Nanophase surface arrays on poly (lactic‐co‐glycolic acid) upregulate neural cell functions

2021 ◽  
Author(s):  
Didem Mimiroglu ◽  
Tulin Yanik ◽  
Batur Ercan
Keyword(s):  
Glycolic Acid ◽  
Neural Cell ◽  
Cell Functions

Influence of micro and submicro poly(lactic-glycolic acid) fibers on sensory neural cell locomotion and neurite growth

2013 ◽  
Vol 101 (7) ◽  
pp. 1200-1208 ◽  
Author(s):  
Carmen Binder ◽  
Vincent Milleret ◽  
Heike Hall ◽  
Daniel Eberli ◽  
Tessa Lühmann
Keyword(s):  
Glycolic Acid ◽  
Neurite Growth ◽  
Neural Cell ◽  
Cell Locomotion ◽  
Sensory Neural

Live Imaging of Neural Cell Functions

2009 ◽  
pp. 353-373
Author(s):  
Sabine Bavamian ◽  
Eliana Scemes ◽  
Paolo Meda
Keyword(s):  
Live Imaging ◽  
Neural Cell ◽  
Cell Functions

Improved Cardiomyocyte Functions of Carbon Nanofiber Cardiac Patches

2012 ◽  
Vol 1417 ◽  
Author(s):  
David A. Stout ◽  
Emilia Raimondo ◽  
Thomas J. Webster
Keyword(s):  
Electrical Stimulation ◽  
Glycolic Acid ◽  
Troponin I ◽  
Carbon Nanofiber ◽  
Myocardial Tissue ◽  
Human Cardiomyocytes ◽  
Cell Functions ◽  
Stimulation System ◽  
Myocardial Tissue Engineering

ABSTRACTThe objective of the present in vitro research was to determine cardiomyocyte functions on poly-lactic-co-glycolic acid (50:50 (PLA:PGA); PLGA) with greater amounts of carbon nanofibers (CNFs) using an in vitro electrical stimulation system for myocardial tissue engineering applications. The addition of CNFs can increase the conductivity and strength of pure PLGA. For this reason, different PLGA: CNF ratios (100:0, 75:25, 50:50, 25:75, 0:100 wt%) were created where conductivity and cytocompatibility properties under electrical stimulation with human cardiomyocytes were determined. Results showed that PLGA:CNF materials were conductive and that conductivity increased with greater amounts of PLGA added, from 0 S.m-1 for 100:0 wt% (pure PLGA) to 6.5x10-3 S.m-1 for 0:100 wt% (pure CNFs) materials. Furthermore, results indicated that cardiomyocyte cell density increased with continuous electrical stimulation (rectangular, 2 nm, 5 V/cm, 1 Hz) after 1, 3, and 5 days as well as a slight increase in Troponin I excretion compared to non-electrically stimulated normal cardiomyocyte cell functions. This study, thus, provides an alternative conductive scaffold using nanotechnology which should be further explored for numerous cardiovascular applications.

Effects of PLGA Nano Patterns on the Responses of Healthy Osteoblasts

2012 ◽  
Vol 1412 ◽  
Author(s):  
Yongchen Wang ◽  
Lijuan Zhang ◽  
Linlin Sun ◽  
Thomas J. Webster
Keyword(s):  
Glycolic Acid ◽  
Bone Cells ◽  
Bone Cancer ◽  
Bone Cell ◽  
The Self ◽  
Healthy Human ◽  
Surface Features ◽  
Flat Surfaces ◽  
Cell Functions ◽  
Osteoblast Adhesion

ABSTRACTPoly(lactic-co-glycolic acid) (PLGA) films with flat surfaces and with 27nm, 190nm, 300nm, 400nm, and 520nm surface features were synthesized using a template method with polydimethylsiloxane (PDMS) molds. The nano patterns were transferred from the self-assembled polystyrene beads to the PLGA films through PDMS molds. After synthesis, the nano patterns were confirmed by AFM height scans. In order to investigate the influence of the materials on bone cells, healthy human osteoblasts were cultured on the PLGA films. The 27nm PLGA surface showed the maximum osteoblast adhesion density and a significant increase compared with the other surface features. For these reasons, and since previous studies have highlighted that similar nanometer surface features on PLGA decreased functions of other cancer cells, this study suggests that PLGA with 27nm surface features should be further studied for bone cancer applications where healthy bone cell functions need to be promoted and cancerous bone cell functions inhibited.

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