Tumor homing indocyanine green encapsulated micelles for near infrared and photoacoustic imaging of tumors

2016 ◽  
Vol 104 (4) ◽  
pp. 825-834 ◽  
Author(s):  
Saji Uthaman ◽  
Joon-suk Bom ◽  
Hyeon Sik Kim ◽  
Johnson V. John ◽  
Hee-Seung Bom ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Tumor Homing

scholarly journals CONTRAST-ENHANCED PHOTOACOUSTIC IMAGING USING INDOCYANINE GREEN-CONTAINING NANOPARTICLES

2014 ◽  
Vol 07 (01) ◽  
pp. 1350029 ◽  
Author(s):  
JUNPING ZHONG ◽  
SIHUA YANG
Keyword(s):  
Indocyanine Green ◽  
Contrast Agents ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Signal Amplitude ◽  
Photoacoustic Signal ◽  
Infrared Wavelength ◽  
Contrast Enhanced ◽  
Human Use ◽  
Good Contrast

Contrast agents are attracting a great deal of attention in photoacoustic imaging. Here we introduce an exogenous contrast agent that provides high photoacoustic signal amplitude at the near-infrared wavelength. Our agents consist of Indocyanine green (ICG) and phospholipid–polyethylene glycol (PL–PEG), entitled ICG–PL–PEG nanoparticles. These nanoparticles have overcome numerous limitations of ICG, such as poor aqueous stability, concentration-dependent aggregation and lack of target specificity. ICG–PL–PEG nanoparticles are biocompatible and relatively nontoxic. All the components of ICG–PL–PEG nanoparticles have been approved for human use. Upon pulsed laser irradiation, the nanoparticles are more efficient in producing photoacoustic waves than ICG alone. The results showed that ICG–PL–PEG nanoparticles act as good contrast agents for photoacoustic imaging. These unique ICG–PL–PEG nanoparticles have great potential in clinical applications.

Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging

2019 ◽  
Vol 11 (50) ◽  
pp. 46437-46450 ◽  
Author(s):  
Behzad Changalvaie ◽  
Sangheon Han ◽  
Ehsan Moaseri ◽  
Federica Scaletti ◽  
Lauren Truong ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
J Aggregates

Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging

2021 ◽  
Vol 17 (7) ◽  
pp. 1339-1348
Author(s):  
Yaqin Wang ◽  
Wenting Shang ◽  
Jianping Xiong ◽  
Yu Liu ◽  
Ting Luo ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Drug Resistant ◽  
Tumor Aggressiveness ◽  
Tumor Invasiveness ◽  
Drug Resistance Prediction ◽  
Resistance Prediction

Studies have shown that a higher GSH level is related to more drug-resistant and invasiveness of a tumor. However, it is a great challenge to accurately imaging the GSH level in vivo, for its imaging intensity will interfered by different accumulation of probes in the tumor. Thus, we hypothesized ratiometric photoacoustic imaging that can be used to predict the drug-resistant and invasiveness of tumors by accurate GSH level imaging. In this study, we synthesized MnO2/Indocyanine Green (MnO2/ICG). It can be used as ratiometric photoacoustic (PA) imaging probe, for its absorption at 780 nm (Ab780) can be decreased and 680 nm (Ab680) remain unchanged upon GSH reduction. And our results confirmed that a lower PA absorption ratio (Ab780/Ab680) corresponded to a higher GSH level of the tumor. Besides, the near-infrared fluorescence (FI) imaging was used as an assistant, for it can be quenched upon GSH. Therefore, MnO2/ICG can predict the tumor invasiveness and drug resistance by imaging the GSH level. This study provides reference to predict the prognosis of tumors by imaging the metabolic biomarker of tumors.

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Indocyanine green near infrared technology in demarcating midplane during pure laparoscopic donor hepatectomy: Useful but not necessary.

2021 ◽  
Author(s):  
Vishal Chorasiya ◽  
Qaleem Mohammed ◽  
Kausar Makki ◽  
Arif Ali khan ◽  
Furquan Ahmed ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Donor Hepatectomy ◽  
Infrared Technology
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