scholarly journals In vitro oxidative degradation of a spinal posterior dynamic stabilization device

2017 ◽  
Vol 106 (3) ◽  
pp. 1237-1244 ◽  
Author(s):  
Bernard M. Lawless ◽  
Daniel M. Espino ◽  
Duncan E.T. Shepherd
Keyword(s):  
Oxidative Degradation ◽  
Dynamic Stabilization ◽  
Posterior Dynamic Stabilization

Facet Translation Analysis in the Lumbar Spine: An Application in Posterior Dynamic Stabilization

2012 ◽  
Author(s):  
Daniel J. Cook ◽  
Matthew S. Yeager ◽  
Boyle C. Cheng
Keyword(s):  
Lumbar Spine ◽  
Measurement Technique ◽  
Healthy Adult ◽  
Surgical Intervention ◽  
Dynamic Stabilization ◽  
Disc Disease ◽  
Human Lumbar Spine ◽  
Translation Analysis ◽  
Posterior Dynamic Stabilization

Facet articulation in the human lumbar spine has not been thoroughly characterized with regard to the effects of degeneration or surgical intervention. Kozanek et al. investigated the translation and rotation of the facets in 11 healthy adult subjects during maximal voluntary bending [1]. Li et al. used the same measurement technique on a cohort of 10 patients with degenerative disc disease (DDD) and found some significant differences in facet motion compared to a cohort of healthy patients [2]. Jegapragasan et al. investigated facet translations in intact lumbar spines in vitro and found the technique of facet translation analysis (FTA) to yield significantly different results compared to a similar analysis based on a vertebral body based coordinate system [3]. This abstract describes the application of this FTA technique in evaluating a posterior dynamic stabilization (PDS) system.

scholarly journals In VitroComparison of Dynesys, PEEK, and Titanium Constructs in the Lumbar Spine

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Matthew S. Yeager ◽  
Daniel J. Cook ◽  
Boyle C. Cheng
Keyword(s):  
Tracking System ◽  
Dynamic Stabilization ◽  
Lateral Bending ◽  
Adjacent Level ◽  
Flexion Extension ◽  
Intact Condition ◽  
Study Support ◽  
Posterior Dynamic Stabilization ◽  
Adjacent Level Effects

Introduction. Pedicle based posterior dynamic stabilization systems aim to stabilize the pathologic spine while also allowing sufficient motion to mitigate adjacent level effects. Two flexible constructs that have been proposed to act in such a manner, the Dynesys Dynamic Stabilization System and PEEK rod, have yet to be directly comparedin vitroto a rigid Titanium rod.Methods. Human lumbar specimens were tested in flexion extension, lateral bending, and axial torsion to evaluate the following conditions at L4-L5: Intact, Dynesys, PEEK rod, Titanium rod, and Destabilized. Intervertebral range of motion, interpedicular travel, and interpedicular displacement metrics were evaluated from 3rd-cycle data using an optoelectric tracking system.Results. Statistically significant decreases in ROM compared to Intact and Destabilized conditions were detected for the instrumented conditions during flexion extension and lateral bending. AT ROM was significantly less than Destabilized but not the Intact condition. Similar trends were found for interpedicular displacement in all modes of loading; however, interpedicular travel trends were less consistent. More importantly, no metrics under any mode of loading revealed significant differences between Dynesys, PEEK, and Titanium.Conclusion. The results of this study support previous findings that Dynesys and PEEK constructs behave similarly to a Titanium rodin vitro.

scholarly journals Newly Emerging Airborne Pollutants: Current Knowledge of Health Impact of Micro and Nanoplastics

2021 ◽  
Vol 18 (6) ◽  
pp. 2997
Author(s):  
Alessio Facciolà ◽  
Giuseppa Visalli ◽  
Marianna Pruiti Ciarello ◽  
Angela Di Pietro
Keyword(s):  
Surface Area ◽  
Current Knowledge ◽  
Oxidative Degradation ◽  
Health Impact ◽  
Outdoor Exposure ◽  
Environmental Matrices ◽  
Potential Health ◽  
Bodily Fluids

