Exosome loaded alginate hydrogel promotes tissue regeneration in full‐thickness skin wounds: An in vivo study

2019 ◽  
Vol 108 (3) ◽  
pp. 545-556 ◽  
Author(s):  
Shilan Shafei ◽  
Mehdi Khanmohammadi ◽  
Reza Heidari ◽  
Hossein Ghanbari ◽  
Vajihe Taghdiri Nooshabadi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
In Vivo Study ◽  
Skin Wounds ◽  
Full Thickness ◽  
Alginate Hydrogel ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Silymarin enhanced fibroblast proliferation and tissue regeneration in full thickness skin wounds in rat models; a stereological study

2013 ◽  
Vol 17 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Soheil Ashkani-Esfahani ◽  
Yasaman Emami ◽  
Elmira Esmaeilzadeh ◽  
Fereshteh Bagheri ◽  
Mohammad Reza Namazi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Skin Wounds ◽  
Fibroblast Proliferation ◽  
Full Thickness ◽  
Rat Models ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals Microporous Dermal-Mimetic Electrospun Scaffolds Pre-Seeded with Fibroblasts Promote Tissue Regeneration in Full-Thickness Skin Wounds

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122359 ◽  
Author(s):  
Paul P. Bonvallet ◽  
Matthew J. Schultz ◽  
Elizabeth H. Mitchell ◽  
Jennifer L. Bain ◽  
Bonnie K. Culpepper ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Skin Wounds ◽  
Full Thickness ◽  
Electrospun Scaffolds ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals A First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds

2021 ◽  
Vol 8 ◽  
Author(s):  
Miguel Luis Obaíd ◽  
Juan Pablo Camacho ◽  
Marianne Brenet ◽  
Rocío Corrales-Orovio ◽  
Felipe Carvajal ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase 1 ◽  
Skin Wounds ◽  
Full Thickness ◽  
Clinical Trial Registration ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Photosynthetic Cells

Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in several in vitro and in vivo models; however, no data is available about their safety in human patients. Here, an early phase-1 clinical trial (ClinicalTrials.gov identifier: NCT03960164, https://clinicaltrials.gov/ct2/show/NCT03960164) is presented to evaluate the safety and feasibility of implanting photosynthetic scaffolds for dermal regeneration in eight patients with full-thickness skin wounds. Overall, this trial shows that the presence of the photosynthetic microalgae Chlamydomonas reinhardtii in the implanted scaffolds did not trigger any deleterious local or systemic immune responses in a 90 days follow-up, allowing full tissue regeneration in humans. The results presented here represent the first attempt to treat patients with photosynthetic cells, supporting the translation of photosynthetic therapies into clinics.Clinical Trial Registration:www.clinicaltrials.gov/ct2/show/NCT03960164, identifier: NCT03960164.

scholarly journals Topical Nicotinamide Improves Tissue Regeneration in Excisional Full-Thickness Skin Wounds: A Stereological and Pathological Study

2015 ◽  
Vol 20 (4) ◽  
Author(s):  
Soheil Ashkani Esfahani ◽  
Mahsima Khoshneviszadeh ◽  
Mohammad Reza Namazi ◽  
Ali Noorafshan ◽  
Bita Geramizadeh ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Skin Wounds ◽  
Full Thickness ◽  
Pathological Study ◽  
Full Thickness Skin ◽  
Thickness Skin

Effect of Fibrin-binding Synthetic Oligopeptide on the Healing of Full-thickness Skin Wounds in Streptozotocin-induced Diabetic Rats

2012 ◽  
Vol 19 (7) ◽  
pp. 1321-1328
Author(s):  
Jae-Eun Chung ◽  
Yun-Jeong Kim ◽  
Yoon-Jeong Park ◽  
Ki-Tae Koo ◽  
Yang-Jo Seol ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Skin Wounds ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin

Nanofiber-acellular dermal matrix as a bilayer scaffold containing mesenchymal stem cell for healing of full-thickness skin wounds

2018 ◽  
Vol 375 (3) ◽  
pp. 709-721 ◽  
Author(s):  
Mohamad Javad Mirzaei-parsa ◽  
Hossein Ghanbari ◽  
Behnam Alipoor ◽  
Amirhossein Tavakoli ◽  
Mohammad Reza H. Najafabadi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Acellular Dermal Matrix ◽  
Skin Wounds ◽  
Full Thickness ◽  
Dermal Matrix ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Acellular Dermal
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