Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel

2009 ◽  
Vol 91B (1) ◽  
pp. 163-171 ◽  
Author(s):  
So Jeong Yoon ◽  
Yong Hu Fang ◽  
Choon Hak Lim ◽  
Bum Shik Kim ◽  
Ho Sung Son ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ischemic Heart ◽  
Injectable Hydrogel

Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury

2018 ◽  
Vol 6 (19) ◽  
pp. 2982-2992 ◽  
Author(s):  
Kun Zhang ◽  
Zhenqing Shi ◽  
Jiankang Zhou ◽  
Qu Xing ◽  
Shanshan Ma ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Brain Injury ◽  
Sodium Alginate ◽  
Potential Application ◽  
Hydrogel Scaffold ◽  
Injectable Hydrogel ◽  
Tissue Scaffold

In this contribution, we developed an injectable hydrogel composed of sodium alginate and hyaluronic acid that acts as a tissue scaffold to create a more optimal microenvironment for the stem cells for potential application of traumatic brain injury implantation.

A rapid crosslinking injectable hydrogel for stem cell delivery, from multifunctional hyperbranched polymers via RAFT homopolymerization of PEGDA

2015 ◽  
Vol 6 (34) ◽  
pp. 6182-6192 ◽  
Author(s):  
Yixiao Dong ◽  
Yue Qin ◽  
Marie Dubaa ◽  
John Killion ◽  
Yongsheng Gao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
Hyperbranched Polymers ◽  
Cell Delivery ◽  
Injectable Hydrogel ◽  
Stem Cell Delivery

A novel injectable hydrogel for stem cell delivery was prepared from multifunctional hyperbranched polyPEGDA and thiolated hyaluronic acid.

The preparation and biocompatible evaluation of injectable dual crosslinking hyaluronic acid hydrogels as cytoprotective agents

2019 ◽  
Vol 7 (28) ◽  
pp. 4413-4423 ◽  
Author(s):  
Wanxu Cao ◽  
Junhui Sui ◽  
Mengcheng Ma ◽  
Yang Xu ◽  
Weimin Lin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Disulfide Bonds ◽  
Biomedical Applications ◽  
Click Reaction ◽  
Injectable Hydrogel ◽  
Good Biocompatibility ◽  
Hyaluronic Acid Hydrogel

An injectable dual crosslinking hyaluronic acid hydrogel was prepared by a thiol–ene click reaction and conversion between sulfhydryl and disulfide bonds. This injectable hydrogel exhibits good biocompatibility and potential biomedical applications.

scholarly journals Development of an in situ injectable hydrogel containing hyaluronic acid for neural regeneration

2020 ◽  
Vol 15 (5) ◽  
pp. 055005 ◽  
Author(s):  
Linh T B Nguyen ◽  
Chia-Chen Hsu ◽  
Hua Ye ◽  
Zhanfeng Cui
Keyword(s):  
Hyaluronic Acid ◽  
Neural Regeneration ◽  
Injectable Hydrogel

Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery

2017 ◽  
Vol 156 ◽  
pp. 403-408 ◽  
Author(s):  
Young-seok Jung ◽  
Wooram Park ◽  
Hyejin Park ◽  
Deok-Keun Lee ◽  
Kun Na
Keyword(s):  
Hyaluronic Acid ◽  
Injectable Hydrogel ◽  
Physical Mixing

scholarly journals A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

Polymers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 949 ◽  
Author(s):  
Gang Wang ◽  
Xiaodong Cao ◽  
Hua Dong ◽  
Lei Zeng ◽  
Chenxi Yu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Cell Activity ◽  
Cartilage Tissue Engineering ◽  
Diels Alder ◽  
Cartilage Tissue ◽  
Good Prospect ◽  
Crosslinking Reaction ◽  
Injectable Hydrogel

A hyaluronic acid (HA) based injectable hydrogel with gradually increasing mechanical properties was synthesized via photo-crosslinking reaction and thermal-induced Diels-Alder (DA) reaction. The injectable hydrogel can quickly gelate within 30 s by photo-crosslinking of HA-furan under the catalysis of lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). This injectable property is beneficial to keep the encapsulated cell activity and convenient for clinical operation. And the mechanical properties can be control from 4.86 to 10.66 kPa by exposure time. Then, the thermal-induced DA click chemistry further occurs between furan groups and maleimide groups which gradually promoted the crosslinking density of the injectable hydrogel. The mechanical properties of the injectable hydrogel can be promoted to 21 kPa. ATDC-5 cells were successfully encapsulated in the injectable hydrogel and showed good activity. All the results suggested that the injectable hydrogel with gradually increasing mechanical properties formed by photo-crosslinking reaction and thermal-induced DA reaction has a good prospect of application in cartilage tissue engineering.

A hyaluronic acid/cyclodextrin based injectable hydrogel for local doxorubicin delivery to solid tumors

2020 ◽  
Vol 589 ◽  
pp. 119879 ◽  
Author(s):  
Calogero Fiorica ◽  
Fabio Salvatore Palumbo ◽  
Giovanna Pitarresi ◽  
Roberto Puleio ◽  
Lucia Condorelli ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Solid Tumors ◽  
Injectable Hydrogel ◽  
Doxorubicin Delivery
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