Plastics are ubiquitous persistent pollutants, forming the most representative material of the Anthropocene. In the environment, they undergo wear and tear (i.e., mechanical fragmentation, and slow photo and thermo-oxidative degradation) forming secondary microplastics (MPs). Further fragmentation of primary and secondary MPs results in nanoplastics (NPs). To assess potential health damage due to human exposure to airborne MPs and NPs, we summarize the evidence collected to date that, however, has almost completely focused on monitoring and the effects of airborne MPs. Only in vivo and in vitro studies have assessed the toxicity of NPs, and a standardized method for their analysis in environmental matrices is still missing. The main sources of indoor and outdoor exposure to these pollutants include synthetic textile fibers, rubber tires, upholstery and household furniture, and landfills. Although both MPs and NPs can reach the alveolar surface, the latter can pass into the bloodstream, overcoming the pulmonary epithelial barrier. Despite the low reactivity, the number of surface area atoms per unit mass is high in MPs and NPs, greatly enhancing the surface area for chemical reactions with bodily fluids and tissue in direct contact. This is proven in polyvinyl chloride (PVC) and flock workers, who are prone to persistent inflammatory stimulation, leading to pulmonary fibrosis or even carcinogenesis.

scholarly journals Evaluation of Effect of Posterior Dynamic Stabilization IntraSPIN System on Sagittal Spinal Balance using EOS® X-Ray Imaging System

2017 ◽  
Vol 08 (04) ◽  
Author(s):  
Simona Bistazzoni ◽  
Michelangelo De Angelis ◽  
Manuela D ercole ◽  
Carmela Chiaramonte ◽  
Antonio Carotenuto ◽  
...  
Keyword(s):  
Imaging System ◽  
Dynamic Stabilization ◽  
Spinal Balance ◽  
X Ray ◽  
X Ray Imaging ◽  
Posterior Dynamic Stabilization ◽  
Sagittal Spinal Balance

Antioxidative properties of Sambacus nigra extracts

2015 ◽  
Vol 69 (9) ◽  
Author(s):  
Dominika Topoľská ◽  
Katarína Valachová ◽  
Peter Rapta ◽  
Stanislav Šilhár ◽  
Elena Panghyová ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Radical Scavenging ◽  
Oxidative Degradation ◽  
Protective Effects ◽  
Radical Scavenging Capacity ◽  
Scavenging Capacity ◽  
Diammonium Salt ◽  
Dose Dependent ◽  
Oxidative System

AbstractPotential protective effects of elderberry (Sambucus nigra) extracts against oxidative degradation of hyaluronan (HA) were detected in vitro. To induce free-radical-mediated HA degradation, Weissberger’s biogenic oxidative system, which mimics the situation of acute inflammation, was applied. Time- and dose-dependent changes of dynamic viscosity of the HA solutions in the presence and absence of two elderberry extracts produced in 2006 and 2012 were recorded by rotational viscometry (RV). Radical scavenging capacity of both extracts was investigated by the spectrocolorimetric ABTS [2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt] assay and the “inverted” ABTS assay. Oxygen consumption of the system oxidizing HA either in the absence or presence of the elderberry extracts was determined. The results of RV revealed that an addition of the newer extract (2012) promoted the inhibition of HA degradation more markedly compared to the older extract (2006). The same effect of both extracts on ABTS

scholarly journals The Interspinous Spacer: A New Posterior Dynamic Stabilization Concept for Prevention of Adjacent Segment Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Antoine Nachanakian ◽  
Antonios El Helou ◽  
Moussa Alaywan
Keyword(s):  
Lumbar Spine ◽  
Preventive Measure ◽  
Radicular Pain ◽  
Dynamic Stabilization ◽  
Adjacent Segment Disease ◽  
Neurogenic Claudication ◽  
Adjacent Segment ◽  
Disability Score ◽  
Interspinous Spacer ◽  
Posterior Dynamic Stabilization

Introduction. Posterior Dynamic stabilization using the interspinous spacer device is a known to be used as an alternative to rigid fusion in neurogenic claudication patients in the absence of macro instability. Actually, it plays an important in the management of adjacent segment disease in previously fused lumbar spine.Materials and Method. We report our experience with posterior dynamic stabilization using an interspinous spacer. 134 cases performed in our institution between September 2008 and August 2012 with different lumbar spine pathologies. The ages of our patients were between 40 and 72 years, with a mean age of 57 years. After almost 4 years of follow up in our patient and comparing their outcome to our previous serious we found that in some case the interspinous distracter has an important role not only in the treatment of adjacent segment disease but also in its prevention.Results and Discussion. Clinical improvement was noted in ISD-treated patients, with high satisfaction rate. At first, radicular pain improves with more than 3/10 reduction of the mean score on visual analog scale (VAS). In addition, disability score as well as disc height and lordotic angle showed major improvement at 3 to 6 months post operatively. And, no adjacent segment disease was reported in the patient operated with interspinous spacer.Conclusion. The interspinous spacer is safe and efficient modality to be used not only as a treatment of adjacent segment disease but also as a preventive measure in patients necessitating rigid fusion.

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