Curcumin-Microsphere/IR820 Hybrid Bifunctional Hydrogels for In Situ Osteosarcoma Chemo-co-Thermal Therapy and Bone Reconstruction

2021 ◽  
Author(s):  
Bowen Tan ◽  
Yanting Wu ◽  
Yongzhi Wu ◽  
Kun Shi ◽  
Ruxia Han ◽  
...  
Keyword(s):  
Thermal Therapy ◽  
Bone Reconstruction

In vitro characterization of an injectable in situ forming composite system for bone reconstruction

2015 ◽  
Vol 119 ◽  
pp. 151-158 ◽  
Author(s):  
R. Dorati ◽  
C. Colonna ◽  
I. Genta ◽  
A. De Trizio ◽  
T. Modena ◽  
...  
Keyword(s):  
Composite System ◽  
Bone Reconstruction ◽  
In Situ Forming ◽  
In Vitro Characterization

Tissue-Light Interaction During Monitoring of Thermal Lesion Using Quantum Dot Mediated Fluorescence Thermometry

2011 ◽  
Author(s):  
Willard Hanson ◽  
Najma Abdollahzadeh ◽  
Bumsoo Han
Keyword(s):  
Diffusion Approximation ◽  
Treatment Options ◽  
Thermal Therapy ◽  
Temperature Dependent ◽  
Thermal Lesion ◽  
Tissue Phantom ◽  
Localized Heating ◽  
Light Interaction

Thermal therapy, destroying tumor in situ by localized heating, is emerging as one of the treatment options for benign and localized tumors. Despite many advantages of thermal therapy, its clinical application is still limited due to the lack of a reliable intraoperative monitoring technique of the thermal lesion. To address this challenge, an intraoperative thermometry technique has been proposed using the temperature-dependent fluorescence of quantum dots (QDs). Its feasibility is recently demonstrated by monitoring the spatiotemporal temperature during gold nanoshell-mediated heating. In the present study, the effects of tissue-light interaction on the QD-mediated thermometry were investigated both experimentally and theoretically so that the technique can be extended to in vivo applications. As for experimental investigation, the QD fluorescence through tissue phantom was characterized with varying the thickness of the phantom over a temperature range relevant to thermal therapy. The results showed that the QD fluorescence through tissue phantom was still linearly correlated to the local temperature, but the slope of the correlations decreased with the phantom thickness. As for theoretical investigation, the radiative transfer equation was reduced to the diffusion approximation, and the QD fluorescence through tissue phantom was predicted by numerically solving the diffusion approximation. The results confirmed that the diffusion approximation could describe the tissue-light interaction for the QD-mediated thermometry but further research is still required to improve the accuracy of the prediction.

Spatiotemporal Temperature Measurement Using Quantum Dot Thermometry During Nanoshell Mediated Thermal Therapy

2008 ◽  
Author(s):  
Bumsoo Han ◽  
Willard L. Hanson ◽  
Karim Bensalah ◽  
Altug Tuncel ◽  
Joshua Stern ◽  
...  
Keyword(s):  
Surgical Techniques ◽  
Thermal Therapy ◽  
Thermal Lesion ◽  
Major Drawback ◽  
Thermal Lesions ◽  
Minimally Invasive Surgical ◽  
Thermal Therapies ◽  
Diagnostic Technologies ◽  
Widespread Dissemination

Due to advances and routine use of various diagnostic technologies, tumors are increasingly detected at very early stages. Thus, there is growing interest in employing minimally invasive surgical techniques for the management of tumors. Many of these procedures are thermal therapies, in which localized thermal lesions, either hyperthermic or cryogenic, are created to destroy malignant tissue in situ. However, the major drawback to the widespread dissemination and acceptance of thermal therapy is the lack of a reliable real-time intraoperative monitoring technique of the thermal lesion.

Rendez vous with Saturn's rings

1984 ◽  
Vol 75 ◽  
pp. 743-759 ◽  
Author(s):  
Kerry T. Nock
Keyword(s):  
Solar Energy ◽  
Electric Propulsion ◽  
Power Source ◽  
Propulsion System ◽  
Low Thrust ◽  
Ring Plane ◽  
The Earth ◽  
Total Impulse ◽  
Saturn's Rings

ABSTRACTA mission to rendezvous with the rings of Saturn is studied with regard to science rationale and instrumentation and engineering feasibility and design. Future detailedin situexploration of the rings of Saturn will require spacecraft systems with enormous propulsive capability. NASA is currently studying the critical technologies for just such a system, called Nuclear Electric Propulsion (NEP). Electric propulsion is the only technology which can effectively provide the required total impulse for this demanding mission. Furthermore, the power source must be nuclear because the solar energy reaching Saturn is only 1% of that at the Earth. An important aspect of this mission is the ability of the low thrust propulsion system to continuously boost the spacecraft above the ring plane as it spirals in toward Saturn, thus enabling scientific measurements of ring particles from only a few kilometers.

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