scholarly journals Regional gene therapy with 3D printed scaffolds to heal critical sized bone defects in a rat model

2019 ◽  
Vol 107 (10) ◽  
pp. 2174-2182 ◽  
Author(s):  
Ram Alluri ◽  
Xuan Song ◽  
Sofia Bougioukli ◽  
William Pannell ◽  
Venus Vakhshori ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Rat Model ◽  
Bone Defects ◽  
3D Printed ◽  
Regional Gene

scholarly journals 3D printed hyperelastic “bone” scaffolds and regional gene therapy: A novel approach to bone healing

2018 ◽  
Vol 106 (4) ◽  
pp. 1104-1110 ◽  
Author(s):  
Ram Alluri ◽  
Adam Jakus ◽  
Sofia Bougioukli ◽  
William Pannell ◽  
Osamu Sugiyama ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Healing ◽  
Bone Scaffolds ◽  
Novel Approach ◽  
3D Printed ◽  
Regional Gene

Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model

2021 ◽  
Author(s):  
H Paco Kang ◽  
Hansel Ihn ◽  
Djani M Robertson ◽  
Xiao Chen ◽  
Osamu Sugiyama ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Healing ◽  
Defect Model ◽  
Femoral Defect ◽  
3D Printed ◽  
Regional Gene

Scaffold 3D‐Printed from Metallic Nanoparticles‐Containing Ink Simultaneously Eradicates Tumor and Repairs Tumor‐Associated Bone Defects

Small Methods ◽  
2021 ◽  
pp. 2100536
Author(s):  
Huimin Lin ◽  
Shanwei Shi ◽  
Xinyue Lan ◽  
Xiaolong Quan ◽  
Qinqin Xu ◽  
...  
Keyword(s):  
Metallic Nanoparticles ◽  
Bone Defects ◽  
3D Printed

3D-printed Poly-Lactic Co-Glycolic Acid (PLGA) scaffolds in non-critical bone defects impede bone regeneration in rabbit tibia bone

2021 ◽  
pp. 1-7
Author(s):  
Jin Xi Lim ◽  
Min He ◽  
Alphonsus Khin Sze Chong
Keyword(s):  
Computed Tomography ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Volume Ratio ◽  
Bone Defects ◽  
Control Group ◽  
Micro Computed Tomography ◽  
Rabbit Tibia ◽  
3D Printed ◽  
Critical Bone Defects

BACKGROUND: An increasing number of bone graft materials are commercially available and vary in their composition, mechanism of action, costs, and indications. OBJECTIVE: A commercially available PLGA scaffold produced using 3D printing technology has been used to promote the preservation of the alveolar socket after tooth extraction. We examined its influence on bone regeneration in long bones of New Zealand White rabbits. METHODS: 5.0-mm-diameter circular defects were created on the tibia bones of eight rabbits. Two groups were studied: (1) control group, in which the bone defects were left empty; (2) scaffold group, in which the PLGA scaffolds were implanted into the bone defect. Radiography was performed every two weeks postoperatively. After sacrifice, bone specimens were isolated and examined by micro-computed tomography and histology. RESULTS: Scaffolds were not degraded by eight weeks after surgery. Micro-computed tomography and histology showed that in the region of bone defects that was occupied by scaffolds, bone regeneration was compromised and the total bone volume/total volume ratio (BV/TV) was significantly lower. CONCLUSION: The implantation of this scaffold impedes bone regeneration in a non-critical bone defect. Implantation of bone scaffolds, if unnecessary, lead to a slower rate of fracture healing.

Adenoviral Vector-Mediated NGF Gene Therapy for a Rat Model of Diabetic Bladder Dysfunction

2021 ◽  
Author(s):  
Jian Wang ◽  
Min Guo ◽  
Hongxin Wang ◽  
Jinpeng Hu ◽  
Hao Fu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Rat Model ◽  
Adenoviral Vector ◽  
Bladder Dysfunction ◽  
Diabetic Bladder ◽  
Ngf Gene

Neuroregenerative Gene Therapy to Treat Temporal Lobe Epilepsy in a Rat Model

2021 ◽  
pp. 102198
Author(s):  
Jiajun Zheng ◽  
Tingjie Li ◽  
Shuang Qi ◽  
Bing Qin ◽  
Jiandong Yu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model

scholarly journals In vivo Recombinant Adenovirus-mediated p53 Gene Therapy in a Syngeneic Rat Model for Colorectal Cancer

2004 ◽  
Vol 19 (6) ◽  
pp. 834 ◽  
Author(s):  
Jeong-Heum Baek ◽  
Munna L Agarwal ◽  
Raymond R Tubbs ◽  
Alex Vladisavljevic ◽  
Hiroshi Tomita ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Therapy ◽  
Rat Model ◽  
Recombinant Adenovirus ◽  
P53 Gene

Effect of p53 Gene Therapy Combined with CTLA4Ig Selective Immunosuppression on Prolonged Neointima Formation Reduction in a Rat Model

2000 ◽  
Vol 14 (4) ◽  
pp. 385-392 ◽  
Author(s):  
Enrico Ascher ◽  
Marcel Scheinman ◽  
Anil Hingorani ◽  
Prem Seth ◽  
Venkata K. Marella ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Rat Model ◽  
P53 Gene ◽  
Neointima Formation
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