The preparation and biocompatible evaluation of injectable dual crosslinking hyaluronic acid hydrogels as cytoprotective agents

2019 ◽  
Vol 7 (28) ◽  
pp. 4413-4423 ◽  
Author(s):  
Wanxu Cao ◽  
Junhui Sui ◽  
Mengcheng Ma ◽  
Yang Xu ◽  
Weimin Lin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Disulfide Bonds ◽  
Biomedical Applications ◽  
Click Reaction ◽  
Injectable Hydrogel ◽  
Good Biocompatibility ◽  
Hyaluronic Acid Hydrogel

An injectable dual crosslinking hyaluronic acid hydrogel was prepared by a thiol–ene click reaction and conversion between sulfhydryl and disulfide bonds. This injectable hydrogel exhibits good biocompatibility and potential biomedical applications.

Thiol-ene crosslinking polyamidoamine dendrimer-hyaluronic acid hydrogel system for biomedical applications

2016 ◽  
Vol 27 (8) ◽  
pp. 743-757 ◽  
Author(s):  
Xiangdong Bi ◽  
Aiye Liang ◽  
Yu Tan ◽  
Panita Maturavongsadit ◽  
Ashley Higginbothem ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Polyamidoamine Dendrimer ◽  
Hyaluronic Acid Hydrogel ◽  
Hydrogel System

Colloidal drug carries from (sub)micron hyaluronic acid hydrogel particles with tunable properties for biomedical applications

2010 ◽  
Vol 82 (3) ◽  
pp. 997-1003 ◽  
Author(s):  
Pinar Ilgin ◽  
Gulden Avci ◽  
Coskun Silan ◽  
Sema Ekici ◽  
Nahit Aktas ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Hydrogel Particles ◽  
Tunable Properties ◽  
Hyaluronic Acid Hydrogel

Study of a novel injectable hydrogel of human-like collagen and carboxymethylcellulose for soft tissue augmentation

e-Polymers ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bowen Liu ◽  
Xiaoxuan Ma ◽  
Chenhui Zhu ◽  
Yu Mi ◽  
Daidi Fan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Biomedical Applications ◽  
Soft Tissue Augmentation ◽  
Injectable Hydrogel ◽  
Amide Bonds ◽  
Tissue Augmentation ◽  
Biocompatibility Test ◽  
Good Biocompatibility ◽  
Equilibrium Swelling Ratio

Abstract A novel injectable hydrogel was fabricated by human-like collagen (HLC) and carboxymethylcellulose (CMC) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and adipic acid dihydrazide (ADH) as cross-linkers. The morphology and structure of the hydrogels were characterized by scanning electron microscope and Fourier transform infrared spectroscopy. The results showed that the HLC and CMC were successfully cross-linked through amide bonds and HLC could enhance the pore size of the composite, whereas CMC could be a strong backbone in the hydrogel to keep its appearance. The results of thermogravimetric analysis showed that the thermostability of HLC/CMC was strengthened significantly as compared with that of CMC. The tests of the equilibrium swelling ratio and in vitro degradability indicated that the HLC/CMC hydrogel possesses good water absorbing ability and slow degradability in vitro. Finally, biocompatibility test provided the possibility that HLC/CMC hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good biocompatibility.

scholarly journals Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1113
Author(s):  
Luis Andrés Pérez ◽  
Rebeca Hernández ◽  
José María Alonso ◽  
Raúl Pérez-González ◽  
Virginia Sáez-Martínez
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Diels Alder ◽  
Physiological Conditions ◽  
Mild Conditions ◽  
Thermoreversible Gelation ◽  
Schiff Base Formation ◽  
Hyaluronic Acid Hydrogel ◽  
Base Formation

Hyaluronic acid (HA) hydrogels display a wide variety of biomedical applications ranging from tissue engineering to drug vehiculization and controlled release. To date, most of the commercially available hyaluronic acid hydrogel formulations are produced under conditions that are not compatible with physiological ones. This review compiles the currently used approaches for the development of hyaluronic acid hydrogels under physiological/mild conditions. These methods include dynamic covalent processes such as boronic ester and Schiff-base formation and click chemistry mediated reactions such as thiol chemistry processes, azide-alkyne, or Diels Alder cycloaddition. Thermoreversible gelation of HA hydrogels at physiological temperature is also discussed. Finally, the most outstanding biomedical applications are indicated for each of the HA hydrogel generation approaches.

