High porous electrospun poly(ε‐caprolactone)/gelatin/ MgO scaffolds preseeded with endometrial stem cells promote tissue regeneration in full‐thickness skin wounds: An in vivo study

2020 ◽  
Vol 108 (7) ◽  
pp. 2961-2970 ◽  
Author(s):  
Shima Ababzadeh ◽  
Ali Farzin ◽  
Arash Goodarzi ◽  
Roya Karimi ◽  
Morteza Sagharjoghi Farahani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tissue Regeneration ◽  
In Vivo Study ◽  
Skin Wounds ◽  
Full Thickness ◽  
Endometrial Stem Cells ◽  
Full Thickness Skin ◽  
Thickness Skin

Exosome loaded alginate hydrogel promotes tissue regeneration in full‐thickness skin wounds: An in vivo study

2019 ◽  
Vol 108 (3) ◽  
pp. 545-556 ◽  
Author(s):  
Shilan Shafei ◽  
Mehdi Khanmohammadi ◽  
Reza Heidari ◽  
Hossein Ghanbari ◽  
Vajihe Taghdiri Nooshabadi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
In Vivo Study ◽  
Skin Wounds ◽  
Full Thickness ◽  
Alginate Hydrogel ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Silymarin enhanced fibroblast proliferation and tissue regeneration in full thickness skin wounds in rat models; a stereological study

2013 ◽  
Vol 17 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Soheil Ashkani-Esfahani ◽  
Yasaman Emami ◽  
Elmira Esmaeilzadeh ◽  
Fereshteh Bagheri ◽  
Mohammad Reza Namazi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Skin Wounds ◽  
Fibroblast Proliferation ◽  
Full Thickness ◽  
Rat Models ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Hair Follicle Morphogenesis in the Treatment of Mouse Full-Thickness Skin Defects Using Composite Human Acellular Amniotic Membrane and Adipose Derived Mesenchymal Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Wu Minjuan ◽  
Xiong Jun ◽  
Shao Shiyun ◽  
Xu Sha ◽  
Ni Haitao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hair Follicle ◽  
Amniotic Membrane ◽  
Functional Restoration ◽  
Skin Wounds ◽  
Full Thickness ◽  
Skin Defects ◽  
Full Thickness Skin ◽  
Thickness Skin

Early repair of skin injury and maximal restoration of the function and appearance have become important targets of clinical treatment. In the present study, we observed the healing process of skin defects in nude mice and structural characteristics of the new skin after transplantation of isolated and cultured adipose derived mesenchymal stem cells (ADMSCs) onto the human acellular amniotic membrane (AAM). The result showed that ADMSCs were closely attached to the surface of AAM and grew well 24 h after seeding. Comparison of the wound healing rate at days 7, 14, and 28 after transplantation showed that ADMSCs seeded on AAM facilitated the healing of full-thickness skin wounds more effectively as compared with either hAM or AAM alone, indicating that ADMSCs participated in skin regeneration. More importantly, we noticed a phenomenon of hair follicle development during the process of skin repair. Composite ADMSCs and AAM not only promoted the healing of the mouse full-thickness defects but also facilitated generation of the appendages of the affected skin, thus promoting restoration of the skin function. Our results provide a new possible therapy idea for the treatment of skin wounds with respect to both anatomical regeneration and functional restoration.

scholarly journals Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122359 ◽  
Author(s):  
Paul P. Bonvallet ◽  
Matthew J. Schultz ◽  
Elizabeth H. Mitchell ◽  
Jennifer L. Bain ◽  
Bonnie K. Culpepper ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Skin Wounds ◽  
Full Thickness ◽  
Electrospun Scaffolds ◽  
Full Thickness Skin ◽  
Thickness Skin

Mesenchymal stem cells combined with an artificial dermal substitute improve repair in full-thickness skin wounds

Burns ◽  
2012 ◽  
Vol 38 (8) ◽  
pp. 1143-1150 ◽  
Author(s):  
Dilmar Leonardi ◽  
Daniel Oberdoerfer ◽  
Marilda C. Fernandes ◽  
Rosalva T. Meurer ◽  
Gustavo A. Pereira-Filho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dermal Substitute ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds

2021 ◽  
Vol 8 ◽  
Author(s):  
Miguel Luis Obaíd ◽  
Juan Pablo Camacho ◽  
Marianne Brenet ◽  
Rocío Corrales-Orovio ◽  
Felipe Carvajal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase 1 ◽  
Skin Wounds ◽  
Full Thickness ◽  
Clinical Trial Registration ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Photosynthetic Cells

Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in several in vitro and in vivo models; however, no data is available about their safety in human patients. Here, an early phase-1 clinical trial (ClinicalTrials.gov identifier: NCT03960164, https://clinicaltrials.gov/ct2/show/NCT03960164) is presented to evaluate the safety and feasibility of implanting photosynthetic scaffolds for dermal regeneration in eight patients with full-thickness skin wounds. Overall, this trial shows that the presence of the photosynthetic microalgae Chlamydomonas reinhardtii in the implanted scaffolds did not trigger any deleterious local or systemic immune responses in a 90 days follow-up, allowing full tissue regeneration in humans. The results presented here represent the first attempt to treat patients with photosynthetic cells, supporting the translation of photosynthetic therapies into clinics.Clinical Trial Registration:www.clinicaltrials.gov/ct2/show/NCT03960164, identifier: NCT03960164.

scholarly journals Effect of Bone Marrow Derived Mesenchymal Stem Cells on Healing of Induced Full-Thickness Skin Wounds in Albino Rat

2013 ◽  
Vol 6 (1) ◽  
pp. 12-25 ◽  
Author(s):  
Hend Shafik Basiouny ◽  
Nagla Mohamed Salama ◽  
Zeinab Mohamed El Maadawi ◽  
Eman Abas Farag
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Skin Wounds ◽  
Full Thickness ◽  
Albino Rat ◽  
Full Thickness Skin ◽  
Thickness Skin
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