scholarly journals The Effect of the Cathepsin K Inhibitor ONO-5334 on Trabecular and Cortical Bone in Postmenopausal Osteoporosis: The OCEAN Study

2014 ◽  
Vol 29 (3) ◽  
pp. 629-638 ◽  
Author(s):  
Klaus Engelke ◽  
Shinichi Nagase ◽  
Thomas Fuerst ◽  
Maria Small ◽  
Tomohiro Kuwayama ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Postmenopausal Osteoporosis ◽  
Cathepsin K ◽  
Cathepsin K Inhibitor ◽  
Ocean Study

scholarly journals Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study

2011 ◽  
Vol 26 (6) ◽  
pp. 1303-1312 ◽  
Author(s):  
Richard Eastell ◽  
Shinichi Nagase ◽  
Michiyo Ohyama ◽  
Maria Small ◽  
James Sawyer ◽  
...  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Cathepsin K ◽  
Safety And Efficacy ◽  
Cathepsin K Inhibitor ◽  
Ocean Study

ONO-5334, a cathepsin K inhibitor, improves bone strength by preferentially increasing cortical bone mass in ovariectomized rats

2013 ◽  
Vol 32 (6) ◽  
pp. 645-652 ◽  
Author(s):  
Yasuo Ochi ◽  
Hiroyuki Yamada ◽  
Hiroshi Mori ◽  
Naoki Kawada ◽  
Ryoji Kayasuga ◽  
...  
Keyword(s):  
Bone Mass ◽  
Cortical Bone ◽  
Bone Strength ◽  
Cathepsin K ◽  
Ovariectomized Rats ◽  
Cathepsin K Inhibitor ◽  
Cortical Bone Mass

Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice

Bone ◽  
2007 ◽  
Vol 40 (5) ◽  
pp. 1231-1237 ◽  
Author(s):  
Anbo Xiang ◽  
Masahiro Kanematsu ◽  
Sanjay Kumar ◽  
Dennis Yamashita ◽  
Toshihiko Kaise ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Formation ◽  
Cortical Bone ◽  
Cathepsin K ◽  
Micro Ct ◽  
Bone Parameters ◽  
Cathepsin K Inhibitor ◽  
Ovariectomized Mice
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