Evaluation of the effect of 3D porous Chitosan‐alginate scaffold stiffness on breast cancer proliferation and migration

2021 ◽  
Author(s):  
Minh‐Chau N. Le ◽  
Kailei Xu ◽  
Zi Wang ◽  
Sean Beverung ◽  
Robert L. Steward ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Proliferation ◽  
Porous Chitosan ◽  
And Migration ◽  
Alginate Scaffold ◽  
Proliferation And Migration

scholarly journals Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival

2018 ◽  
Author(s):  
Nishanth Ulhas Nair ◽  
Avinash Das ◽  
Vasiliki-Maria Rogkoti ◽  
Michiel Fokkelman ◽  
Richard Marcotte ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Patient Survival ◽  
Breast Cancer Cell Lines ◽  
Cancer Treatments ◽  
Cancer Proliferation ◽  
Knock Down ◽  
And Migration ◽  
Proliferation And Migration

AbstractThe efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally measured proliferation and migration phenotypes across more than 40 breast cancer cell-lines. Based on the latter, we built and validated individual predictors of breast cancer proliferation and migration levels from the cells’ transcriptomics. We then apply these predictors to estimate the proliferation and migration levels of more than 1000 TCGA breast cancer tumors. Reassuringly, both estimates increase with tumor’s aggressiveness, as qualified by its stage, grade, and subtype. However, predicted tumor migration levels are significantly more strongly associated with patient survival than the proliferation levels. We confirm these finding by conducting siRNA knock-down experiments on the highly migratory MDA-MB-231 cell lines and deriving gene knock-down based proliferation and migration signatures. We show that cytoskeletal drugs might be more beneficial in patients with high predicted migration levels. Taken together, these results testify to the importance of migration levels in determining patient survival.

scholarly journals MiR-27a-3p Targeting GSK3β Promotes Triple-Negative Breast Cancer Proliferation and Migration Through Wnt/β-Catenin Pathway

2020 ◽  
Vol Volume 12 ◽  
pp. 6241-6249
Author(s):  
Ruizhen Wu ◽  
Bingqing Zhao ◽  
Xunxin Ren ◽  
Shiheng Wu ◽  
Mingzao Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis

EBioMedicine ◽  
2019 ◽  
Vol 41 ◽  
pp. 384-394 ◽  
Author(s):  
Lianpin Wu ◽  
Donghong Zhang ◽  
Li Zhou ◽  
Yuqing Pei ◽  
Yixuan Zhuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Proliferation ◽  
And Migration ◽  
Proliferation And Migration

Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors

2010 ◽  
Vol 18 (22) ◽  
pp. 8066-8075 ◽  
Author(s):  
Fathy A. Behery ◽  
Ahmed Y. Elnagar ◽  
Mohamed R. Akl ◽  
Vikram B. Wali ◽  
Bilal Abuasal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Proliferation ◽  
And Migration ◽  
Proliferation And Migration
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