scholarly journals MiR-27a-3p Targeting GSK3β Promotes Triple-Negative Breast Cancer Proliferation and Migration Through Wnt/β-Catenin Pathway

2020 ◽  
Vol Volume 12 ◽  
pp. 6241-6249
Author(s):  
Ruizhen Wu ◽  
Bingqing Zhao ◽  
Xunxin Ren ◽  
Shiheng Wu ◽  
Mingzao Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cancer Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167445 ◽  
Author(s):  
Miriam Fernandez-Gallardo ◽  
Ricardo González-Ramírez ◽  
Alejandro Sandoval ◽  
Ricardo Felix ◽  
Eduardo Monjaraz
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jintao Qian ◽  
Xinhan Lei ◽  
Yue Sun ◽  
Lu Zheng ◽  
Jia Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Luciferase Reporter ◽  
Western Blot Assay ◽  
Cell Proliferation And Migration ◽  
Tnbc Cell ◽  
And Migration ◽  
Proliferation And Migration

Abstract Background Growing evidence has demonstrated that long non-coding RNAs (lncRNAs) can function as modulators in the development of triple-negative breast cancer (TNBC). However, the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in TNBC remains unclear. Therefore, our study aimed at investigating the role of SNHG8 in the proliferation and migration of TNBC cells. Methods SNHG8 expression was evaluated using RT-qPCR assay. Cell proliferation and migration were assessed by EdU, colony formation and Transwell assays. The levels of proteins related to EMT process were examined by western blot assay. The interaction among SNHG8, miR-335-5p and pygopus family PHD finger 2 (PYGO2) was detected by RIP assay, RNA pull down assay and luciferase reporter assay. Results SNHG8 expression was significantly up-regulated in TNBC cells. SNHG8 silencing obviously inhibited TNBC cell proliferation, migration and EMT process. Moreover, SNHG8 acted as a sponge to sequester miR-335-5p in TNBC cells. Besides, PYGO2 was proven as a target gene of miR-335-5p, and SNHG8 promoted TNBC cell proliferation, migration and EMT process through regulating miR-335-5p and PYGO2. Conclusions Totally, our study indicated that SNHG8 promoted TNBC cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis.

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