Development of tissue-engineered self-expandable aortic stent grafts (Bio stent grafts) using in-body tissue architecture technology in beagles

2014 ◽  
Vol 103 (2) ◽  
pp. 381-386 ◽  
Author(s):  
Hidetake Kawajiri ◽  
Takeshi Mizuno ◽  
Takeshi Moriwaki ◽  
Hatsue Ishibashi-Ueda ◽  
Masashi Yamanami ◽  
...  
Keyword(s):  
Body Tissue ◽  
Tissue Architecture ◽  
Stent Grafts

Long-term outcomes of patch tracheoplasty using collagenous tissue membranes (biosheets) produced by in-body tissue architecture in a beagle model

Surgery Today ◽  
2019 ◽  
Vol 49 (11) ◽  
pp. 958-964
Author(s):  
Satoshi Umeda ◽  
Yasuhide Nakayama ◽  
Takeshi Terazawa ◽  
Ryosuke Iwai ◽  
Shohei Hiwatashi ◽  
...  
Keyword(s):  
Body Tissue ◽  
Tissue Architecture ◽  
Long Term Outcomes ◽  
Collagenous Tissue

scholarly journals Three-Month Outcomes of Aortic Valve Reconstruction Using Collagenous Membranes (Biosheets) Produced by in Body Tissue Architecture in A Goat Model: A Preliminary Study

2020 ◽  
Author(s):  
Keitaro Okamoto ◽  
Tadashi Umeno ◽  
Tomoyuki Wada ◽  
Takashi Shuto ◽  
Hirofumi Anai ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Plastic Material ◽  
Control Valve ◽  
Body Tissue ◽  
Large Animal ◽  
Valve Leaflet ◽  
Tissue Architecture ◽  
Autologous Pericardium ◽  
Valve Reconstruction ◽  
Preliminary Study

Abstract Background: Autologous pericardium is widely used as a plastic material in intracardiac structures, in the pulmonary artery, and in aortic valve leaflets. For aortic valve reconstruction (AVRec) using the Ozaki procedure, it has produced excellent clinical results within a 10-year period. In-body tissue architecture (iBTA), which is based on the phenomenon of tissue encapsulation of foreign materials, can be used to prepare autologous prosthetic tissues. In this preliminary study, we examined whether biosheets can be used as valve leaflet material for glutaraldehyde-free AVRec by subchronic implantation experiments in goats and evaluated its performance compared with glutaraldehyde-treated autologous pericardium for AVRec. Methods: Biosheets were prepared by embedding molds for two months into the dorsal subcutaneous spaces of goats. Allogenic biosheets (n=4) cut into the shape of the valve were then implanted to the aortic valve annulus of four goats for three months without glutaraldehyde treatment. Autologous pericardium (n=4) was used as a control. Valve function was observed using echocardiography. Results: All goats survived the three-month study period. In biosheets, the leaflet surfaces were very smooth and, on histology, partially covered with a thin neointima (including endothelial cells). Biosheets were more thoroughly assimilated into the aortic root compared with autologous pericardium.Conclusions: For the first time, biosheets could be used for large animal AVRec without glutaraldehyde fixation. In this limited preliminary study, it was found that biosheets had superior engraftment and regeneration performance as an aortic valve leaflet material compared with autologous pericardium.

AUTOLOGOUS ARTIFICIAL HEART VALVES (BIOVALVES) BASED ON ???IN BODY TISSUE ARCHITECTURE??? TECHNOLOGY

ASAIO Journal ◽  
2006 ◽  
Vol 52 (2) ◽  
pp. 8A
Author(s):  
Kyoko Hayashida ◽  
Keiichi Kanda ◽  
Hitoshi Yaku ◽  
Yasuhide Nakayama
Keyword(s):  
Artificial Heart ◽  
Heart Valves ◽  
Body Tissue ◽  
Tissue Architecture ◽  
Artificial Heart Valves

Application of in-body tissue architecture–induced Biotube vascular grafts for vascular access: Proof of concept in a beagle dog model

2019 ◽  
Vol 21 (3) ◽  
pp. 314-321 ◽  
Author(s):  
Maya Furukoshi ◽  
Eisuke Tatsumi ◽  
Yasuhide Nakayama
Keyword(s):  
Vascular Access ◽  
Body Tissue ◽  
Internal Diameter ◽  
Proof Of Concept ◽  
Beagle Dogs ◽  
Tissue Architecture ◽  
First Choice ◽  
Type 3

Introduction: The first choice of vascular access for hemodialysis is an autogenous arteriovenous fistula, because prosthetic arteriovenous grafts have a high probability of failure. In this study, Biotubes, in-body tissue architecture–induced autologous collagenous tubes, were evaluated for their potential use as vascular access grafts. Three animal implantation models were developed using beagle dogs, and the in vivo performance of Biotubes was observed after implantation in the acute phase as a pilot study. Methods: Biotubes (internal diameter ca. 4.0 mm, length ca. 5.0 cm, and wall thickness ca. 0.7 mm) were prepared through subcutaneous embedding of specially designed molds in beagle dogs for 8 weeks. The Biotubes were then implanted between the common carotid artery and the jugular vein of beagles via three methods, including side-to-side (in) -end-to-end (out) as type 1 (n = 4), side-to-side (both) as type 2 (n = 4), and side-to-end (in) -end-to-side (out) as type 3 (n = 1 using a composite Biotube). Results: Although two cases in type 1 and 2 resulted in Biotube deformation, all cases were patent for 4 weeks and maintained a continuous turbulent flow. At 4 weeks after implantation, percutaneous puncture could be performed repeatedly without aneurysm formation or hemorrhage. Conclusion: Within a short implantation period, with limited animal numbers, this proof-of-concept study showed that Biotubes may have a high potential for use in vascular access.

Long-term animal implantation study of biotube-autologous small-caliber vascular graft fabricated by in-body tissue architecture

2011 ◽  
Vol 98B (1) ◽  
pp. 120-126 ◽  
Author(s):  
Taiji Watanabe ◽  
Keiichi Kanda ◽  
Masashi Yamanami ◽  
Hatsue Ishibashi-Ueda ◽  
Hitoshi Yaku ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Body Tissue ◽  
Tissue Architecture ◽  
Animal Implantation

1113 Evaluation in vitro of the function of an artificial substitute heart valve made in body tissue architecture technology

2007 ◽  
Vol 2007.5 (0) ◽  
pp. 293-294
Author(s):  
Masaaki ONOYAMA ◽  
Tsutomu TAJIKAWA ◽  
Kenkichi OHBA ◽  
Kyoko HAYASHIDA ◽  
Keiichi KANDA ◽  
...  
Keyword(s):  
Heart Valve ◽  
Body Tissue ◽  
Tissue Architecture ◽  
Made In

scholarly journals 708 Hydrodynamic functional evaluation of artificial substitute heart valve in body tissue architecture technology in vitro

2007 ◽  
Vol 2007.82 (0) ◽  
pp. _7-8_
Author(s):  
Masaaki ONOYAMA ◽  
Tsutomu TAJIKAWA ◽  
Kenkichi OHBA ◽  
Kyoko HAYASHIDA ◽  
Keiichi KANDA ◽  
...  
Keyword(s):  
Heart Valve ◽  
Body Tissue ◽  
Functional Evaluation ◽  
Tissue Architecture
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