In vitro andin vivo biocompatibility evaluation of a polyalkylimide hydrogel for soft tissue augmentation

2005 ◽  
Vol 72B (2) ◽  
pp. 230-238 ◽  
Author(s):  
P.A. Ramires ◽  
M.A. Miccoli ◽  
E. Panzarini ◽  
L. Dini ◽  
C. Protopapa
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Augmentation ◽  
Tissue Augmentation

In vitro and in vivo comparison of five biomaterials used for orthopedic soft tissue augmentation

2008 ◽  
Vol 69 (1) ◽  
pp. 148-156 ◽  
Author(s):  
James L. Cook ◽  
Derek B. Fox ◽  
Keiichi Kuroki ◽  
Manuel Jayo ◽  
Patrick G. De Deyne
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Augmentation ◽  
Tissue Augmentation

scholarly journals In Vitro Biodegradation Pattern of Collagen Matrices for Soft Tissue Augmentation

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2633
Author(s):  
Cristina Vallecillo ◽  
Manuel Toledano-Osorio ◽  
Marta Vallecillo-Rivas ◽  
Manuel Toledano ◽  
Raquel Osorio
Keyword(s):  
Soft Tissue ◽  
Hydrolytic Degradation ◽  
Phosphate Buffer Solution ◽  
Soft Tissue Augmentation ◽  
Buffer Solution ◽  
Collagen Matrices ◽  
Bacterial Collagenase ◽  
Tissue Augmentation ◽  
Tissue Grafts

Collagen matrices have become a great alternative to the use of connective tissue grafts for soft tissue augmentation procedures. One of the main problems with these matrices is their volume instability and rapid degradation. This study has been designed with the objective of examining the degradation of three matrices over time. For this purpose, pieces of 10 × 10 mm2 of Fibro-Gide, Mucograft and Mucoderm were submitted to three different degradation tests—(1) hydrolytic degradation in phosphate buffer solution (PBS); (2) enzyme resistance, using a 0.25% porcine trypsin solution; and (3) bacterial collagenase resistance (Clostridium histolyticum)—over different immersion periods of up to 50 days. Weight measurements were performed with an analytic microbalance. Thickness was measured with a digital caliper. A stereomicroscope was used to obtain the matrices’ images. ANOVA and Student–Newman–Keuls tests were used for mean comparisons (p < 0.05), except when analyzing differences between time-points within the same matrix and solution, where pair-wise comparisons were applied (p < 0.001). Fibro-Gide attained the highest resistance to all degradation challenges. The bacterial collagenase solution was shown to constitute the most aggressive test as all matrices presented 100% degradation before 14 days of storage.

Soft Tissue Augmentation Using In Vitro Differentiated Adipocytes

2011 ◽  
Vol 37 (6) ◽  
pp. 760-767
Author(s):  
SEONG-HO JEONG ◽  
SEUNG-KYU HAN ◽  
WOO-KYUNG KIM
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Augmentation ◽  
Tissue Augmentation

scholarly journals Soft Tissue Augmentation Using Silk Gels: An In Vitro and In Vivo Study

2009 ◽  
Vol 80 (11) ◽  
pp. 1852-1858 ◽  
Author(s):  
Olivier Etienne ◽  
Aurore Schneider ◽  
Jonathan A. Kluge ◽  
Claire Bellemin-Laponnaz ◽  
Camille Polidori ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Augmentation ◽  
In Vivo Study ◽  
Tissue Augmentation

Study of a novel injectable hydrogel of human-like collagen and carboxymethylcellulose for soft tissue augmentation

e-Polymers ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Bowen Liu ◽  
Xiaoxuan Ma ◽  
Chenhui Zhu ◽  
Yu Mi ◽  
Daidi Fan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Biomedical Applications ◽  
Soft Tissue Augmentation ◽  
Injectable Hydrogel ◽  
Amide Bonds ◽  
Tissue Augmentation ◽  
Biocompatibility Test ◽  
Good Biocompatibility ◽  
Equilibrium Swelling Ratio

Abstract A novel injectable hydrogel was fabricated by human-like collagen (HLC) and carboxymethylcellulose (CMC) with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and adipic acid dihydrazide (ADH) as cross-linkers. The morphology and structure of the hydrogels were characterized by scanning electron microscope and Fourier transform infrared spectroscopy. The results showed that the HLC and CMC were successfully cross-linked through amide bonds and HLC could enhance the pore size of the composite, whereas CMC could be a strong backbone in the hydrogel to keep its appearance. The results of thermogravimetric analysis showed that the thermostability of HLC/CMC was strengthened significantly as compared with that of CMC. The tests of the equilibrium swelling ratio and in vitro degradability indicated that the HLC/CMC hydrogel possesses good water absorbing ability and slow degradability in vitro. Finally, biocompatibility test provided the possibility that HLC/CMC hydrogels are suitable for biomedical applications such as soft tissue augmentation for their good biocompatibility.

An autologous protein gel for soft tissue augmentation: in vitro characterization and clinical evaluation

2018 ◽  
Vol 18 (3) ◽  
pp. 762-772 ◽  
Author(s):  
Elena Fedyakova ◽  
Ander Pino ◽  
Lidiya Kogan ◽  
Charusa Eganova ◽  
María Troya ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Clinical Evaluation ◽  
Soft Tissue Augmentation ◽  
Protein Gel ◽  
Tissue Augmentation ◽  
In Vitro Characterization

scholarly journals State of the Art on Biomaterials for Soft Tissue Augmentation in the Oral Cavity. Part II: Synthetic Polymers-Based Biomaterials

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1845
Author(s):  
Manuel Toledano ◽  
Manuel Toledano-Osorio ◽  
Álvaro Carrasco-Carmona ◽  
Cristina Vallecillo ◽  
Raquel Toledano ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Oral Cavity ◽  
Biodegradable Polymers ◽  
Computer Aided Design ◽  
Synthetic Polymers ◽  
Soft Tissue Augmentation ◽  
Tissue Augmentation ◽  
Computer Aided

Most of the polymers used as biomaterials for scaffolds are naturally occurring, synthetic biodegradable, and synthetic non-biodegradable polymers. Since synthetic polymers can be adapted for obtaining singular desired characteristics by applying various fabrication techniques, their use has increased in the biomedical field, in dentistry in particular. The manufacturing methods of these new structures include many processes, such as electrospinning, 3D printing, or the use of computer-aided design/computer-aided manufacturing (CAD/CAM). Synthetic polymers show several drawbacks that can limit their use in clinical applications, such as the lack of cellular recognition, biodegradability, and biocompatibility. Moreover, concerning biodegradable polymers, the time for matrix resorption is not predictable, and non-resorbable matrices are preferred for soft tissue augmentation in the oral cavity. This review aimed to determine a new biomaterial to offset the present shortcomings in the oral environment. Researchers have recently proposed a novel non-resorbable composite membrane manufactured via electrospinning that has allowed obtaining remarkable in vivo outcomes concerning angiogenesis and immunomodulation throughout the polarization of macrophages. A prototype of the protocol for in vitro and in vivo experimentation with hydrogels is explained in order to encourage innovation into the development of promising biomaterials for soft tissue augmentation in the near future.

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