Properties of an injectable low modulus PMMA bone cement for osteoporotic bone

2008 ◽  
Vol 86B (2) ◽  
pp. 474-482 ◽  
Author(s):  
Andreas Boger ◽  
Marc Bohner ◽  
Paul Heini ◽  
Sophie Verrier ◽  
Erich Schneider
Keyword(s):  
Bone Cement ◽  
Osteoporotic Bone ◽  
Pmma Bone Cement ◽  
Low Modulus

scholarly journals Modification of Mechanical Properties, Polymerization Temperature, and Handling Time of Polymethylmethacrylate Cement for Enhancing Applicability in Vertebroplasty

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ching-Lung Tai ◽  
Po-Liang Lai ◽  
Wei-De Lin ◽  
Tsung-Tin Tsai ◽  
Yen-Chen Lee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Cement ◽  
Castor Oil ◽  
Oil Content ◽  
Handling Time ◽  
Polymerization Temperature ◽  
Preparation Temperature ◽  
Maximum Compression ◽  
Pmma Bone Cement ◽  
Low Modulus

Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material’s excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentioned problems. Modified bone cements were prepared by combining PMMA with three different volume fractions of castor oil (5%, 10%, and 15%). The peak polymerization temperatures, times to achieve the peak polymerization temperature, porosities, densities, modulus and maximum compression strengths of standard (without castor oil), and modified cements were investigated following storage at ambient temperature (22°C) or under precooling conditions (3°C). Six specimens were tested in each group of the aforementioned parameters. Increasing castor oil content and precooling treatment effectively decreased the peak polymerization temperatures and increased the duration to achieve the peak polymerization temperature (P<0.05). Furthermore, the mechanical properties of the material, including density, modulus, and maximum compression strength, decreased with increasing castor oil content. However, preparation temperature (room temperature versus precooling) had no significant effect (P>0.05) on these mechanical properties. In conclusion, the addition of castor oil to PMMA followed by precooling created an ideal modified bone cement with a low modulus, low polymerization temperature, and long handling time, enhancing its applicability and safety for vertebroplasty.

scholarly journals Low-modulus PMMA bone cement modified with castor oil

2011 ◽  
Vol 21 (5-6) ◽  
pp. 323-332 ◽  
Author(s):  
Alejandro López ◽  
Andreas Hoess ◽  
Thomas Thersleff ◽  
Marjam Ott ◽  
Håkan Engqvist ◽  
...  
Keyword(s):  
Bone Cement ◽  
Castor Oil ◽  
Pmma Bone Cement ◽  
Low Modulus

An Automatic Injection Device for Precise Cement Delivery During Osteoporotic Bone Augmentation

2011 ◽  
Author(s):  
Michael D. Kutzer ◽  
Ehsan Basafa ◽  
Yoshito Otake ◽  
Mehran Armand
Keyword(s):  
Bone Cement ◽  
Ease Of Use ◽  
Design Parameters ◽  
Osteoporotic Bone ◽  
Injection Device ◽  
High Injection ◽  
Pmma Bone Cement ◽  
Automatic Placement ◽  
Set Up ◽  
Injection Rates

Augmentation of osteoporotic bone with polymethylmethacrylate (PMMA) bone cement has been shown to be effective in reducing the risk of bone fracture. Injection of the highly viscous bone cement, however, is challenging mainly due to high injection forces required to maintain the nominal injection rates. Also, effective placement of the cement requires precise planning and execution. We are developing a surgical workstation for planning and executing proximal femur augmentation. As a crucial part of the framework, we have designed and fabricated a prototype automatic injection device that provides the substantial forces while maintaining the planned injection rates. Design parameters were determined based on the criteria available in the literature and our preliminary tests. Intended features for the device included high injection force capability, precisely controllable injection and ease of use. A number of calibration experiments were performed to ensure that the device meets the intended criteria. The device can be quickly set up before the surgical operation and can operate in manual or automatic placement configurations. The automatic injection device can also be used for a range of other orthopaedic applications involving direct augmentation of the bones or screws fixated in the bones.

In vivo response to a low-modulus PMMA bone cement in an ovine model

2018 ◽  
Vol 72 ◽  
pp. 362-370 ◽  
Author(s):  
Céline Robo ◽  
Gry Hulsart-Billström ◽  
Malin Nilsson ◽  
Cecilia Persson
Keyword(s):  
Bone Cement ◽  
Ovine Model ◽  
Pmma Bone Cement ◽  
Low Modulus

scholarly journals Influence of HRGO Nanoplatelets on Behaviour and Processing of PMMA Bone Cement for Surgery

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2027
Author(s):  
Jaime Orellana ◽  
Ynés Yohana Pastor ◽  
Fernando Calle ◽  
José Ygnacio Pastor
Keyword(s):  
Graphene Oxide ◽  
Methyl Methacrylate ◽  
Bone Cement ◽  
Reduced Graphene Oxide ◽  
Sintering Temperature ◽  
Structural Function ◽  
Mechanical And Thermal Properties ◽  
Poly Methyl Methacrylate ◽  
Pmma Bone Cement ◽  
Reduced Graphene

