Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co‐loaded nanocarriers on breast cancer cells

2021 ◽  
Author(s):  
Alicja Zajdel ◽  
Adam Wilczok ◽  
Katarzyna Jelonek ◽  
Anna Kaps ◽  
Monika Musiał‐Kulik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Epothilone B

scholarly journals IR-780 based-nanoparticle cytotoxic effect on murine breast cancer cells (Ehrlich)

Mastology ◽  
2018 ◽  
Vol 28 (s1) ◽  
pp. 34-34
Author(s):  
André Luiz Silva Oliveira ◽  
◽  
Nicholas Zufelato ◽  
Letícia Reis Silva ◽  
Andris Figueiroa Bakuzis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect

scholarly journals Cytotoxic effect of Drimia maritima bulb extract and induction of mitochondrial apoptotic signaling in human breast cancer cells, MCF-7 and MDA-MB-468

2018 ◽  
Vol Volume 11 ◽  
pp. 7669-7677 ◽  
Author(s):  
Maryam Hamzeloo-Moghadam ◽  
Mahmoud Aghaei ◽  
Mohammad Hossein Abdolmohammadi ◽  
Amir Khalaj ◽  
Faranak Fallahian
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Apoptotic Signaling ◽  
Mcf 7

Cytotoxic effect of thermosensitive magnetoliposomes loaded with gemcitabine and paclitaxel on human primary breast cancer cells (MGSO-3 line)

2020 ◽  
Vol 22 (7) ◽  
Author(s):  
Rita F. L. Ribeiro ◽  
Roberta V. Ferreira ◽  
Davyston C. Pedersoli ◽  
Paulo R. P. Paiva ◽  
Pricila da S. Cunha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Primary Breast Cancer ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect

Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase

Steroids ◽  
2020 ◽  
Vol 160 ◽  
pp. 108656 ◽  
Author(s):  
Ahmed Ismail ◽  
Ahmed S. Doghish ◽  
Bakheet E. M. Elsadek ◽  
Salama A. Salama ◽  
Amr D. Mariee
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Atp Citrate Lyase ◽  
Hydroxycitric Acid ◽  
Citrate Lyase ◽  
Mcf 7

scholarly journals COMBINATION OF HEDYOTIS CORYMBOSA L. AND TINOSPORA CRISPA ETHANOLIC EXTRACT INCREASE CISPLATIN CYTOTOXICITY ON T47D BREAST CANCER CELLS

2018 ◽  
Vol 11 (7) ◽  
pp. 171 ◽  
Author(s):  
Rollando Rollando
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Ethanolic Extract ◽  
T47d Cell ◽  
Apoptosis Induction ◽  
Cell Accumulation ◽  
Cell Cycle Modulation

Objective: Ursolic acid was a compound found in Hedyotis corymbosa L., (HCoL) while berberine found in Tinospora crispa (TCa) which are proven to have cytotoxic effect to cancer cells. This research aims to review the effect of cisplatin, ethanolic extract of HCoL and TCa to the sensitivity increase on breast cancer cells, which will be confirmed through apoptosis induction and cell cycle modulation.Methods: The cytotoxic effect was tested using 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide assay on T47D cell using the IC50 parameter. The combination was tested by determining their combination index (CI) and cell viability. The combination effect of apoptosis induction and cell cycle modulation was observed using flow cytometry method.Results: The cytotoxic test result of the combination shows CI value of below 1 at the concentration of HCoL ethanolic extract as much as 1 μg/mL, TCa ethanolic extract as much as 6 μg/mL, and cisplatin as much as 2,5 μM. The combination of HCoL ethanolic extract, TCa ethanolic extract, and cisplatin results in phase S cell accumulation (29.98%) on breast cancer cell T47D and was able to induce apoptosis.Conclusion: The result proves that ethanolic extract of HCoL and TCa can be developed as a cochemotherapeutic agent with cisplatin to increase the effectivity of breast cancer treatment.

In vitro cytotoxic effect of Trastuzumab in combination with Pertuzumab in breast cancer cells is improved by interleukin-2 activated NK cells

2019 ◽  
Vol 46 (6) ◽  
pp. 6205-6213 ◽  
Author(s):  
Amir Asgari ◽  
Sedigheh Sharifzadeh ◽  
Abbas Ghaderi ◽  
Ahmad Hosseini ◽  
Amin Ramezani
Keyword(s):  
Breast Cancer ◽  
Nk Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Interleukin 2

The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells

2009 ◽  
Vol 20 (8) ◽  
pp. 723-735 ◽  
Author(s):  
Christina W. Yde ◽  
Mathias P. Clausen ◽  
Martin V. Bennetzen ◽  
Anne E. Lykkesfeldt ◽  
Ole G. Mouritsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Antipsychotic Drug ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Tamoxifen Resistant

scholarly journals Conjugation of palbociclib with MHI-148 has an increased cytotoxic effect for breast cancer cells and an altered mechanism of action

2021 ◽  
Author(s):  
Euphemia Leung ◽  
Petr Tomek ◽  
Moana Tercel ◽  
Johannes Reynisson ◽  
Thomas In Hyeup Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Endocrine Therapy ◽  
Mechanism Of Action ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Near Infrared ◽  
Triple Negative ◽  
Mammalian Cell Lines

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with oestrogen receptor positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in the highly aggressive triple-negative breast cancer that lacks sensitivity to chemotherapy or endocrine therapy. We hypothesized that conjugation of the near-infrared dye MHI-148 with palbociclib can produce a potential theranostic in triple-negative as well as oestrogen receptor positive breast cancer cells. In our study, the conjugate was found to have enhanced activity in all mammalian cell lines tested in vitro. However, the conjugate was cytotoxic and did not induce G1 cell cycle arrest in breast cancer cells suggesting the mechanism of action differed from the parent compound palbociclib. The study highlights the importance of investigating the mechanism of conjugates of near-infrared dyes to therapeutic compounds as conjugation can potentially result in a change of mechanism or target, with an enhanced cytotoxic effect in this case.

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