Development of a chitosan and hyaluronic acid hydrogel with potential for bioprinting utilization: A preliminary study

2021 ◽  
pp. 088532822110241
Author(s):  
Thaís Vieira de Souza ◽  
Sonia Maria Malmonge ◽  
Arnaldo R Santos
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Low Cost ◽  
Three Dimensional ◽  
Cell Encapsulation ◽  
Biologically Relevant ◽  
Vibrational Bands ◽  
Preliminary Study ◽  
Hyaluronic Acid Hydrogel ◽  
Direct Toxicity

Bioprinting is a technique that has been applied in the areas of tissue engineering and regenerative medicine (TERM). Natural polymer-based hydrogels are known for their favorable biocompatible properties, as well as attractive biomaterials for cell encapsulation. These hydrogels provide an aqueous three-dimensional environment with biologically relevant chemical and physical signals, mimicking the natural environment of the extracellular matrix (ECM). Chitosan (CHI) and hyaluronic acid (HA) have been widely researched for biomedical applications. Bioinks are “ink” formulations, usually hydrogels, that allow the printing of living cells. This work proposes the development of a low cost and simple chitosan CHI-AH hydrogel with potential to become a bioink. At physiological temperature, the biomaterials form a hydrogel. The material developed was characterized by the analysis of morphology, cytotoxicity, and cell viability. FTIR showed the characteristic vibrational bands of chitosan and HA. No difference in swelling was observed between the different formulations studied, although SEM showed architectural differences between the hydrogels obtained. Extract cytotoxicity testing showed that the hydrogel is not cytotoxic. The direct toxicity test also revealed the absence of toxicity, but the cells had difficulty migrating into the gel, probably because of its density. These data were confirmed by SEM. Further testing are ongoing to better understand the gel’s characteristics to improve the limitations found so far.

Synergistic regenerative effects of functionalized endometrial stromal cells with hyaluronic acid hydrogel in a murine model of uterine damage

2019 ◽  
Vol 89 ◽  
pp. 139-151 ◽  
Author(s):  
Yoon Young Kim ◽  
Kyu-Hyung Park ◽  
Yong Jin Kim ◽  
Moon Suk Kim ◽  
Hung Ching Liu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Murine Model ◽  
Stromal Cells ◽  
Endometrial Stromal Cells ◽  
Hyaluronic Acid Hydrogel

scholarly journals Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Beilei Gong ◽  
Yuanbing Shen ◽  
Huiyan Li ◽  
Xiaojun Li ◽  
Xia Huan ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Tumour Site ◽  
Polymer Shell ◽  
Potential System ◽  
Responsive Polymer ◽  
Good Biocompatibility ◽  
Spr Effect

AbstractOwing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.

scholarly journals Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 906
Author(s):  
Le Minh Tu Phan ◽  
Thuy Anh Thu Vo ◽  
Thi Xoan Hoang ◽  
Sungbo Cho
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
High Light ◽  
Conversion Materials ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Biomedical Field ◽  
Hydrogel Composites ◽  
Material Fabrication ◽  
Biomedical Fields

Recently, photothermal therapy (PTT) has emerged as one of the most promising biomedical strategies for different areas in the biomedical field owing to its superior advantages, such as being noninvasive, target-specific and having fewer side effects. Graphene-based hydrogels (GGels), which have excellent mechanical and optical properties, high light-to-heat conversion efficiency and good biocompatibility, have been intensively exploited as potential photothermal conversion materials. This comprehensive review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine. The latest advances in the synthesis strategies, unique properties and potential applications of photothermal-responsive GGel nanocomposites in biomedical fields are introduced in detail. This review aims to provide a better understanding of the current progress in GGel material fabrication, photothermal properties and potential PTT-based biomedical applications, thereby aiding in more research efforts to facilitate the further advancement of photothermal biomedicine.

Sign in / Sign up

Export Citation Format

Share Document