Bone cement, frequently based on poly (methyl methacrylate), is commonly used in different arthroplasty surgical procedures and its use is essential for prosthesis fixation. However, its manufacturing process reaches high temperatures (up to 120 °C), producing necrosis in the patients' surrounding tissues. To help avoid this problem, the addition of graphene could delay the polymerisation of the methyl methacrylate as it could, simultaneously, favour the optimisation of the composite material's properties. In this work, we address the effect of different percentages of highly reduced graphene oxide with different wt.% (0.10, 0.50, and 1.00) and surface densities (150, 300, 500, and 750 m2/g) on the physical, mechanical, and thermal properties of commercial poly (methyl methacrylate)-based bone cement and its processing. It was noted that a lower sintering temperature was achieved with this addition, making it less harmful to use in surgery and reducing its adverse effects. In contrast, the variation of the density of the materials did not introduce significant changes, which indicates that the addition of highly reduced graphene oxide would not significantly increase bone porosity. Lastly, the mechanical properties (strength, elastic modulus, and fracture toughness) were reduced by almost 20%. Nevertheless, their typical values are high enough that these new materials could still fulfil their structural function. In conclusion, this paper presents a way to control the sintering temperature, without significant degradation of the mechanical performance, by adding highly reduced graphene oxide so that local necrosis of bone cement based on poly (methyl methacrylate) used in surgery is avoided.

scholarly journals Developing of PMMA Bone Cement Performance by Modified TiO2NPs

2021 ◽  
Vol 1094 (1) ◽  
pp. 012150
Author(s):  
S K Al-Janabi ◽  
M H Al-Maamori ◽  
A J Braihi
Keyword(s):  
Bone Cement ◽  
Pmma Bone Cement

Development of Novel Bioactive PMMA-Based Bone Cement and its In Vitro and In Vivo Evaluation

2006 ◽  
Vol 309-311 ◽  
pp. 801-804 ◽  
Author(s):  
S.B. Cho ◽  
Akari Takeuchi ◽  
Ill Yong Kim ◽  
Sang Bae Kim ◽  
Chikara Ohtsuki ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Compressive Strength ◽  
Bone Cement ◽  
The Novel ◽  
In Vivo Evaluation ◽  
Natural Bone ◽  
Pmma Bone Cement ◽  
Rabbit Tibia

In order to overcome the disadvantage of commercialized PMMA bone cement, we have developed novel PMMA-based bone cement(7P3S) reinforced by 30 wt.% of bioactive CaO-SiO2 gel powders to induce the bioactivity as well as to increase mechanical property for the PMMA bone cement. The novel 7P3S bone cement hardened after mixing for about 7 minutes. For in vitro evaluation, apatite forming ability of it was investigated using SBF. When the novel 7P3S bone cement was soaked into SBF, it formed apatite on its surfaces within 1 week Furthermore; there is no decrease in its compressive strength within 9 weeks soaking in SBF. It is though that hardly decrease in compressive strength of 7P3S bone cement in SBF is due to the relative small amount of gel powder or its spherical shape and monosize. In vivo evaluation of the novel 7P3S bone cement was carried out using rabbit. After implantion into rabbit tibia for several periods, the interface between novel bone cement and natural bone was evaluated by CT images. According to the results, the novel bone cement directly contact to the natural bone without fibrous tissue after implantation for 4 weeks. This results indicates that the newly developed 7P3S bone cement can bond to the living bone and also be effectively used as bioactive bone cement without decrease in mechanical property.

The effect on the fatigue strength of bone cement of adding sodium fluoride

2001 ◽  
Vol 215 (2) ◽  
pp. 251-253 ◽  
Author(s):  
C Minari ◽  
M Baleanil ◽  
L Cristofolini ◽  
F Baruffaldi
Keyword(s):  
Fatigue Strength ◽  
Bone Cement ◽  
Sodium Fluoride ◽  
Biomedical Applications ◽  
Cement Mantle ◽  
Fatigue Tests ◽  
Fatigue Performance ◽  
Bone Cements ◽  
The Novel ◽  
Pmma Bone Cement

New bone cements that include several additives are currently being investigated and tested. One such additive is sodium fluoride (NaF), which promotes bone formation, facilitating implant integration and success. The influence of NaF on the fatigue performance of the cement as used in biomedical applications was tested in this paper. In fact fatigue failure of the cement mantle is a major factor limiting the longevity of a cemented implant. An experimental bone cement with added NaF (12wt%) was investigated. The fatigue strength of the novel bone cement was evaluated in comparison with the cement without additives; fatigue tests were conducted according to current standards. The load levels were arranged based on a validated, statistically based optimization algorithm. The curve of stress against number of load cycles and the endurance limit were obtained and compared for both formulations. The results showed that the addition of NaF (12 wt %) to polymethylmethacrylate (PMMA) bone cement does not affect the fatigue resistance of the material. Sodium fluoride can safely be added to the bone cement without altering the fatigue performance of the PMMA bone cement.

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