Poly-cyclodextrin functionalized porous bioceramics for local chemotherapy and anticancer bone reconstruction

2013 ◽  
Vol 102 (6) ◽  
pp. 1130-1139 ◽  
Author(s):  
Feng Chai ◽  
Mohamed Abdelkarim ◽  
Thomas Laurent ◽  
Nicolas Tabary ◽  
Stephanie Degoutin ◽  
...  
Keyword(s):  
Bone Reconstruction ◽  
Local Chemotherapy ◽  
Porous Bioceramics

New Model of Bone Reconstruction Specially Designed for Skull Base Surgery—Long-Term Testing in Primates

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Cleopatra Charalampaki ◽  
Axel Heimann ◽  
Laszlo Kopacs ◽  
Oliver Kempski
Keyword(s):  
Skull Base ◽  
Skull Base Surgery ◽  
Bone Reconstruction ◽  
New Model

A New Era of Organ-Preserving Treatment in Pediatric Intraocular Retinoblastoma in Russia: A Multicenter Cohort Study

2018 ◽  
Vol 5 (1) ◽  
pp. 51-69 ◽  
Author(s):  
Тatiana L. Ushakova ◽  
Igor A. Тrofimov ◽  
Оlga V. Gorovtsova ◽  
Аndrey A. Yarovoy ◽  
Svetlana V. Saakyan ◽  
...  
Keyword(s):  
Gamma Knife ◽  
Systemic Chemotherapy ◽  
Focal Therapy ◽  
Primary Treatment ◽  
Local Chemotherapy ◽  
Multicenter Cohort Study ◽  
Cancer Disease ◽  
Tumor Spread ◽  
Group D

Background.Retinoblastoma (RB) is a life threatening cancer disease. A breakthrough in the treatment of children with RB is associated with the improvement of conservative treatment that was administered in at least one of the two tumor-affected eyes in most bilateral cases, that was chemotherapy both systemic and local (selective intra-arterial and intravitreal) in most cases combined with laser therapy, cryotherapy, or brachytherapy. The development of such techniques as local chemotherapy is focused on preservation of visual functions, reducing the number of enucleations and radiotherapy (RT) course. The success of the healing of RB is closely associated with a multidisciplinary approach to diagnosis and treatment, as well as specialized longterm follow-up clinical examination.Objective.eye and vision preservation against large intraocular tumors with different growth types and localization without the course of remote radiation therapy was the main purpose.Methods.In the period from September 2012 to January 2016, the study enrolled 45 patients with RB when at least one eye had intraocular tumor spread corresponding to the group C or D. According to the ABC international classification, patients have a relatively good prognosis for organ-preserving treatment. 4 of 18 children with bilateral RB had undergone primary enucleation of worse eye the worst eye, group E; 49 (77.8%) of the 63 affected eyes had features for groups C and D. In this study, no patient received local chemotherapy initially, only after prior systemic chemotherapy. Selective intra-arterial chemotherapy (SIAC) was applied to 41 patients (45 eyes; mean course number was 2), and 32 patients (34 eyes) had undergone intravitreal chemo therapy (IViC) (mean course number was 2). Focal therapy and local chemotherapy were the main methods of treatment for progression (new lesions on the retina) in 8 (16.3%) of 49 eyes with tumors of group C (n=1) and D (n=7); the relapse in 14 of 49 (new lesions on the retina) in eyes with tumors of group C (n=5) and D (n=6) and (new lesions on the retina and the vitreous) in eyes with tumors of group D (n=3) (28.5%), and stabilization of disease n=23 (46.9%). We should note that 2 patients underwent repeated course of in case of systemic chemotherapy, 1 patient — a Gamma Knife procedure due to registered disease stabilization, progression or relapse.Results.10 (20.4%) of 49 eyes saved due to the combined chemotherapy. In 45 patients diseasefree survival rate was 56.1±8.9 % (with mean follow-up period 26.9±2.5 months). 1 of 45 patients died from leukemia. 44 of 45 patients are alive without metastasis. The mean follow-up was 20 months (3 to 43 months). Eye salvage rate in group C — 14 (93.3%) of 15, in group D — 31 (91.2%) of 34.Conclusion.These methods: second line of systemic chemotherapy, RT, and a Gamma Knife procedure should be considered as a failure of primary treatment. Our study demonstrated a high efficacy of local chemotherapy with promissing techniques of conservation therapy, which safety increases due to experience.

Local Chemotherapy in Joint Tuberculosis

BMJ ◽  
1959 ◽  
Vol 1 (5115) ◽  
pp. 174-174
Author(s):  
H. Wehrlin
Keyword(s):  
Local Chemotherapy

scholarly journals Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?

2021 ◽  
Vol 28 (4) ◽  
pp. 2317-2325
Author(s):  
Luigi Bennardo ◽  
Francesco Bennardo ◽  
Amerigo Giudice ◽  
Maria Passante ◽  
Stefano Dastoli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gold Standard ◽  
Systemic Chemotherapy ◽  
Standard Treatment ◽  
Case Reports ◽  
Case Series ◽  
Surgical Removal ◽  
Local Chemotherapy

Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.

HA/MgO nanocrystals hybrid hydrogel integrated with the tough mechanical strength and the osteoinductive potential for bone reconstruction of diabetic rats

2020 ◽  
Author(s):  
Rui Chen ◽  
Hang-Bo Chen ◽  
Pengpeng Xue ◽  
Wai-Geng Yang ◽  
Lan-zi Luo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mechanical Strength ◽  
Bone Repair ◽  
Diabetic Rats ◽  
Regeneration Process ◽  
Bone Reconstruction ◽  
Hybrid Hydrogel ◽  
Osteoinductive Potential

Bone repair and regeneration process is markedly impaired in diabetes mellitus (DM). The similar intervening approaches developed for the normal healing conditions have been still adopted to combat the DM-associated...

scholarly journals Tissue-engineered autologous grafts for facial bone reconstruction

2016 ◽  
Vol 8 (343) ◽  
pp. 343ra83-343ra83 ◽  
Author(s):  
Sarindr Bhumiratana ◽  
Jonathan C. Bernhard ◽  
David M. Alfi ◽  
Keith Yeager ◽  
Ryan E. Eton ◽  
...  
Keyword(s):  
Bone Reconstruction ◽  
Facial Bone ◽  
Autologous Grafts

Porous Bioceramics (Open Cell Foams) Expanded in Vacuum

2006 ◽  
Vol 309-311 ◽  
pp. 1023-1026
Author(s):  
E.T. Uzumaki ◽  
C.S. Lambert
Keyword(s):  
Zirconium Oxide ◽  
Cell Structure ◽  
The Body ◽  
Carbon Coatings ◽  
Open Cell ◽  
Glass Foam ◽  
Open Cell Foams ◽  
Titanium Foam ◽  
Porous Bioceramics ◽  
Scanning Electron

In this study, porous bioceramics (titanium foam with diamond-like carbon coatings, glass foam and zirconium oxide foam) were produced using expansion in vacuum. The porosity, the pore size and pore morphology can be adjusted in agreement with the application. The different 3D structures were obtained by varying the parameters of the process. The microstructure and morphology of the porous materials were observed by scanning electron microscopy (SEM) and optical microscopy. The foam exhibit an open-cell structure with interconnected macropores, which provide the potential for tissue ingrowths and the transport of the body fluids.

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