Multinozzle low-temperature deposition system for construction of gradient tissue engineering scaffolds

2009 ◽  
Vol 88B (1) ◽  
pp. 254-263 ◽  
Author(s):  
Li Liu ◽  
Zhuo Xiong ◽  
Yongnian Yan ◽  
Renji Zhang ◽  
Xiaohong Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Low Temperature ◽  
Tissue Engineering Scaffolds ◽  
Low Temperature Deposition ◽  
Temperature Deposition

scholarly journals Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Changyong Liu ◽  
Junda Tong ◽  
Jun Ma ◽  
Daming Wang ◽  
Feng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Low Temperature ◽  
Porous Materials ◽  
Porous Electrodes ◽  
Tissue Engineering Scaffolds ◽  
Material Extrusion ◽  
Low Temperature Deposition ◽  
Wide Range ◽  
Temperature Deposition

Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

scholarly journals PLGA/COL I Composite Scaffold Printed by a Low-temperature Deposition Manufacturing Technique for Application to Cartilage Tissue Engineering

2020 ◽  
Author(s):  
Liangquan Peng ◽  
Yong He ◽  
Weimin Zhu ◽  
Wei Lu ◽  
Yong Huang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Low Temperature ◽  
Composite Scaffold ◽  
Cartilage Tissue Engineering ◽  
Three Dimensional ◽  
Cartilage Tissue ◽  
Composite Scaffolds ◽  
Low Temperature Deposition ◽  
Temperature Deposition

Abstract Background Composite scaffolds of poly(lactic-co-glycolic acid) (PLGA) and PLGA/COL I were developed by a low-temperature deposition manufacturing (LDM) technique using three-dimensional printing technology. Their physical properties were tested, and the scaffolds were then used as cell culture platforms to prepare an ideal scaffold for cartilage tissue engineering. Methods The LDM technique was used to fabricate PLGA and PLGA/COL I composite scaffolds. The macrostructure, micromorphology, porosity, hydrophobicity, mechanical properties, and chemical structure of these scaffolds were examined. Primary chondrocytes were isolated and identified, second-passage cells were seeded onto the two scaffolds, and the adhesion and proliferation of the cells were determined. Results Both the PLGA and PLGA/COL I scaffolds prepared by LDM displayed a regular three-dimensional structure with high porosity. The PLGA scaffold had better mechanical properties than the PLGA/COL I scaffold, while the latter had significantly higher hydrophilicity than the former. The PLGA/COL I scaffold cultured with chondrocytes exhibited a higher adhesion rate and proliferation rate than the PLGA/COL I scaffold. Conclusion The novel PLGA/COL I composite scaffold printed by the LDM technique exhibited favourable biocompatibility and biomechanical characteristics and could be a good candidate for cartilage tissue engineering.

The Research of Tissue Engineering Scaffold about Spinal Cord Injury

2010 ◽  
Vol 33 ◽  
pp. 383-389
Author(s):  
Jian Hui Cai ◽  
Ting Chun Shi ◽  
Xian Hu ◽  
Mei Hua Chen
Keyword(s):  
Spinal Cord ◽  
Tissue Engineering ◽  
Spinal Cord Injury ◽  
Low Temperature ◽  
Rapid Development ◽  
High Porosity ◽  
Low Temperature Deposition ◽  
Cord Injury ◽  
Small Pore ◽  
Temperature Deposition

The rapid development of tissue engineering brings new hope to the neurological function recovery after spinal cord injury. The three-dimensional structure of scaffold is a key factor to treat spinal cord injury in tissue engineering method. In this paper, low-temperature deposition manufacturing (LDM) is discussed and basic process about scaffold forming is brief related. The principle of low-temperature deposition manufacturing and some important process parameters were studied. Some experience values are obtained from experiment. The biological environment in vivo was proposed as an important basis for the design of spinal cord scaffold. Then the spinal cord scaffold is separated into gray matter and white matter induced function area by the separate layer of low porosity and small pore size. The experiment results show that the big pores of scaffold are round and regular. The scaffold includes a large number of irregular pore structure, and good penetrating. The scaffold porosity of 86.38% could well meet the needs of the high porosity.

The Research on a New Feeding Device of Low-Temperature Deposition for Fabricating Tissue Engineering Scaffolds

2012 ◽  
Vol 522 ◽  
pp. 92-96 ◽  
Author(s):  
Ying Liu ◽  
Shu Hui Fang ◽  
Zheng Zhong Han ◽  
Da Li Liu ◽  
Yuan Yuan Liu ◽  
...  
Keyword(s):  
Low Temperature ◽  
Feeding System ◽  
Tissue Engineering Scaffolds ◽  
Pressure Relief ◽  
Regulation Scheme ◽  
Low Temperature Deposition ◽  
Time Calculation ◽  
Temperature Deposition ◽  
Valve Control ◽  
Rapid Pressure

Low-temperature deposition manufacturing (LDM) has been proven as an effective bone scaffold preparation process, but its further application has been seriously hindered by the existing material over-accumulation problem. In view of the over-accumulation problem of the traditional pneumatic extrusion material feeding way, designed and developed a feeding system based on pneumatic-extrusion and valve-control, which can achieve rapid pressure/relief, Combined with the inflation / deflation time calculation method of fixed volume container for analysis and calculation. A unified data management method of the material feeding device and a regulation scheme of the controller are given. Experimental results show that, by adjusting parameters, the feeding system based on pneumatic-extrusion and valve-control can achieve rapid gas pressure/relief, the flux has been well controlled, the over-accumulation on deposition path at the end has been eliminated, which lead to effective guarantee of scaffold forming quality.

Fabrication of Chitosan-nanohydroxyapatite Scaffolds via Low-temperature Deposition Manufacturing

2011 ◽  
Vol 26 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Xiong-Fei ZHENG ◽  
Wen-Jie ZHAI ◽  
Ying-Chun LIANG ◽  
Tao SUN
Keyword(s):  
Low Temperature ◽  
Low Temperature Deposition ◽  
Temperature Deposition
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