scholarly journals 3D printed hyperelastic “bone” scaffolds and regional gene therapy: A novel approach to bone healing

2018 ◽  
Vol 106 (4) ◽  
pp. 1104-1110 ◽  
Author(s):  
Ram Alluri ◽  
Adam Jakus ◽  
Sofia Bougioukli ◽  
William Pannell ◽  
Osamu Sugiyama ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Healing ◽  
Bone Scaffolds ◽  
Novel Approach ◽  
3D Printed ◽  
Regional Gene

Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model

2021 ◽  
Author(s):  
H Paco Kang ◽  
Hansel Ihn ◽  
Djani M Robertson ◽  
Xiao Chen ◽  
Osamu Sugiyama ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Healing ◽  
Defect Model ◽  
Femoral Defect ◽  
3D Printed ◽  
Regional Gene

scholarly journals Regional gene therapy with 3D printed scaffolds to heal critical sized bone defects in a rat model

2019 ◽  
Vol 107 (10) ◽  
pp. 2174-2182 ◽  
Author(s):  
Ram Alluri ◽  
Xuan Song ◽  
Sofia Bougioukli ◽  
William Pannell ◽  
Venus Vakhshori ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Rat Model ◽  
Bone Defects ◽  
3D Printed ◽  
Regional Gene

A NOVEL APPROACH TO TURBULENT MULTIPHASE FLOW IMAGING: FLOW IN 3D PRINTED KARSTIC CONDUITS

2016 ◽  
Author(s):  
Samuel N. Jacobson ◽  
◽  
Ellen K. Herman ◽  
Dorothy J. Vesper ◽  
Johnathan E. Moore ◽  
...  
Keyword(s):  
Multiphase Flow ◽  
Flow Imaging ◽  
Novel Approach ◽  
3D Printed

scholarly journals A Novel Approach for a Faster Prototyping of Winter Sport Equipment Using Digital Image Correlation and 3D Printing

Proceedings ◽  
2020 ◽  
Vol 49 (1) ◽  
pp. 125
Author(s):  
Martino Colonna ◽  
Benno Zingerle ◽  
Maria Federica Parisi ◽  
Claudio Gioia ◽  
Alessandro Speranzoni ◽  
...  
Keyword(s):  
3D Printing ◽  
Digital Image Correlation ◽  
Digital Image ◽  
Sport Activity ◽  
Image Correlation ◽  
Topological Optimization ◽  
Design Parameters ◽  
Sport Equipment ◽  
Novel Approach ◽  
3D Printed

The optimization of sport equipment parts requires considerable time and high costs due to the high complexity of the development process. For this reason, we have developed a novel approach to decrease the cost and time for the optimization of the design, which consists of producing a first prototype by 3D printing, applying the forces that normally acts during the sport activity using a test bench, and then measuring the local deformations using 3D digital image correlation (DIC). The design parameters are then modified by topological optimization and then DIC is performed again on the new 3D-printed modified part. The DIC analysis of 3D-printed parts has shown a good agreement with that of the injection-molded ones. The deformation measured with DIC are also well correlated with those provided by finite element method (FEM) analysis, and therefore DIC analysis proves to be a powerful tool to validate FEM models.

scholarly journals EFFECT OF EXTRUSION PROCESS PARAMETERS ON MECHANICAL PROPERTIES OF 3D PRINTED PLA PRODUCT

2021 ◽  
Vol 6 (2) ◽  
pp. 119
Author(s):  
Nanang Ali Sutisna ◽  
Rakha Amrillah Fattah
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
Fused Deposition Modeling ◽  
Extrusion Process ◽  
Experimental Procedure ◽  
Fused Deposition ◽  
Novel Approach ◽  
Deposition Modeling ◽  
3D Printed ◽  
3D Digital Models

The method of producing items through synchronously depositing material level by level, based on 3D digital models, is named Additive Manufacturing (AM) or 3D-printing. Amongs many AM methods, the Fused Deposition Modeling (FDM) technique along with PLA (Polylactic acid) material is commonly used in additive manufacturing. Until now, the mechanical properties of the AM components could not be calculated or estimated until they've been assembled and checked. In this work, a novel approach is suggested as to how the extrusion process affects the mechanical properties of the printed component to obtain how the parts can be manufactured or printed to achieve improved mechanical properties. This methodology is based on an experimental procedure in which the combination of parameters to achieve an optimal from a manufacturing experiment and its value can be determined, the results obtained show the effect of the extrusion process affects the mechanical properties.

scholarly journals “Same Day” Ex-vivo Regional Gene Therapy: A Novel Strategy to Enhance Bone Repair

2011 ◽  
Vol 19 (5) ◽  
pp. 960-968 ◽  
Author(s):  
Mandeep S Virk ◽  
Osamu Sugiyama ◽  
Sang H Park ◽  
Sanjiv S Gambhir ◽  
Douglas J Adams ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bone Repair ◽  
Ex Vivo ◽  
Novel Strategy ◽  
Regional Gene

scholarly journals Histopathological evaluation of polycaprolactone nanocomposite compared with tricalcium phosphate in bone healing

2018 ◽  
Vol 62 (3) ◽  
pp. 385-394 ◽  
Author(s):  
Hadi Eftekhari ◽  
Alireza Jahandideh ◽  
Ahmad Asghari ◽  
Abolfazl Akbarzadeh ◽  
Saeed Hesaraki
Keyword(s):  
Bone Tissue ◽  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Healing Process ◽  
Control Group ◽  
Time Intervals ◽  
Positive Effects ◽  
Bone Scaffolds ◽  
Modern Engineering ◽  
And Control

AbstractIntroductionIn recent years, the use of bone scaffolds as bone tissue substitutes, especially the use of such as hydroxyapatite and tricalcium phosphate, has been very popular. Today, the use of modern engineering techniques and advances in nanotechnology have expanded the use of nanomaterials as bone scaffolds for bone tissue applications.Material and MethodsThis study was performed on 60 adult male New Zealand rabbits divided into four experimental groups: the control group without any treatment, the second group receiving hydroxyapatite, the third group treated with β-tricalcium phosphate, and the fourth group receiving nanocomposite polycaprolactone (PCL) scaffold. In a surgical procedure, a defect 6 mm in diameter was made in a hind limb femur. Four indexes were used to assess histopathology, which were union index, spongiosa index, cortex index, and bone marrow.ResultsThe results showed that nanocomposite PCL and control groups always had the respective highest and lowest values among all the groups at all time intervals. The histopathological assessment demonstrated that the quantity of newly formed lamellar bone in the nanocomposite PCL group was higher than in other groups.ConclusionAll these data suggest that PCL had positive effects on the bone healing process, which could have great potential in tissue engineering and clinical applications.

Editing CCR5: A Novel Approach to HIV Gene Therapy

2015 ◽  
pp. 117-130 ◽  
Author(s):  
Tatjana I. Cornu ◽  
Claudio Mussolino ◽  
Kristie Bloom ◽  
Toni Cathomen
Keyword(s):  
Gene Therapy ◽  
Novel Approach

scholarly journals Correction to: Biomechanical properties of 3D-printed bone scaffolds are improved by treatment with CRFP

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Carlos G. Helguero ◽  
Vamiq M. Mustahsan ◽  
Sunjit Parmar ◽  
Sahana Pentyala ◽  
John L. Pfail ◽  
...  
Keyword(s):  
Biomechanical Properties ◽  
Bone Scaffolds ◽  
3D Printed
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