Advances in electrospun scaffolds for meniscus tissue engineering and regeneration

Author(s):  
Xiaoyu Wang ◽  
Yangfan Ding ◽  
Haiyan Li ◽  
Xiumei Mo ◽  
Jinglei Wu
Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1444 ◽  
Author(s):  
Sun Hee Cho ◽  
Jeong In Kim ◽  
Cheol Sang Kim ◽  
Chan Hee Park ◽  
In Gi Kim

To date, many researchers have studied a considerable number of three-dimensional (3D) cotton-like electrospun scaffolds for tissue engineering, including the generation of bone, cartilage, and skin tissue. Although numerous 3D electrospun fibrous matrixes have been successfully developed, additional research is needed to produce 3D patterned and sophisticated structures. The development of 3D fibrous matrixes with patterned and sophisticated structures (FM-PSS) capable of mimicking the extracellular matrix (ECM) is important for advancing tissue engineering. Because modulating nano to microscale features of the 3D fibrous scaffold to control the ambient microenvironment of target tissue cells can play a pivotal role in inducing tissue morphogenesis after transplantation in a living system. To achieve this objective, the 3D FM-PSSs were successfully generated by the electrospinning using a directional change of the sharply inclined array collector. The 3D FM-PSSs overcome the current limitations of conventional electrospun cotton-type 3D matrixes of random fibers.


2013 ◽  
Vol 830 ◽  
pp. 490-494
Author(s):  
Zhi Ping Wang

With the development of tissue engineering and materials science, through the research of meniscus tissue engineering to discover novel tissue engineering materials, and further accelerate the research of meniscus tissue engineering, through clinical trials and application of finding appropriate meniscus substitute, which can provide a new mode of treatment for meniscus repair. The focus of the current study including the mechanism of meniscus injury can absorb the natural collagen meniscus tissue engineering scaffolds as feasibility analysis, stress stimulation, meniscus recovery mechanical factors in 4 aspects. Research shows that it has a good application prospect and wider space for meniscus tissue engineering repair of exercise-induced meniscus injury. But in practical application, the meniscus tissue engineering scaffold construction, research on extra cellular matrix composite and its tissue compatibility, repair after tissue engineering meniscus stress stimulation and can withstand the mechanical factors the problem is still the meniscus tissue engineering problems.


2021 ◽  
Vol 191 ◽  
pp. 500-513
Author(s):  
Maryam Abdollahi Asl ◽  
Saeed Karbasi ◽  
Saeed Beigi-Boroujeni ◽  
Soheila Zamanlui Benisi ◽  
Mahdi Saeed

Author(s):  
Xavier Barceló ◽  
Stefan Scheurer ◽  
Rajesh Lakshmanan ◽  
Cathal J Moran ◽  
Fiona Freeman ◽  
...  

3D bioprinting has the potential to transform the field of regenerative medicine as it enables the precise spatial patterning of biomaterials, cells and biomolecules to produce engineered tissues. Although numerous tissue engineering strategies have been developed for meniscal repair, the field has yet to realize an implant capable of completely regenerating the tissue. This paper first summarized existing meniscal repair strategies, highlighting the importance of engineering biomimetic implants for successful meniscal regeneration. Next, we reviewed how developments in 3D (bio)printing are accelerating the engineering of functional meniscal tissues and the development of implants targeting damaged or diseased menisci. Some of the opportunities and challenges associated with use of 3D bioprinting for meniscal tissue engineering are identified. Finally, we discussed key emerging research areas with the capacity to enhance the bioprinting of meniscal grafts.


2022 ◽  
pp. 107-132
Author(s):  
Jay Trivedi ◽  
Chathuraka T. Jayasuriya

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