Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

Richard Eastell; Shinichi Nagase; Michiyo Ohyama; Maria Small; James Sawyer; Steven Boonen; Tim Spector; Tomohiro Kuwayama; Steve Deacon

doi:10.1002/jbmr.341

Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

Journal of Bone and Mineral Research ◽

10.1002/jbmr.341 ◽

2011 ◽

Vol 26 (6) ◽

pp. 1303-1312 ◽

Cited By ~ 91

Author(s):

Richard Eastell ◽

Shinichi Nagase ◽

Michiyo Ohyama ◽

Maria Small ◽

James Sawyer ◽

...

Keyword(s):

Postmenopausal Osteoporosis ◽

Cathepsin K ◽

Safety And Efficacy ◽

Cathepsin K Inhibitor ◽

Ocean Study

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The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study

Journal of Bone and Mineral Research ◽

10.1002/jbmr.2080 ◽

2014 ◽

Vol 29 (3) ◽

pp. 629-638 ◽

Cited By ~ 31

Author(s):

Klaus Engelke ◽

Shinichi Nagase ◽

Thomas Fuerst ◽

Maria Small ◽

Tomohiro Kuwayama ◽

...

Keyword(s):

Cortical Bone ◽

Postmenopausal Osteoporosis ◽

Cathepsin K ◽

Cathepsin K Inhibitor ◽

Ocean Study

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Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

BMC Musculoskeletal Disorders ◽

10.1186/s12891-017-1625-y ◽

2017 ◽

Vol 18 (1) ◽

Cited By ~ 5

Author(s):

Makoto Tanaka ◽

Yoshitaka Hashimoto ◽

Chihiro Hasegawa ◽

Steve Deacon ◽

Richard Eastell

Keyword(s):

Postmenopausal Osteoporosis ◽

Phase Ii ◽

Phase Ii Trial ◽

Cathepsin K ◽

Cathepsin K Inhibitor

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Safety and efficacy of six months' open label extension post-RCT using the novel cathepsin K inhibitor MIV-711 in patients with knee osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2019.02.564 ◽

2019 ◽

Vol 27 ◽

pp. S501-S502

Author(s):

P.G. Conaghan ◽

M.A. Bowes ◽

S.R. Kingsbury ◽

A. Brett ◽

G. Guillard ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Cathepsin K ◽

The Novel ◽

Open Label ◽

Safety And Efficacy ◽

Cathepsin K Inhibitor ◽

Open Label Extension

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Efficacy and safety of the cathepsin K inhibitor, ONO-5334, and alendronate on post-menopausal osteopenia or osteoporosis: 2-year results from the ocean study

Bone ◽

10.1016/j.bone.2011.03.131 ◽

2011 ◽

Vol 48 ◽

pp. S92-S93

Author(s):

R. Eastell ◽

S. Nagase ◽

S. Boonen ◽

T. Spector ◽

M. Small ◽

...

Keyword(s):

Cathepsin K ◽

Efficacy And Safety ◽

Cathepsin K Inhibitor ◽

Ocean Study ◽

Post Menopausal

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Faculty Opinions recommendation of Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized, Placebo-Controlled Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737143597.793573698 ◽

2020 ◽

Author(s):

Susanne Grässel

Keyword(s):

Cathepsin K ◽

Controlled Study ◽

Cathepsin K Inhibitor ◽

Disease Modifying

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112 EFFECT OF THE SELECTIVE CATHEPSIN K INHIBITOR, MIV-711, ON MARKERS OF CARTILAGE DEGRADATION AND ON GROSS AND HISTOPATHOLOGY SCORES IN DOGS SUBJECTED TO PARTIAL MEDIAL MENISCECTOMY, AN EXPERIMENTAL MODEL OF OSTEOARTHRITIS

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(11)60139-8 ◽

2011 ◽

Vol 19 ◽

pp. S59

Author(s):

E. Lindstrom ◽

L. Vrang ◽

S. Sedig ◽

Y. Terelius ◽

K. Wikström ◽

...

Keyword(s):

Experimental Model ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

Medial Meniscectomy

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Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis

Bone ◽

10.1016/j.bone.2012.02.598 ◽

2012 ◽

Vol 50 ◽

pp. S188-S189 ◽

Cited By ~ 1

Author(s):

E. Lindstrom⁎ ◽

L. Vrang ◽

S. Sedig ◽

Y. Terelius ◽

K. Wikström ◽

...

Keyword(s):

Bone Resorption ◽

Knee Joint ◽

Experimental Model ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

Joint Pathology ◽

Medial Meniscectomy ◽

And Cartilage

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Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.279 ◽

2014 ◽

Vol 54 (8) ◽

pp. 937-948 ◽

Cited By ~ 4

Author(s):

Chihiro Hasegawa ◽

Helen Kastrissios ◽

Jonathan Monteleone ◽

Tomoya Ohno ◽

Takeo Umemura ◽

...

Keyword(s):

Bone Mineral Density ◽

Modeling And Simulation ◽

Bone Mineral ◽

Cathepsin K ◽

Phase 2 ◽

Mineral Density ◽

Dose Selection ◽

Cathepsin K Inhibitor ◽

Phase 2 Study ◽

Density Response

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Letter: The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis

Endocrinology and Metabolism ◽

10.3803/enm.2012.27.1.105 ◽

2012 ◽

Vol 27 (1) ◽

pp. 105

Author(s):

Sang Ah Lee

Keyword(s):

Bone Mineral Density ◽

Animal Model ◽

Combination Therapy ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cathepsin K Inhibitor

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Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2009.03.015 ◽

2009 ◽

Vol 17 (9) ◽

pp. 1236-1243 ◽

Cited By ~ 42

Author(s):

J.R. Connor ◽

C. LePage ◽

B.A. Swift ◽

D. Yamashita ◽

A.M. Bendele ◽

...

Keyword(s):

Cathepsin K ◽

Protective Effects ◽

Cathepsin K Inhibitor ◽

Medial Meniscectomy

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