal and Volumetric BMD

2007 ◽  
Vol 22 (5) ◽  
pp. 737-746 ◽  
Author(s):  
Lorena M Havill ◽  
Michael C Mahaney ◽  
Teresa L Binkley ◽  
Bonny L Specker
Keyword(s):  
Bone Size ◽  
Volumetric Bmd

scholarly journals Bone Density, Turnover, and Estimated Strength in Postmenopausal Women Treated With Odanacatib: A Randomized Trial

2013 ◽  
Vol 98 (2) ◽  
pp. 571-580 ◽  
Author(s):  
Kim Brixen ◽  
Roland Chapurlat ◽  
Angela M. Cheung ◽  
Tony M. Keaveny ◽  
Thomas Fuerst ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Resorption ◽  
Bone Formation ◽  
Postmenopausal Women ◽  
Bone Strength ◽  
Bone Mineral ◽  
Bone Resorption Marker ◽  
Mineral Density ◽  
Volumetric Bmd ◽  
The Impact

Abstract Context: Odanacatib, a cathepsin K inhibitor, increases spine and hip areal bone mineral density (BMD) in postmenopausal women with low BMD and cortical thickness in ovariectomized monkeys. Objective: The objective of the study was to examine the impact of odanacatib on the trabecular and cortical bone compartments and estimated strength at the hip and spine. Design: This was a randomized, double-blind, 2-year trial. Setting: The study was conducted at a private or institutional practice. Participants: Participants included 214 postmenopausal women with low areal BMD. Intervention: The intervention included odanacatib 50 mg or placebo weekly. Main Outcome Measures: Changes in areal BMD by dual-energy x-ray absorptiometry (primary end point, 1 year areal BMD change at lumbar spine), bone turnover markers, volumetric BMD by quantitative computed tomography (QCT), and bone strength estimated by finite element analysis were measured. Results: Year 1 lumbar spine areal BMD percent change from baseline was 3.5% greater with odanacatib than placebo (P < .001). Bone-resorption marker C-telopeptide of type 1 collagen was significantly lower with odanacatib vs placebo at 6 months and 2 years (P < .001). Bone-formation marker procollagen I N-terminal peptide initially decreased with odanacatib but by 2 years did not differ from placebo. After 6 months, odanacatib-treated women had greater increases in trabecular volumetric BMD and estimated compressive strength at the spine and integral and trabecular volumetric BMD and estimated strength at the hip (P < .001). At the cortical envelope of the femoral neck, bone mineral content, thickness, volume, and cross-sectional area also increased from baseline with odanacatib vs placebo (P < .001 at 24 months). Adverse experiences were similar between groups. Conclusions: Over 2 years, odanacatib decreased bone resorption, maintained bone formation, increased areal and volumetric BMD, and increased estimated bone strength at both the hip and spine.

Iliac trabecular volumetric bmd at organ and tissue levels: relationships with microstruscture and DXA measures

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S65
Author(s):  
Yebin Jiang ◽  
Er-Yuan Liao ◽  
Xian-Ping Wu ◽  
Ru-Chun Dai
Keyword(s):  
Tissue Levels ◽  
Volumetric Bmd

scholarly journals Bone Structure and Volumetric BMD in Overweight Children: A Longitudinal Study

2008 ◽  
Vol 23 (12) ◽  
pp. 1946-1953 ◽  
Author(s):  
Rachel J Wetzsteon ◽  
Moira A Petit ◽  
Heather M Macdonald ◽  
Julie M Hughes ◽  
Thomas J Beck ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Bone Structure ◽  
Overweight Children ◽  
Volumetric Bmd

Low volumetric BMD is linked to upper-limb fracture in pubertal girls and persists into adulthood: A seven-year cohort study

Bone ◽  
2009 ◽  
Vol 45 (3) ◽  
pp. 480-486 ◽  
Author(s):  
Sulin Cheng ◽  
Leiting Xu ◽  
Patrick H.F. Nicholson ◽  
Frances Tylavsky ◽  
Arja Lyytikäinen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Upper Limb ◽  
Limb Fracture ◽  
Volumetric Bmd ◽  
Upper Limb Fracture

scholarly journals Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression ofSLC1A3andEPHB2

2016 ◽  
Vol 31 (12) ◽  
pp. 2085-2097 ◽  
Author(s):  
Carrie M Nielson ◽  
Ching-Ti Liu ◽  
Albert V Smith ◽  
Cheryl L Ackert-Bicknell ◽  
Sjur Reppe ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Genetic Variants ◽  
Vertebral Fracture Risk ◽  
Volumetric Bmd

scholarly journals Hyperglycemia Is Not Associated With Higher Volumetric BMD in a Chinese Health Check-up Cohort

2022 ◽  
Vol 12 ◽  
Author(s):  
Ling Wang ◽  
Kaiping Zhao ◽  
Xiaojuan Zha ◽  
Limei Ran ◽  
Heng Su ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fracture Risk ◽  
Fat Mass ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Total Cohort ◽  
Volumetric Bmd

Background and PurposeType 2 diabetes mellitus patients have an increased fracture risk despite having higher areal bone mineral density (aBMD) measured by DXA. This apparent paradox might be explained by the overestimation of BMD by DXA due to the higher fat mass in type 2 diabetes mellitus patients. Volumetric BMD (vBMD) as assessed by quantitative CT (QCT) is not influenced by fat mass. We assessed the association of vBMD and fasting plasma glucose in a large cohort of Chinese subjects and compared the vBMD in healthy and diabetic subjects. In addition, we compared the relation between aBMD, vBMD, glucose and fat mass in a subset of this cohort.Materials and Methods10309 participants from the China Biobank project underwent QCT based on chest low dose CT to compute vBMD of L1 and L2 vertebrae and FPG measurements between 2018 and 2019. Among them, 1037 subjects also had spine DXA scans. Data was analyzed using linear regression models.ResultsIn the total cohort (5889 men and 4420 women, mean age 53 years, range 30-96), there was no significant association between vBMD and FPG after adjustment for age (women: p=0.774; men: p=0.149). 291 women and 606 men fitted the diagnostic criteria of diabetes. Both women and men with diabetes had lower vBMD compared to non-diabetic subjects, but this became non-significant after adjusting for age in the total cohort (women: p=0.817; men: p=0.288) and after propensity score matching based on age (women: p=0.678; men: p=0.135). In the DXA subcohort, aBMD was significantly higher in men with diabetes after adjusting for age and this difference disappeared after further adjusting for total fat area (p=0.064).ConclusionWe did not find any effect of fasting plasma glucose or diabetes on the volumetric BMD measured with QCT after adjustment for age. Therefore, vBMD measured with QCT might be a more reliable measurement to diagnose osteoporosis and assess fracture risk than aBMD measured with DXA in diabetic patients.

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