Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels

2016 ◽  
Vol 105 (8) ◽  
pp. 2292-2300 ◽  
Author(s):  
Meiling Zhu ◽  
Qian Feng ◽  
Yuxin Sun ◽  
Gang Li ◽  
Liming Bian
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Cartilaginous Matrix ◽  
Matrix Components

Effect of electrical stimulation on chondrogenic differentiation of mesenchymal stem cells cultured in hyaluronic acid – Gelatin injectable hydrogels

2020 ◽  
Vol 134 ◽  
pp. 107536 ◽  
Author(s):  
Juan Jairo Vaca-González ◽  
Sandra Clara-Trujillo ◽  
María Guillot-Ferriols ◽  
Joaquín Ródenas-Rochina ◽  
María J. Sanchis ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Hyaluronic Acid ◽  
Chondrogenic Differentiation ◽  
Injectable Hydrogels ◽  
Cells Cultured

scholarly journals Mesenchymal stem cells and hyaluronic acid for bone grafting

2018 ◽  
Vol 29 ◽  
pp. 55-55 ◽  
Author(s):  
Eduardo Teixeira ◽  
Daniel Boeckel ◽  
Patricia Sesterheim ◽  
Roberta Fulginiti ◽  
Rosemay Shinkai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Bone Grafting

Hyaluronic acid facilitates chondrogenesis and matrix deposition of human adipose derived mesenchymal stem cells and human chondrocytes co-cultures

2017 ◽  
Vol 52 ◽  
pp. 130-144 ◽  
Author(s):  
Elisabeth Amann ◽  
Paul Wolff ◽  
Ernst Breel ◽  
Martijn van Griensven ◽  
Elizabeth R. Balmayor
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Human Chondrocytes ◽  
Matrix Deposition

Adipogenic Mesenchymal Stem Cells and Hyaluronic Acid as a Cellular Compound for Bone Tissue Engineering

2019 ◽  
Vol 30 (3) ◽  
pp. 777-783 ◽  
Author(s):  
Daniel Goncalves Boeckel ◽  
Patrícia Sesterheim ◽  
Thiago Rodrigues Peres ◽  
Adolpho Herbert Augustin ◽  
Krista Minéia Wartchow ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals Dual Network Hydrogels Incorporated with Bone Morphogenic Protein-7-Loaded Hyaluronic Acid Complex Nanoparticles for Inducing Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 613
Author(s):  
Qing Min ◽  
Jiaoyan Liu ◽  
Yuchen Zhang ◽  
Bin Yang ◽  
Ying Wan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Chondrogenic Differentiation ◽  
Sol Gel ◽  
Bone Morphogenic Protein ◽  
Cartilage Tissue ◽  
Acid Complex ◽  
Composite Gels ◽  
Bone Morphogenic Protein 7

Alginate-poloxamer (ALG-POL) copolymer with optimal POL content was synthesized, and it was combined with silk fibroin (SF) for building ALG-POL/SF dual network hydrogels. Hyaluronic acid(HA)/chitosan-poly(dioxanone)(CH-PDO) complex nanoparticles (NPs) with optimized composition and high encapsulation efficiency were employed as a vehicle for loading bone morphogenic protein-7 (BMP-7). BMP-7-loaded HA/CH-PDO NPs were incorporated into ALG-POL/SF hydrogel for constructing composite gels to achieve controlled release of BMP-7. These gels showed thermosensitive sol-gel transitions near physiological temperature and pH; and they were tested to be elastic, tough and strong. Some gels exhibited abilities to administer the BMP-7 release in nearly linear manners for a few weeks. Synovium-derived mesenchymal stem cells (SMSCs) were seeded into optimally fabricated gels for assessing their chondrogenic differentiation potency. Real-time PCR analyses showed that the blank ALG-POL/SF gels were not able to induce the chondrogenic differentiation of SMSCs, whereas SMSCs were detected to significantly express cartilage-related genes once they were seeded in the BMP-7-loaded ALG-POL/SF gel for two weeks. The synthesis of cartilaginous matrix components further confirmed that SMSCs seeded in the BMP-7-loaded ALG-POL/SF gel differentiated toward chondrogenesis. Results suggest that BMP-7-loaded ALG-POL/SF composite gels can function as a promising biomaterial for cartilage tissue engineering applications.

Additive nanocomplexes of cationic lipopolymers for improved non-viral gene delivery to mesenchymal stem cells

2015 ◽  
Vol 3 (19) ◽  
pp. 3972-3982 ◽  
Author(s):  
Remant Bahadur KC ◽  
Cezary Kucharski ◽  
Hasan Uludağ
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Gene Delivery ◽  
Viral Gene ◽  
Viral Gene Delivery

Additive polyplexes composed of cationic lipopolymers and hyaluronic acid–pDNA combination for implementing gene delivery to mesenchymal stem cells.

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