scholarly journals Hydroxyapatite sonosensitization of ultrasound‐triggered, thermally responsive hydrogels: An on‐demand delivery system for bone repair applications

2021 ◽  
Author(s):  
Tanya Levingstone ◽  
Badriah Ali ◽  
Cathal Kearney ◽  
Nicholas Dunne
Keyword(s):  
Delivery System ◽  
Bone Repair ◽  
On Demand ◽  
Thermally Responsive ◽  
Responsive Hydrogels

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsy

2022 ◽  
Vol 8 (2) ◽  
Author(s):  
Di Wu ◽  
Fan Fei ◽  
Qi Zhang ◽  
Xia Wang ◽  
Yiwei Gong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Brain Targeting ◽  
On Demand

Electroresponsive and synergistic brain-targeting nanoparticles improve efficacy of pharmacotherapy for epilepsy.

scholarly journals Cell Type Influences Local Delivery of Biomolecules from a Bioinspired Apatite Drug Delivery System

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1703 ◽  
Author(s):  
Jumana Alhamdi ◽  
Emily Jacobs ◽  
Gloria Gronowicz ◽  
Nadia Benkirane-Jessel ◽  
Marja Hurley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Barrier Layer ◽  
Bone Repair ◽  
Bone Morphogenetic Protein 2 ◽  
Raw 264.7 ◽  
Osteoprogenitor Cell ◽  
Calvarial Bone ◽  
Cytotoxic Factor

Recently, the benefit of step-wise sequential delivery of fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 from a bioinspired apatite drug delivery system on mouse calvarial bone repair was demonstrated. The thicknesses of the nanostructured poly-l-Lysine/poly-l-Glutamic acid polyelectrolyte multilayer (PEM) and the bone-like apatite barrier layer that make up the delivery system, were varied. The effects of the structural variations of the coating on the kinetics of cell access to a cytotoxic factor delivered by the layered structure were evaluated. FGF-2 was adsorbed into the outer PEM, and cytotoxic antimycin-A (AntiA) was adsorbed to the substrate below the barrier layer to detect the timing of the cell access. While MC3T3-E1 osteoprogenitor cells accessed AntiA after three days, the RAW 264.7 macrophage access occurred within 4 h, unless the PEM layer was removed, in which case the results were reversed. Pits were created in the coating by the RAW 264.7 macrophages and initiated delivery, while the osteoprogenitor cell access to drugs occurred through a solution-mediated coating dissolution, at junctions between the islands of crystals. Macrophage-mediated degradation is therefore a mechanism that controls drug release from coatings containing bioinspired apatite.

In vitro study of SDF-1α-loaded injectable and thermally responsive hydrogels for adipose stem cell therapy by SDF-1/CXCR4 axis

2020 ◽  
Vol 8 (45) ◽  
pp. 10360-10372
Author(s):  
Siaka Fadera ◽  
Nai-Chen Cheng ◽  
Tai-Horng Young ◽  
I-Chi Lee
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
In Vitro Study ◽  
Adipose Stem Cell ◽  
Thermally Responsive ◽  
Ischemic Diseases ◽  
Responsive Hydrogels ◽  
Cxcr4 Axis

Thermoresponsive and injectable CS/βGP/HA hydrogels may provide an alternative for treating ischemic diseases via SDF-1/CXCR4 axis for ASC recruitment and retention.

scholarly journals Polymer microchamber arrays for geometry-controlled drug release: a functional study in human cells of neuronal phenotype

2019 ◽  
Vol 7 (6) ◽  
pp. 2358-2371 ◽  
Author(s):  
Olga Kopach ◽  
Kayiu Zheng ◽  
Olga A. Sindeeva ◽  
Meiyu Gai ◽  
Gleb B. Sukhorukov ◽  
...  
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Functional Study ◽  
Specific Drug ◽  
Polyelectrolyte Multilayer ◽  
Site Specific ◽  
Neuronal Phenotype ◽  
On Demand ◽  
Cargo Delivery

Polyelectrolyte multilayer (PEM) microchambers can provide a versatile cargo delivery system enabling rapid, site-specific drug release on demand.

scholarly journals Hybrid-silica nanoparticles as a delivery system of the natural biocide carvacrol

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36712-36721
Author(s):  
Chana G. Sokolik ◽  
Jean-Paul Lellouche
Keyword(s):  
Essential Oils ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Antibacterial Agent ◽  
On Demand ◽  
Hybrid Silica

The authors fabricated hybrid-silica NPs incorporating the natural antibiotic carvacrol from essential oils covalently with an enzymatically cleavable bond. They are a safe, on-demand antibacterial agent.

Magneto-thermally responsive hydrogels for bladder cancer treatment: Therapeutic efficacy and in vivo biodistribution

2015 ◽  
Vol 136 ◽  
pp. 625-633 ◽  
Author(s):  
Manish K. Jaiswal ◽  
Lina Pradhan ◽  
Shaleen Vasavada ◽  
Mrinmoy De ◽  
H.D. Sarma ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Treatment ◽  
Therapeutic Efficacy ◽  
Thermally Responsive ◽  
In Vivo Biodistribution ◽  
Responsive Hydrogels
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